LONGEVITY with Nathalie Niddam

Today, I'm joined by Erin Ryan, my producer, for a special follow-up episode where we tackle your most pressing questions about bioregulators and peptides. After the wildly popular Bill Lawrence interview, the Longevity Podcast community sent in a wave of thoughtful queries—from cancer concerns to menopause, sourcing, and practical tips.
Click Here for list of BIOREGULATOR NAMES
 
Books mentioned in this episode:
The Peptide Bioregulator Revolution (Great primer on bioregulators)
Author: Dr. Marios Kyriazis
Peptides and the Epigenetic Control of Aging  (Technical, science-heavy)
Author: PhD Vladimir Khavinson, MD, PharmaB Phil Micans, MS, PhD Alexander Maryanovich, MD 
 
Episode Timestamps:
Welcome and sponsor introduction ... 00:00:00
Autophagy and Primadene ... 00:00:44
Bioregulator basics and liver support ... 00:01:58
Cancer and telomere lengthening peptides ... 00:05:56
Bioregulators and cancer: caution advised ... 00:08:06
Immune bioregulators and cancer recovery ... 00:12:31
Book reference: "Peptide Bioregulator Revolution" ... 00:13:54
Bioregulators for immune support ... 00:14:44
When not to use bioregulators ... 00:16:56
Menopause, ovarian aging, and bioregulators ... 00:17:47
Clinical outcomes in women ... 00:23:57
GLP-1s and bioregulator absorption ... 00:27:01
Preventative strategies by age ... 00:28:57
Epitalon safety and dosing ... 00:33:18
Bioregulator sourcing and access ... 00:35:41
Amazon caution for supplements ... 00:38:01
Emerging science and trusted brands ... 00:40:03
Social media challenges and newsletter ... 00:44:30
 
Our Amazing Sponsors:
Primeadine by Oxford Healthspan — A food-derived spermidine supplement that supports autophagy and cellular renewal without fasting, made from Japanese wheat germ with clean, rigorously tested ingredients (including a gluten-free option); visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout.
 
Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to profound-health.com and use code NAT15 for 15% off your first order.   http://www.profound-health.com/?Aff=Longevity15
 
O₃RACLE by Wizard Sciences — A daily ozonated oil capsule designed to support immune balance, cellular communication, and antioxidant production without clinics, machines, or complicated routines; learn more at wizardsciences.com and use code NAT15 for 15% off.
 
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Dr. Bill Lawrence Episode

Today, I'm joined by the insightful Dr. Nafysa Parpia, a true leader in environmental and complex chronic illness medicine and the Director of Naturopathic Medicine at Gordon Medical. In our conversation, Dr. Parpia shares how her passion for deep, integrated healing brought her into the world of environmental toxins, hormone health, and the nuanced ways our bodies respond to the modern world. She opens up about her journey, the unique challenges women face—especially during menopause—and why so many aren't finding answers in traditional medicine.
 
Episode Timestamps:
Welcome & episode goals ... 00:00:00
Environmental toxins and complex illness ... 00:01:17
Rise of chronic illnesses; environmental triggers ... 00:07:26
Lead, bone loss, and menopause ... 00:10:03
Sources of lead exposure today ... 00:12:03
Chelation therapy: what, when, and how ... 00:14:26
Opening detox pathways: herbs and bioregulators ... 00:17:17
Menopause, toxic burden, and immune shifts ... 00:20:49
CDC data: multiple toxins and cumulative risk ... 00:23:02
Genetics, nutrition, and susceptibility ... 00:28:12
Personalized medicine & system constraints ... 00:30:03
Heavy metals, inflammation, and hormone effects ... 00:35:35
Peptide and bioregulator therapy: sequencing matters ... 00:41:12
Testing mistakes: over- and under-testing ... 00:57:41
Preparing for detox: the Pretox approach ... 01:02:58
Sensitivity to binders and protocol adjustments ... 01:16:50
Plasmapheresis (TPE): science and application ... 01:19:19
Optimizing menopause care and women's self-sovereignty ...  01:25:28
 
Our Amazing Sponsors:
STEMREGEN - A plant-based formula designed to support your body's natural stem cell release, circulation, and repair processes so you can recover and regenerate more effectively. Visit www.stemregen.co/nat and use code NAT15 for your exclusive discount.
 
Magnesium Breakthrough by BIOptimizers — A full-spectrum magnesium supplement combining seven highly absorbable forms to support sleep, stress, muscle recovery, and nervous system balance in one nightly habit. Save 15% at bioptimizers.com/bionat with code BIONAT
 
Youth Daily by Young Goose — An all-in-one moisturizer powered by NAD+ nano precursors to boost elasticity, smooth wrinkles, and keep your skin looking fresh, dewy, and full of life; grab yours HERE and use code Nat10
 
 
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Dr. Bill Lawrence Episode

Today, I'm joined by the legendary Dr. Jeffrey Bland, widely known as the "father of functional medicine" and a true pioneer in the science of longevity and immune resilience. In this conversation, Dr. Jeffrey Bland opens up about his decades-long journey questioning the conventional medicine model, the personal moments that shaped his mission, and how his passion for asking the right questions ultimately led him to reshape the future of healthcare.
Visit Bigboldhealth.com/NAT and get 15% off automatically at checkout.
 
Episode Timestamps:
Focus on immune system aging ... 00:00:00
Questioning conventional medicine and the roots of chronic disease ... 00:05:00
Functional medicine and influences like Linus Pauling ... 00:12:39
Dangers of oversimplification and the limits of biohacking ... 00:17:21
Evolving thinking on supplements and the power of cycling and personalization ... 00:19:37
Why immune resilience trumps immune boosting for longevity ... 00:25:21
Diet's impact on immune cell turnover and long-term health ... 00:28:57
Autoimmunity, CHIP cells, inflammaging, and biological individuality ... 00:32:04
Microbiome, mitochondria, and immune-driven fatigue ... 01:00:07
The 4R gut and immune program as a starting point ... 01:06:26
Movement, lymphatics, and rejuvenation ... 01:08:35
Food as information, epigenetics, and practical recommendations ... 01:11:25
90-day immune system renewal and rapid-fire takeaways ... 01:31:40
 
Our Amazing Sponsors:
Quantum Upgrade - Supports nervous system balance without wearables or apps—just effortless, 24/7 quantum energy streaming. With 21+ studies showing measurable improvements in stress and cellular function, it's easy to try for yourself. Visit quantumupgrade.io/NAT and use code NAT15 to start the free 15 day trial.
 
Primeadine by Oxford Healthspan — A food-derived spermidine supplement that supports autophagy and cellular renewal without fasting, made from Japanese wheat germ with clean, rigorously tested ingredients (including a gluten-free option); visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout.
 
PW1 by Puori — A clean, high-quality whey protein that's third-party tested for over 200 contaminants and smooth enough to feel like a treat while supporting muscle, metabolism, and bone strength. Go to puori.com/NAT and use code NAT for 32% off your first subscription or 20% off anything on the site.

 
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Dr. Bill Lawrence Episode

Today, I'm joined by Dr. Aimie Apigian, an innovative leader in the biology of trauma, whose work bridges the worlds of science, medicine, and lived experience. In our conversation, Dr. Apigian opens up about her journey from conventional medicine—where symptom management was the norm—to uncovering the physiological roots of trauma and the crucial role our nervous system plays in resilience and healing. She shares how her own health struggles, her work with adopted children, and a relentless curiosity led her to re-examine everything she thought she knew about stress, autoimmunity, and capacity.
The 7-Day Somatic Healing for Stored Emotions - https://traumahealingaccelerated.mykajabi.com/a/2148170319/wdrhGYaY
21-Day Journey, a daily live session program that helps participants understand how much trauma their body may be holding - https://traumahealingaccelerated.mykajabi.com/a/2147704575/wdrhGYaY

Episode Timestamps:
Introduction, host's mission, and episode theme ... 00:00:00
Science behind trauma, limits of traditional medicine, and autoimmune experiences ... 00:06:11
Attachment, symptom management, functional medicine, and healing journey ... 00:08:17
Mold exposure, state triggers, brain inflammation, and capacity blocks ... 00:14:22
Medical gaslighting, trauma validation, and biological capacity ... 00:18:25
Safety, resilience, and chronic survival state effects ... 00:19:32
Misconceptions about chronic stress—emergency brake and vagus nerve ... 00:22:27
Attachment patterns, autoimmunity, and shrinking world ... 00:28:47
Chronic survival loop, exhaustion, coping strategies, and shutdown ... 00:31:11
Moving to repair: phases of healing and gentle approaches ... 00:34:08
Somatic practices, art therapy, and different expressions of trauma ... 00:39:01
Shifts in sleep, digestion, anxiety, and felt safety ... 00:42:06
Tracking nervous system state: strategies and awareness ... 00:46:41
Therapy limitations: biology and somatic integration ... 00:48:42
Retraining vs. managing symptoms, stabilization, and healing ... 00:54:53
Capacity, resilience, lessons from centenarians, and longevity ... 01:00:06
Trauma's impact on mitochondria, telomeres, and generational health ... 01:06:27
Gut microbiome and trauma: two-way connection ... 01:08:03
 
Our Amazing Sponsors:
Manukora Honey - rich, creamy Manuka honey packed with powerful bioactives, all in just one heaped teaspoon a day. Go to MANUKORA.com/NAT to save up to 31% plus $25 in free gifts with the Starter Kit.
 
Mitopure Longevity Gummies by Timeline — Clinically backed Urolithin A supports mitochondrial health to boost energy, recovery, and healthy aging, all in an easy daily gummy instead of another pill; go to timeline.com/nat20 for 20% off Mitopure Gummies.
 
Ozlo - use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT to get $75 off.

 
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Dr. Bill Lawrence Episode

Today, I'm joined by the inspiring Leslie Kenny, Oxford-based longevity expert and a living example of turning adversity into vitality. After being told at 39 that she had lupus, rheumatoid arthritis, and just five years to live, Leslie defiantly forged a new path—reversing her diagnoses, restoring her thyroid health, and even welcoming a healthy baby girl at 43. Her story is a testament to the power of questioning the status quo, honoring the wisdom within our bodies, and refusing to accept decline as inevitable.
 
Leslie has a generous offer for you, when you visit oxfordhealthspan.com/BIONAT20 and use code BIONAT20 at checkout you'll get 20% off.
 
Episode Timestamps:
Welcome, show intro, and overview ... 00:00:00
Leslie Kenny's health journey and reversing disease ... 00:00:30
Biological vs. chronological age and the immune system ... 00:04:55
Impact of trauma and stress on aging ... 00:11:51
Overcoming prognosis: lifestyle and scientific interventions ... 00:18:02
Diet, tracking, and removing triggers ... 00:22:21
The overlooked importance of thyroid health ... 00:32:23
Dangers of overdoing fasting and hormesis ... 00:40:21
Autophagy basics and the cellular cleanup crew ... 00:44:06
Spermidine's role, sourcing, and supplement quality ... 01:10:19
 Optimizing longevity habits and daily routines ... 01:29:44
 
Our Amazing Sponsors:
Tro Zzz by Troscriptions – A fast-acting sleep troche that dissolves in your cheek and combines melatonin with compounds like honokiol, adenosine, cordycepin, CBD, CBN, and 5-HTP to support deep, restorative sleep when travel, stress, or late workouts throw things off. Head to troscriptions.com and use code NAT10 for 10% off your first order. 
 
BEAM Minerals - Low energy often starts in the mitochondria. Support cellular energy with a bioavailable liquid mineral supplement — and get 20% off at beamminerals.com with code NAT20.

Nature's Marvels Bioregulators - provide gentle, organ-specific support — and the Liver Bioregulator is a favorite this season for supporting detox pathways and metabolic flow. Head to http://www.profound-health.com/?Aff=Longevity15 and use code NAT15 for 15% off your first order.

 
Nat's Links: 
YouTube Channel
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Dr. Bill Lawrence Episode