LONGEVITY with Nathalie Niddam

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If you've been hearing everyone talk about exosomes but still aren't exactly sure what they are—or whether they're actually worth the hype—this episode is for you. Today I'm joined once again by Amitay Eshel and Anastasia Khodzhaeva from Young Goose to separate the science from the marketing and unpack what exosomes are really doing inside your skin.
We explore why your skin may be the most honest reflection of your biological age, how mitochondrial health and cellular repair influence the way you age, and why not all exosome products are created equal. We also get into the future of longevity skincare, formulation science, and what consumers should actually be looking for before spending money on the latest trend.
Special Young Goose Offer: Click HERE and use code NAT10 to save on Young Goose products!
Links to previous episode:
#381: Better Than Lasers: NAD+, Spermidine, and Methylene Blue for Youthful Skin | Amitay Eshel and Anastasia Khodzhaeva
#209: How to Reverse The Aging Process Without Long Term Damage with Amitay Eshel
#118: Our Skin is a Mirror: Why Skin Health is a Marker of Overall Health
#71: How to Boost the Effects of Anti-Aging Skincare and Light Therapy
Episode Timestamps:
Introduction & Returning Guests ... 00:00:00
Why Skin May Be Your Most Honest Longevity Biomarker ... 00:08:52
Gut Health, Mitochondria & What Your Skin Reveals ... 00:14:15
Biological Age vs Chronological Age ... 00:19:08
Performance, Longevity & Resilience: Three Ways to Think About Aging ... 00:21:34
The Exosome Revolution: What Are Exosomes? ... 00:30:18
Why Most Consumers Ask the Wrong Questions About Exosomes ... 00:34:08
Platelet vs Stem Cell Exosomes Explained ... 00:38:03
Why Formulation Matters More Than Marketing ... 00:43:51
How Young Goose Built Their Exosome Formula ... 00:52:28
Formulation Science vs The Next "Miracle Ingredient" ... 00:59:21
Where Longevity Skincare Is Headed Next ... 01:08:48
Final Thoughts & Young Goose Discount Code ... 01:14:06
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Manukora Honey – A delicious real-food source of prebiotics, Manukora's high-MGO Manuka honey helps support your gut microbiome, digestion, and immune health with just one teaspoon a day. Head to MANUKORA.com/NAT to save up to 31% plus receive $25 worth of free gifts with the Starter Kit.
Electrolyze by BEAM Minerals - Electrolyze is a plant-based fulvic mineral formula that delivers a full spectrum of highly bioavailable trace minerals and electrolytes to support hydration, nutrient delivery, and cellular energy. Head to beamminerals.com/NAT20, use code NAT20, and get 20% off your first order.
Grass-Fed Whey Protein by Puori - A third-party tested, grass-fed whey protein delivering 21g of protein per serving, with every batch tested for over 200 contaminants and results available via a QR code for complete transparency. Head to puori.com/nat and use code NAT20 to get 32% off your first subscription order, plus a free premium shaker bottle.
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Dr. Bill Lawrence Episode

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Today, I’m joined by the insightful Dr. Scott Sherr, a pioneer in health optimization and mitochondrial medicine. In our conversation, Dr. Sherr introduces his groundbreaking concept—the "sympathetic spiral of doom"—and explains why so many high performers end up burned out, frustrated, and feeling like their nervous systems are working against them.

Give it a try at https://troscriptions.com/NATPODCAST or enter NATPODCAST at checkout for 10% off. Cannot be combined with any other offers.

Episode Timestamps:

Welcome and Introduction ... 00:00:00

Dr. Scott Sherr and the "Sympathetic Spiral of Doom" ... 00:00:42

Aging, Stem Cells, and Repair Strategies ... 00:01:21

Defining and Observing the Spiral in Practice ... 00:05:07

Mitochondrial Dysfunction and Chronic Stress ... 00:08:11

Why Rebuilding Energy Must Come First ... 00:12:00

High Performers, Burnout, and Overdoing Recovery ... 00:15:14

Symptoms and Effects of Burnout ... 00:16:30

Evaluating Energy, Metabolic Health, and Daily Stress ... 00:18:25

Methylene Blue: Immediate Mitochondrial Support ... 00:20:54

Clarifying: Not Stimulants, True Cellular Support ... 00:14:07

Differentiating Healthy Stress from System Overload ... 00:24:06

Oscillation Between Stress and Recovery ... 00:25:10

Signs You're Stuck in Chronic Sympathetic Mode ... 00:29:01

Sequence for Recovery: Energy, GABA, Immune, Sleep ... 00:54:06

Recognizing Progress and Returning to Capacity ... 01:00:44

Key Considerations for Methylene Blue ... 01:09:50

Anti-Aging, Recovery, and the Parasympathetic Edge ... 01:14:14

Our Amazing Sponsors:

Stemregen - A daily formula designed to support your body’s natural repair systems by helping release your own stem cells into circulation, supporting recovery, resilience, and whole-body renewal at the source. Visit stemregen.co/NAT15 and use code NAT15. 

MassZymes by BIOptimizers - A full-spectrum digestive enzyme formula with 4x more protease than leading competitors to help break down protein more efficiently so your body can actually use the amino acids you're eating. Head to bioptimizers.com/bionat and use code BIONAT for 15% off your order plus a free travel-size bottle of MassZymes (a $20 value) while supplies last.

Vita Zero-Age Exosomes by Vitali Skincare — a regenerative “stacking” formula with exosomes, GHK-Cu, niacinamide, and glutathione designed to support your skin at a cellular level rather than just the surface; go to www.vitaliskincare.com/?ref=Nat20 and use code NAT20 for 20% off.

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Dr. Bill Lawrence Episode

Today, I’m joined by Dr. Teo Soleymani, a renowned dermatological oncologist whose unique vantage point bridges the worlds of conventional medicine and longevity science. As someone who sees the real consequences of UV damage in his surgical practice while also advocating for a balanced, evidence-driven approach to sunlight and skin health, Dr. Teo Soleymani isn’t afraid to challenge the most entrenched ideas in modern skincare.

Listeners of this podcast can receive 15% off* of SunPowder when you go to drinksunpowder.com/NAT15 *Not available in combination with subscribe and save discount.

Episode Timestamps:

Podcast introduction and overview ... 00:00:00

Dr. Solemani’s clinical experience bridging conventional and wellness dermatology ... 00:05:18

Changing attitudes on sunlight: risks, benefits, and backlash ... 00:10:29

Genetic vs. environmental factors in skin cancer ... 00:11:22

Industry influence and cosmeceutical marketing in dermatology ... 00:12:28

Tan myths, burning, and the science of sun exposure ... 00:23:27

Sun “callus” and strategies for building UV tolerance ... 00:34:11

How to personalize safe sun exposure using minimal erythema dose (MED) ... 00:41:49

Best practices for sunscreen use and types to choose ... 00:43:54

Emergence of personalized and precision dermatology ... 00:51:04

Peptides: GHK-Cu, topical vs. injectable, and the science gap ... 00:56:03

Melanotan dangers and why to avoid ... 01:07:44

Innovations in oral skin protection—Sunpowder supplement ... 01:13:12

Sunpowder’s evidence, mechanism, and role as internal support ... 01:15:30

Smart sun practices, rapid-fire advice, and sign-off ... 01:24:01

Our Amazing Sponsors:

Qualia NAD+ by Qualia Life – Clinically proven to increase NAD+ levels by an average of 67% in just four weeks, Qualia NAD+ uses three highly bioavailable precursors to support cellular energy, mental clarity, metabolism, and healthy aging. Visit qualialife.com/nathalie and use code NAT

C.A.R.E. Mitochondrial Moisturizer by Young Goose – An upgraded cellular skincare formula featuring Methylene Blue and Liposomal Creatine to support mitochondrial function, skin barrier health, and resilient, hydrated skin. Click HERE and use code NAT10 to save on C.A.R.E. Mitochondrial Moisturizer.

Nature's Marvels Bioregulators by Profound Health - Natural bioregulators designed to support your body's own cellular communication and healthy aging, with targeted formulas for everything from brain and immune health to sleep and vitality. Click here and use code NAT15 for 15% off your first order.

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Dr. Bill Lawrence Episode

Today, I’m joined by Alex Kikel—a name that’s become synonymous with pushing the frontiers of biology, performance, and healing. Alex is the kind of person who, when told “there’s nothing more we can do,” responds with, “but what if that’s not true?” In our conversation, he shares the pivotal moments that made him question everything about the standard approach to health, including his personal story of reversing serious conditions when traditional solutions failed.

Episode Timestamps:

Introduction to podcast vision and focus ... 00:00:00

Importance of foundational practices before advanced interventions ... 00:07:15

Overlooked basics in cancer and chronic disease: oxygen and CO2 ... 00:08:28

Power of mindset and plasticity in overcoming illness ... 00:11:27

Limits of the medical model and need for new frameworks ... 00:13:24

Pattern recognition: side effect tracking over diagnosis ... 00:15:05

TBI, brain healing: ketones, hydrogen, and personalized support ... 00:17:08

Brain fuel sources and stacking for neurorecovery ... 00:19:26

Dosing lessons from experimentation and case tracking ... 00:23:00

BPC157 reactions and bioindividuality ... 00:27:08

Hormones, mitochondria, and interconnected healing systems ... 00:38:33

HRT for women vs. men—different challenges and approaches ... 00:39:40

Microtubules, consciousness, and upstream healing ... 00:43:28

Mitochondrial peptides: dosing, overspin, and autoregulation ... 00:45:25

Cautions before peptides: effective second-tier supplements ... 00:55:44

Sulforaphane: clinical power and person-specific cautions ... 00:57:29

Neurodegeneration: combining fueling, signaling, and inflammation ... 01:02:16

Disuse and under-stimulation as causes of brain aging ... 01:06:48

Movement, oxygen use, and patterns in chronic disease ... 01:09:10

Treading the line between innovation and risk ... 01:11:20

Challenging lipid dogma; focus on oxidation/mitochondria ... 01:14:17

True longevity as fit span and living well ... 01:15:51

Most impactful change: invest in relationships ... 01:16:26

Our Amazing Sponsors:

LongeFera by Regenerive™- A precision-formulated ashwagandha supplement that isolates four key bioactive compounds to support a healthy stress response, cognitive function, balanced inflammation, and cellular longevity—without the fillers and inconsistent extracts found in many products. Head to regenerive.co and use code NAT25 for 25% off your order.

Wolverine Formula by LVLUP Health – A peptide-based formula designed to support recovery, tissue repair, and musculoskeletal health, helping your body bounce back from workouts and everyday wear and tear. Click HERE and use code NAT for 15% off your order.

Mitopure Gummies by Timeline – Supports healthier cellular energy, muscle strength, recovery, and healthy aging with clinically proven Urolithin A—without artificial sweeteners, colors, flavors, or unnecessary fillers. Head to timeline.com/NAT20 to get Mitopure starting at just $99 and save an additional 20% on your order.

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Dr. Bill Lawrence Episode

Today, I’m joined once again by the innovative Ian Mitchell, a name familiar to anyone passionate about radical longevity, biohacking, and pushing the boundaries of human performance. In this conversation, Ian pulls back the curtain on the science and surprising applications of C60—known as the “buckyball” molecule—and why it’s become such a powerful tool for both peak performance and healthy aging.

Click HERE and use code NAT15 for 15% off Ian’s amazing formulations

Previous Episodes:

#287: Ian Mitchell: Unlocking Longevity: The Power of Energy and Oxygen

#329: How C60 Is Changing Aging: Energy, Brain Health, and Recovery Insights With Ian Mitchell

#172: Wizard Sciences: Biohacking for Peak Performance with C60

Episode Timestamps:

Introduction and podcast mission ... 00:00:00

C60 discovery and properties ... 00:04:34

Industrial vs. health applications of C60 ... 00:05:23

C60 rat study and insights on longevity ... 00:13:41

Human and animal C60 experiences ... 00:17:30

C60 supplementation dosing strategies ... 00:21:06

Muscle fiber recruitment and athletic benefits ... 00:24:51

Formulation differences: oil types and targeted effects ... 00:27:10

Stepwise approach to inflammation and brain support ... 00:29:06

Compounds added to C60 products (NMN, CoQ10, etc.) ... 00:33:28

C60 and neurodegeneration mechanisms ... 00:48:55

EMFs, neural inflammation, and mitigation ... 00:53:30

Optimal dosing and why cycling C60 matters ... 01:00:57

Emerging research: stem cells and diabetes ... 01:02:53

Where to find C60 and additional resources ... 01:10:01

Our Amazing Sponsors:

Blue Cannatine by Troscriptions – Combining methylene blue with carefully selected nootropics in a fast-acting troche, Blue Cannatine helps support concentration, productivity, and flow-state performance whether you're working, creating, or tackling a demanding day. Give it a try at troscriptions.com/NATPODCAST or enter NATPODCAST at checkout for 10% off your first order. (Not valid when combined with other offers)

O₃RACLE by Wizard Sciences — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; Click HERE and use code NAT15 for 15% off.

Daily Gut Detox by Just Thrive Health – A science-backed detox powered by clinically proven immunoglobulins that bind and remove toxins while supporting your gut, immune system, and digestion—without harsh flushing or discomfort. Visit JustThriveHealth.com/NAT20 and use code NAT20 for 20% off your order, risk-free.

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Dr. Bill Lawrence Episode