LONGEVITY with Nathalie Niddam

Today, I'm sitting down with Dr. Gus Vickery, a good friend and one of my favorite collaborators when it comes to cutting-edge insights in personalized health and longevity. In this episode, I put myself under the microscope as we walk through my own metabolomics testing after a period of heavy travel, stress, and—yes—a break from my usual supplement routine. If you've ever wondered whether skipping your foundational health habits "just for a little while" really matters, you're about to find out.

If you are a clinician and would like to offer the Aristotle test to your patients please use this link to learn more about the Theriome test: therio.me/niddam 
If you are a patient and would like to run the Theriome Aristotle test and get a full interpretation and protocol based on your results from Dr Vickery & his team please use this link: https://authentichealth.com/precision-health-evaluation/
 
Episode Timestamps:
Introduction to Longevity Podcast and episode overview ... 00:00:00
Metabolomics and interpreting health data – practitioner guidance needed ... 00:05:05
Combining metabolomics, gut, and blood data for whole-system insights ... 00:06:02
Nutrient depletion and oxidative stress: critical findings ... 00:18:57
Supplementation essentials for aging well ... 00:27:05
Metabolomics comparison by age group and optimization goals ... 00:29:03
Stacking interventions: why less is more with diagnostics ... 00:31:05
Functional health markers and the value of context ... 00:34:47
Sympathetic dominance, mindset, and impact on longevity ... 00:35:26
Restoring nervous system balance – inner work and tech tools ... 00:42:38
Toxins, heavy metals, and practical detox strategies ... 00:49:11
Clean environment, resiliency, and realistic lifestyle shifts ... 00:55:29
Key nutrient deficiencies revealed by metabolomics ... 01:09:15
Genetic and metabolomic tests: what's actionable? ... 01:15:07
Hope for the future: human resilience and expanding technology ... 01:22:24
Weekly actionable: walk outside for mitochondria and stress relief ... 01:26:55
 
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Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to profound-health.com and use code NAT15 for 15% off your first order.

Blue Peptide Spray from Young Goose brings the message back loud and clear. With NAD+ APEX to refuel energy, methylene blue to recharge your mitochondria, and GHK-Cu to tell your skin, "Hey, start making that collagen again!" It's longevity science, not cosmetic hype. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer.
 
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Today, I'm joined by the remarkable Dr. Gabrielle Lyon, a pioneer in redefining the longevity conversation by making muscle health—not weight—the centerpiece of aging well. With a background in geriatrics and nutritional sciences, she illuminates why the quality of your muscle tissue is a far more powerful predictor of health than any number on the scale. Her perspective challenges the notion of a "healthy sedentary person" and reveals the major role of intramuscular fat in metabolic dysfunction. Check out her book The Forever Strong Playbook. 
 
Episode Timestamps:
Introduction, podcast focus, and welcoming Dr. Gabrielle Lyon ... 00:00:00
Muscle's impact on brain health, inflammation, and healthy aging ... 00:01:03
Dr. Lyon's childhood, grit, and self-discipline ... 00:04:33
Mentorship and protein science under Dr. Donald Lehman ... 00:07:05
Muscle as the overlooked metabolic organ ... 00:08:45
Why intramuscular fat matters more than body weight ... 00:10:06
Plant vs. animal protein for muscle health ... 00:13:29
Muscle as an endocrine organ and cognition ... 00:16:21
Future of muscle science: anabolics, imaging, and technology ... 00:18:22
GLP-1s, sarcopenic obesity, and muscle-first protocol ... 00:46:45
Sarcopenia, aging, and the importance of early training ... 01:04:35
Building lifelong resilience—mental and physical ... 01:08:31
Predictions: anabolics, muscle testing, and assessment ... 01:12:17
"Strength is a responsibility, not a luxury" ... 01:13:53
 
Our Amazing Sponsors:
Cozy Earth – Thoughtfully designed bedding and bath essentials that turn your home into a calm, elevated retreat and actually hold up wash after wash. Give your space a reset at cozyearth.com with code LONGEVITY for up to 20% off, and don't forget to mention this podcast in the post-purchase survey.
 
Ozlo - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT to get $75 off.

Tranq Dart by Wizard Sciences - a multi-pathway sleep support from Wizard Sciences. It's not a knockout pill; it's a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Visit wizardsciences.com and use code NAT15 for 15% off. Sleep smarter, not harder.
 
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Today, I'm joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators.
 
Use code NAT10 for 10% off products at https://alchemiqlabs.com/
 
Episode Timestamps:
Welcome and episode introduction ... 00:00:00
Anthony Castore's path from strength coaching to cellular medicine ... 00:05:55
Connecting strength training with cellular pathways (AMPK, mTOR) ... 00:12:27
Explaining and balancing AMPK and mTOR for performance ... 00:13:03
Training strategies: Metabolic, hypertrophy, and neural approaches ... 00:18:18
Building a solid foundation: Lifestyle, training, nutrition, peptides ... 00:23:04
Assessing recovery capacity and individualizing protocols ... 00:26:02
Mitochondrial fission, fusion, and targeted adaptation ... 00:29:57
Optimizing muscle gain and fat loss through calories and recovery ... 00:31:00
Differentiating bodybuilder vs. longevity approaches ... 00:34:44
Integrating peptides and support molecules into routines ... 00:40:44
Ketone esters and mitochondrial peptide interventions ... 00:41:20
Cautions on stacking and combining interventions ... 00:54:04
Lessons learned from overdoing interventions ... 01:05:02
 
Our Amazing Sponsors:
Vitali - combines pharmaceutical-grade copper peptides with zero-age exosomes to support clearer cellular signaling and long-term skin resilience, working with your biology instead of forcing change. Visit VitaliSkincare.com and use code NAT20 for 20% off.
 
BEAM Minerals - Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at beamminerals.com with code NAT20.
 
Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go to lvluphealth.com and use code NAT for 20% off.
 
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Today, I'm joined by the deeply thoughtful and refreshingly honest Dr. Sanjay Bhojraj, a self-described "curious cardiologist" who spent decades treating heart attacks in the cath lab — before stepping away to ask a bigger question: Why are we waiting for the crisis instead of preventing it?
 
Episode Timestamps:
Welcome to Longevity & episode setup … 00:00:00
Dr. Bhojraj's shift from ER cardiology to prevention … 00:06:30
Why most heart attacks aren't caused by big blockages … 00:09:15
Stress, nervous system load & heart attack risk … 00:13:10
CIMT explained: what it measures (and what it misses) … 00:26:40
Calcium scores vs CT angiograms … 00:35:45
CLEERLY scan: seeing dangerous soft plaque … 00:38:45
Can plaque actually regress? … 00:41:55
When heart scans make patients less afraid … 00:44:05
When should you test — even without symptoms? … 00:45:50
Why age 45 is a major cardiovascular inflection point … 00:47:10
Hormones, estrogen loss & women's heart risk … 00:50:10
Why cardiology still misunderstands women … 00:54:30
Small dense LDL, ApoB & oxidized cholesterol … 01:02:00
Why fixing inflammation matters more than numbers … 01:05:50
 
Our Amazing Sponsors:
Regenerive - Built around clinically validated Longufera (Ash X4) to support core aging pathways—so it's not just "healthy aging" in theory. Go to regenerive.co and use code NAT25 to save 25%
 
Mitopure® Longevity Gummies are the only clinically proven Urolithin A gummies supporting mitochondrial health — one of the key hallmarks of aging. Get 35% off a one-month subscription at Timeline.com/Nat2026 *Special deal through January 2026.
 
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Today, I'm joined by Charles Bohdy, a true innovator in water purification technology, and Victor Sagalovsky, a passionate advocate for bringing the science of water quality into our daily lives. Together, we take a deep dive into the unseen world of the water running through our homes—exploring not just its purity, but its hidden potential to support our biology in ways most of us have never considered.
Whole HOME Water System - Use code NAT100
 
Episode Timestamps:
Intro to Longevity Podcast and today's water focus ... 00:00:00
Water system's health benefits and testing ... 00:01:33
Why water quality is overlooked yet critical ... 00:07:20
Common water issues and municipal limitations ... 00:09:10
Filtration methods: carbon blocks and pathogens ... 00:15:26
Charles's nano-ceramic multilayer filters ... 00:20:14
Concerns with chlorine and fluoride in water ... 00:23:44
Retaining healthy minerals: charge-based filtration ... 00:35:18
Reverse osmosis: pros, cons, and fungal risks ... 00:50:49
Structured water's role in biological health ... 00:56:53
Water structuring: agricultural validation ... 01:00:21
Whole-home filtration: installation and costs ... 01:11:02
Closing thoughts: bringing nature's water home ... 01:25:00
 
Our Amazing Sponsors:
Regenerive - Built around clinically validated Longufera (Ash X4) to support core aging pathways—so it's not just "healthy aging" in theory. Go to regenerive.co and use code NAT25 to save 25% 
Primeadine by Oxford Healthspan: Primeadine supports autophagy — your cells' natural renewal and cleanup process — using food-derived spermidine, no fasting required. If you want to support resilience from the inside out, head to https://www.oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout (one-time purchases only).
Ozlo - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT to get $75 off.
 
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