Longevity Optimization with Kayla Barnes-Lentz

Most anti-aging skincare focuses on wrinkles after they appear. Skin longevity starts much earlier, with the biology that determines how well skin repairs itself, maintains collagen, responds to hormones, and clears damaged or senescent cells.
Optimize your sleep with the Eight Sleep Pod. 
Get up to $350 off at https://www.eightsleep.com/Kayla with code “KAYLA”
I sat down with Dr. Saranya Wyles, MD, PhD, a Mayo Clinic dermatologist and regenerative medicine researcher, to separate useful science from a category full of hype. We cover sunscreen, visible light, facial estrogen, exercise, sauna, Botox, microcurrent, radiofrequency, retinol, exosomes, and the treatments that may support healthier skin over time.
We also explore why women's skin changes during menopause and across the menstrual cycle, how bone and facial fat influence visible aging, and why the right intervention depends on the decade, the tissue, and the problem you are actually trying to solve.
Track your sleep, recovery, strain, and HRV with WHOOP. Get one month free at https://join.whoop.com/kaylabarnes
Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.
https://kayla-barnes-lentz.circle.so/female-longevity-community
In This Conversation:
How senescent cells affect skin aging and repair

Why menopause accelerates collagen and skin changes

What sunscreen, antioxidants, and physical barriers actually do

Botox, facial exercises, microcurrent, and in-office devices

Retinol, exosomes, PRP, and regenerative skincare

How exercise, sleep, sauna, and the microbiome affect skin

Connect with Kayla:

Instagram: https://www.instagram.com/kaylabarnes/
TikTok: https://www.tiktok.com/@femalelongevity
Twitter:https://x.com/femalelongevity
Website:https://www.kaylabarnes.com/
Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054
Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227
Follow Her Female Protocol: https://www.protocol.kaylabarnes.com

Learn More About Dr. Saranya Wyles:
Mayo Clinic Profile: https://www.mayoclinic.org/biographies/wyles-saranya-p-m-d-ph-d/bio-20518649
Instagram: https://www.instagram.com/drwyles.derm/
LinkedIn: Saranya Wyles, M.D., Ph.D. | LinkedIn
X: https://x.com/drwyles_derm
#femalelongevity #skinlongevity #dermatology #senescentcells #skinaging #sunscreen #longevity #skincareroutine #hormonehealth #wellness

We're pregnant with our first baby, and there is a lot more to share than the announcement. From how long it took us to conceive to the moment we saw a positive test, this is the personal side of a journey I have spent years preparing for.
Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.
https://kayla-barnes-lentz.circle.so/female-longevity-community
Support lean muscle and recovery with PerfectAmino essential amino acids: https://bodyhealth.com/products/perfectaminoUse code “kayla20” for 20% off.
Take a longevity approach to skincare with OS-01, the peptide that targets senescent cells.
Get OneSkin at oneskin.co/KAYLA with code “KAYLA”.
My husband, Warren, joins me to answer your questions about conceiving naturally, why we previously froze eggs and created embryos, and the changes we made while trying. We also share how my wearable data gave me an early clue, how I told Warren, and what has already changed in my sleep, meals and daily routine.
We talk about the family we hope to build, our early thoughts on birth and parenting, and the conversations we are having as we prepare to become mom and dad. We also open up about getting married quickly, learning to communicate, our marriage meetings, and the role our Christian faith plays in our life together. We are still figuring plenty of this out, and I wanted to share that part of the story, too.
In this conversation:
How long it took us to conceive and why this pregnancy was not through IVF

Warren's sperm testing and decision to pause sauna while we were trying

The early signs I noticed before taking a pregnancy test

Changes to my sleep, food and exercise plans

Our thoughts on birth, breastfeeding and life with a newborn

Would you like a part two? Leave the question you would most like Warren and me to answer next.

Connect with Kayla:

Instagram: https://www.instagram.com/kaylabarnes/
TikTok: https://www.tiktok.com/@femalelongevity
Twitter:https://x.com/femalelongevity
Website:https://www.kaylabarnes.com/
Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054
Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227
Follow Her Female Protocol: https://www.protocol.kaylabarnes.com
Connect with Warren:Instagram: https://www.instagram.com/warrenlentz/
Website: https://heavenlyheatsaunas.com/

#PregnancyJourney #KaylaBarnes #LongevityOptimization #TryingToConceive #PreconceptionHealth #FirstPregnancy #Marriage #Parenthood

Menopause does not begin when periods stop. Ovarian reserve and egg quality have been declining for decades, and that decline accelerates for many women in their late 30s.
I sat down with Kutluk Oktay, MD, PhD, FACOG, a reproductive endocrinologist, ovarian biologist, and pioneer in ovarian tissue cryopreservation and transplantation. He explains why women are born with the eggs they will ever have, what changes after age 37, why adult ovaries do not appear to regenerate eggs, and why one AMH result should not be treated as a complete picture of ovarian reserve.
Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.
https://kayla-barnes-lentz.circle.so/female-longevity-community
Optimize your sleep with the Eight Sleep Pod. 
Get up to $350 off at https://www.eightsleep.com/Kayla with code “KAYLA”

Track your sleep, recovery, strain, and HRV with WHOOP. Get one month free at https://join.whoop.com/kaylabarnes
We also discuss ovarian tissue cryopreservation, a procedure he helped establish for medical fertility preservation. His team is now studying whether tissue frozen earlier in life and transplanted later could extend ovarian function and delay menopause. We cover what is already established, what remains investigational, when the procedure may offer more benefit, and how growing follicles in the lab could eventually change IVF.
In this conversation
-Why ovarian aging accelerates after age 37
-What AMH measures and why one test can mislead
-How PMOS can affect ovulation and ovarian reserve
-What ovarian tissue freezing can and cannot do
-Why menopause delay remains investigational
-How future IVF may avoid ovarian stimulation

Connect with Kayla:
Instagram: https://www.instagram.com/kaylabarnes/
TikTok: https://www.tiktok.com/@femalelongevity
Twitter:https://x.com/femalelongevity
Website:https://www.kaylabarnes.com/
Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054
Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227
Follow Her Female Protocol: https://www.protocol.kaylabarnes.com

Instagram: ⁠https://www.instagram.com/innovation_fertility_pc⁠
X: ⁠https://x.com/kutlukoktay⁠
Yale profile: https://medicine.yale.edu/profile/kutluk-oktay/
Oktay Lab: https://medicine.yale.edu/lab/oktay/
Innovation Fertility Preservation and IVF: https://www.fertilitypreservation.org/
Menopause delay research: https://www.fertilitypreservation.org/contents/fertility-preservation-details/menopausedelay
NoPauze calculator: https://www.fertilitypreservation.org/contents/probability-calculator/nopauze-calculator
2024 menopause-delay modeling study: PubMed PMID 38184290
#FemaleLongevity #OvarianAging #Menopause #FertilityPreservation #OvarianReserve #ReproductiveLongevity #WomensHealth #AMH #PMOS #IVF

Most skincare is designed to improve how aging looks. But can it change what is happening inside the skin itself?
In this conversation, I sit down with Carolina Reis Oliveira, PhD, co-founder and CEO of OneSkin, to explore what actually drives skin aging at the cellular level. Carolina explains how senescent “zombie” cells, UV exposure, inflammation, hormonal changes and a weakened skin barrier affect how skin functions, not just how it looks.
Get OneSkin's new Rich Cream and the rest of the OS-01 line at:
oneskin.co/KAYLA with code KAYLA.
We break down the benefits and limitations of retinol, why chronic redness and flaking are not signs that a product is working better, and whether popular ingredients such as NAD+ precursors, methylene blue and GHK-Cu can penetrate the skin and remain stable. We also discuss collagen supplementation, red light therapy, hyperbaric oxygen, sauna, exercise, sun exposure and the relationship between skin-barrier health and systemic inflammation.
Carolina also shares the science behind OneSkin's OS-01 peptide and its new Face Rich Cream, including findings related to collagen, hyaluronic acid, elastin, filaggrin, hydration, firmness and fine lines.
In this conversation:
-Why many anti-aging products target visible symptoms rather than the biology of skin aging
-How senescent “zombie” cells contribute to inflammation and tissue decline
-How to use retinol without chronically damaging the skin barrier
-Why ingredient penetration, stability and formulation matter
-How skin-barrier dysfunction may affect inflammation throughout the body
-What collagen, red light, hyperbaric oxygen, sauna and exercise can do for the ski
- What OneSkin found when testing GHK-Cu copper peptides
-Why moisturizer alone may not solve age-related dryness
-How OS-01 is designed to target the underlying biology of skin aging

Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.
https://kayla-barnes-lentz.circle.so/female-longevity-community
Optimize your sleep with the Eight Sleep Pod. 
Get up to $350 off at https://www.eightsleep.com/Kayla with code “KAYLA”
Support lean muscle and recovery with PerfectAmino essential amino acids: https://bodyhealth.com/products/perfectamino“Kayla20”

Connect with Kayla:
Instagram: https://www.instagram.com/kaylabarnes/
TikTok: https://www.tiktok.com/@femalelongevity
Twitter:https://x.com/femalelongevity
Website:https://www.kaylabarnes.com/
Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054
Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227
Follow Her Female Protocol: https://www.protocol.kaylabarnes.com
Connect with Carolina Reis Oliveira:
Instagram: https://www.instagram.com/carolina.reis.phd/
LinkedIn: https://www.linkedin.com/in/carolina-reis-oliveira-a69b8a27/
X: https://x.com/Carol_roliveira
Learn more about OneSkin:
Shop OneSkin: https://oneskin.pxf.io/LKgxy0
Website: https://www.oneskin.co/
Instagram: https://www.instagram.com/oneskin.co/
LinkedIn: https://www.linkedin.com/company/oneskin/
Scientific publications: https://www.oneskin.co/pages/scientific-publications

#SkinLongevity #SkinHealth #HealthyAging #OneSkin #Retinol #SenescentCells #FemaleLongevity #KaylaBarnes

Most longevity conversations focus on the brain, heart, muscle, and metabolism. Far less attention goes to the thymus, an immune organ that starts shrinking almost as soon as puberty ends, and new research suggests it may be quietly linked to fertility, hormones, and even how millions of women taking birth control are aging on the inside.
I sit down with Dr. Abud Bakri, a board-certified internal medicine physician and hospitalist who founded Systems, a performance and longevity practice built around treating the body system by system rather than symptom by symptom.
We start with the foundations that determine whether any advanced intervention can actually work: light exposure, circadian timing, mitochondrial health, metabolic function, and the parts of modern life working against all of it.
Then we get into the thymus itself: why it shrinks after puberty, what that has to do with an unexpected finding in ovarian development, and a harder question Dr. Bakri raises about whether birth control may be accelerating that shrinkage in ways no one is currently studying.
We close on peptides: why Dr. Bakri treats them like drugs rather than supplements, what separates receptor-based peptides from the ones we understand far less, what we actually know about BPC-157, thymosin alpha-1, SS-31, and GHK-Cu, and how a peptide protocol could eventually be timed to a woman's cycle instead of applied the same way to everyone.
Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.
https://kayla-barnes-lentz.circle.so/female-longevity-community
Optimize your sleep with the Eight Sleep Pod. 
Get up to $350 off at https://www.eightsleep.com/Kayla with code “KAYLA”

Connect with Kayla:

Instagram: https://www.instagram.com/kaylabarnes/
TikTok: https://www.tiktok.com/@femalelongevity
Twitter:https://x.com/femalelongevity
Website:https://www.kaylabarnes.com/
Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054
Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227
Follow Her Female Protocol: https://www.protocol.kaylabarnes.com
Connect with Dr Abud:
Instagram: https://www.instagram.com/abud_bakri/
Website: https://abudbakri.com/ X: https://x.com/AbudBakri