Extend Podcast with Darshan Shah, MD

Have you ever wondered if memory loss or cognitive decline is inevitable as we age? What if I told you it’s not—and that, with the right strategies, you can even reverse early signs of neurodegeneration? In this episode of Extend with Dr. Darshan Shah, I sit down with my friend and esteemed colleague, Dr. Dale Bredesen, a pioneer in brain health and the author of The End of Alzheimer’s. Dr. Bredesen has completely changed the way I see cognitive decline, and today, we’re sharing how cutting-edge science is making Alzheimer’s a preventable—and even reversible—condition. Together, we explore some of the most exciting advancements in brain health, from blood tests that predict neurodegenerative diseases years before symptoms appear to the role of inflammation, toxins, and even oral health in driving cognitive decline. We also dive into the power of personalized medicine, showing how addressing root causes can lead to profound recovery. You’ll hear inspiring stories of patients who were told they had no hope, only to reclaim their lives through Dr. Bredesen’s groundbreaking protocols. If you want to optimize your longevity, this is an episode you won’t want to miss. We Also Discuss: (00:02) Advances in Brain Health (07:58) Neural Systems and Disease Progression (13:09) Inflammation, Immune Response, and Neurodegeneration (28:07) Brain Health Through Sleep and Toxins (37:17) Early Detection and Prevention Strategies (48:38) Brain Health Advancements and Technologies (57:39) Aging and Brain Health Optimization (01:05:13) Embracing Life After Retirement Graduation (01:14:12) New Books in Alzheimer's Treatment   Thank You to Our Sponsors: Timeline: If you are looking for a boost in a cellular level, Timeline is the secret to unlocking your mitochondria's whole potential. Go to: https://www.timeline.com/  TruNiagen: Whether you are looking to stay sharp, feel more energized or simple age better, go to https://www.truniagen.com/  IFIT: If you are looking to elevate your home gym fitness experience with the best in fitness tech, choose IFIT. Go to https://www.ifit.com/ Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/ Learn more about Dr. Dale Bredesen   Instagram: drdalebredesenPreCODE and ReCODE: https://www.apollohealthco.com/solutions/   

Are you trapped in the cycle of endless dieting and calorie counting? For years, we've been told that weight loss is as simple as “calories in, calories out,” but if that’s true, why do so many of us still struggle? What if the problem isn’t just the numbers, but how we think about them? In this episode of theExtend podcast, I take a closer look at why the traditional approach to calorie control fails—and what you can do instead. From the science behind metabolic rate to the surprising impact of ultra-processed foods on your hunger and hormones, I’m going to break down the three key levers for weight management: calorie restriction, dietary restriction, and time-restricted eating. I also reveal why most diets are destined to fail and how small, sustainable changes can transform not just your weight, but your overall health and energy levels. If you’re ready to break free from ineffective methods and embrace a smarter approach, this episode is packed with insights you don’t want to miss.  Tune in to discover how you can not just lose weight but feel better in your own skin. We Also Discuss:   (01:51-02:58) Not All Calories Are Created Equal (03:31-04:20) The Japanese Secret to Mindful Eating (06:50-07:28) Where Your Calories Go: Total Energy Expenditure (08:58-09:38) Why Diets Fail 90% of the Time (10:22-11:37) Time-Restricted Eating: Is Fasting for You?   Thank You to Our Sponsors: TruNiagen: Whether you are looking to stay sharp, feel more energized or simple age better, go to https://www.truniagen.com/   Learn more about Dr. Shah:   Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/

Ever find yourself putting in the time at the gym, only to feel like you’re barely moving the needle? Or notice that staying in shape seems to get tougher every year? Here’s the thing: muscle health is the backbone of your metabolism, strength, and long-term vitality, but it’s often the missing link in most people’s routines. In this episode, I’m thrilled to sit down with JJ Virgin. Together, we dive into why muscle matters for more than just strength, how to use high-intensity interval training to hit your fitness goals faster, and practical hacks for optimizing your protein intake—no more wasting time on ineffective routines. JJ Virgin is a leading voice in health and fitness, a best-selling author, and a nutrition and exercise expert. With over three decades of experience, she is dedicated to helping people maximize longevity and metabolic health through science-based, personalized strategies. As a pioneer in the field of powerful aging and fitness for women, JJ blends science and practical advice to promote a strong, active approach to aging. ➡️ If you're ready to understand how to work with your body’s natural strengths instead of fighting against it, this is the episode for you. Listen to the full episode of Extended with Dr. Shah for more insights! We Also Discuss: (00:00) Expert Insights on Fitness and Nutrition (04:07) Strength Training for Longevity (28:45) Building Muscle and Custom Training (49:18) Travel-Friendly Workout Tips (01:01:44) Nutrition Strategies for Muscle Growth (01:36:26) Hormone Health in Menopause Thank You to Our Sponsors: Timeline: If you are looking for a boost in a cellular level, Timeline is the secret to unlocking your mitochondria's whole potential. Go to: https://www.timeline.com/  TruNiagen: Whether you are looking to stay sharp, feel more energized or simple age better, go to https://www.truniagen.com/  IFIT: If you are looking to elevate your home gym fitness experience with the best in fitness tech, choose IFIT. Go to https://www.ifit.com/ Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/ Learn more about JJ. Virgin: Website: https://jjvirgin.com/Instagram: @jj.virgin

Are you part of the 88% of people who are metabolically unhealthy—and don’t even know it? Do you know what metabolic health really means? Or why is it the root cause of nearly every chronic disease? In this episode of Extend, I’m diving deep into the critical world of metabolic health—how it works, why it matters, and what you can do today to optimize it. With only 12% of Americans metabolically healthy, it’s time to take charge. I’ll break down the science of mitochondria, share the key biomarkers you need to track, and show you how tools like continuous glucose monitors (CGMs) can transform your health. Plus, I’ll give you practical, everyday tips to flatten glucose spikes, stabilize your energy, and protect yourself from chronic disease. This episode isn’t just about theory—it’s about empowering you with tools and tips to optimize your metabolic health and live longer, healthier, and more energized. I Also Discuss:   (00:03) Understanding Metabolic Health and Disease (02:05) The Role of Mitochondria in Energy and Metabolism (05:56) Key Biomarkers for Tracking Metabolic Health (09:35) How Continuous Glucose Monitors Can Transform Your Health (13:40) Mastering Metabolic Health and Vitality   Learn more about Dr. Shah: Website: https://www.drshah.com/ Clinic: https://www.next-health.com/ Instagram: https://www.instagram.com/darshanshahmd/