Episode 86: Vitamin B12 | Solving The Pernicious Anaemia Mystery
The first medical description of pernicious anaemia is from 1821. It is written by Dr James Combe and describes a previously well 47 year old corn-merchant who presented with pallor, weakness, and neurological symptoms. It would take over a hundred years before we would know how to treat this condition, and another decade after that to understand why the treatment worked. Vitamin B12 is an essential component of our diet and only found in animal products. Deficiency in vitamin B12 can present with fatigue, anaemia (macrocytic), and neurological symptoms. The most at risk from a dietary perspective are vegetarians, vegans, and the elderly. Patients may also have an autoimmune condition (pernicious anaemia) that interferes with gastric parietal cells and intrinsic factor; the way our body can absorb vitamin B12 from our diet. This is the story of vitamin B12. Our special guest: Our special guest is Professor Ken Sikaris who is a chemical pathologist and Director of Chemical Pathology at Dorevitch Pathology.See omnystudio.com/listener for privacy information.
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Episode 85: Lung Cancer Screening | Search For The 30 Pack-Years
One of the most difficult cancers to detect early has been lung cancer. Patients often present with advanced disease that and can often be fatal. In April 2025, a new National Lung Cancer Screening program has been rolled out in Australia to detect asymptomatic patients with a significant smoking history (30 Pack-Year). Suitable patients are eligible for a free low-dose CT (computer tomography) scan on their lungs to identify any potential lesions suspicious for cancer. This is the story of lung cancer screening. Our special guests: A/Professor Nicole Rankin is Head of the Evaluation and Implementation Science Unit in Melbourne School of Population and Global Health (University of Melbourne) and led the team that developed the Australian National Lung Cancer Screening Program Guidelines. Dr Julie Teague is an Anatomical Pathologist with an interest in thoracic and gastrointestinal pathology.See omnystudio.com/listener for privacy information.
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Episode 84: Prostate Cancer | Donald Gleason’s Legacy
In 1966, the Chief of Urology asked the Chief of Pathology at the Minneapolis VA Hospital to develop a system to communicate the results of prostate cancer to researchers. The Chief of Pathology was Donald Gleason and he developed a system that would revolutionise our understanding of prostate cancer. Today, every prostate cancer worldwide is classified using the Gleason score, named after Donald Gleason. Prostate cancer is one of the most common cancers worldwide and accounts for 15% of all male cancers. Its incidence of prostate cancer is estimated to double by 2040. This is the story of prostate cancer. Our special guests: Professor Fiona Maclean is a Clinical Professor, Anatomical Pathologist, author, past President of the Australasian Division of the International Academy of Pathology (IAP), and advisor in Pathology Artificial Intelligence. Dr Joanna Olphert is a urologist and robotic surgeon involved in genitourinary reconstructive surgery, robotic uro-oncology, and open complex peritoneal surgery. Dr Carole Harris is a medical oncologist, senior lecturer, and senior research fellow.See omnystudio.com/listener for privacy information.
In 1951, Australian anthropologists reported on a unique neurodegenerative disease from Papua New Guinea. The natives called it ‘Kuru’ which meant to tremble or to be afraid and it certainly struck fear into those who saw it. Through amazing investigative work and serendipity, a veterinary pathologist in the United States saw the histology of a Kuru from the brain and noted it looked a lot like ‘Scrapie’ (a neurodegenerative disease in sheep) and the link was made. It would not be until 1980s that the causative agent for these diseases was identified: Prion’s. And then in the 1990s, cows in the United Kingdom began showing symptoms… This is the story of Prion diseaseSupport the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.
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Episode 13: Japanese Encephalitis Virus (JEV) | Encephalitis epidemics
In 1924, a previously well 20 year old woman presented to hospital with a headache and general fatigue. Her condition rapidly deteriorated and she died in 6 days. Over 6000 cases occurred within 1924. The search was on to find the cause. Fortunately, in 1935, a breakthrough occurred. We know the virus today as the Japanese Encephalitis Virus. The vast majority of people who become infected with JEV are either oblivious (asymptomatic) or only have mild non-specific viral symptoms (ie. fever). However, those who are very unwell and require hospitalisation have significant risks of morbidity and mortality. In 2022, cases of JEV have been identified in Queensland, New South Wales, Victoria and South Australia. This is the first time cases have been recorded this far south. We know that JEV is endemic in at least 24 countries around Asia. Is Australia going to become the 25th? This is the story of Japanese Encephalitis Virus.Support the show: https://theadelaideshow.com.au/listen-or-download-the-podcast/adelaide-in-crowd/See omnystudio.com/listener for privacy information.See omnystudio.com/listener for privacy information.
Welcome to the This Medical Life podcast. Our mission is to share stories about the triumphs and tragedies of diseases and illnesses from ancient times up until what we know today. It is about those scientific and medical minds who came before us and how, every single day, we stand on the shoulders of giants. This is a podcast about the stories of medicine.
Hosted by Dr. Travis Brown and Steve Davis, our target audience is General Practitioners, medical students, and other health professionals. We hope to educate, inspire and celebrate those who choose to care for others in their profession. From experience, we know that our audience extends beyond these fields and would like to welcome anyone to listen. The stories of those who came before us are nothing short of remarkable and we hope you enjoy them as much as we do.
Production by Tim Whiffen
Design by Tom Buzz
South Africa