The Human Upgrade with Dave Asprey

• Longevity Scientists Discover a Breakthrough Peptide That Reverses Hair Loss | Carolina Reis Oliveira : 1269

  If your hair is thinning, shedding, or simply not what it used to be—and nothing seems to work—this episode is for you. Because what if the story you’ve been told about balding… is wrong? For decades, hair loss has felt like fate: genetic, inevitable, untouchable. But science is catching up to something deeper—something root-level. What if the real culprit behind age-related hair loss is cellular dysfunction? And what if we could change that? In this episode, Dave Asprey uncovers the cellular biology of hair thinning with longevity researcher Carolina Reis Oliveira. You’ll learn how senescent cells (aka zombie cells) hijack your scalp, disrupt follicle function, and silently accelerate hair loss—and how a breakthrough peptide might stop it cold. Carolina reveals brand-new clinical research on OS-01, a molecule shown to increase hair density by 40% in just 6 months. But this isn’t a product pitch—it’s a paradigm shift. Together, they explore the hidden drivers of hair aging, from hormone shifts and stress cascades to microbiome imbalances and inflammation, plus the real science behind what can actually regrow hair. What You’ll Learn in This Episode: • How “zombie cells” (senescent cells) sabotage your hair from the inside out • The science behind the OS-01 peptide and how it reverses visible hair thinning • Why thinning hair isn’t just genetic—and what else is driving it • How stress, hormones, and aging collide to trigger follicle dysfunction • What your scalp microbiome has to do with regrowth and hair density • How to stack red light, peptides, and topicals for real, measurable results ***Visit oneskin.co/DAVE and use code DAVE for and additional 15% off.*** Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • OneSkin Instagram – https://www.instagram.com/oneskin.co/ • OneSkin Website: https://www.oneskin.co/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 — Trailer • 01:52 — Intro • 02:59 — Is Aging Optional for Your Scalp? • 04:03 — Understanding Scalp and Hair Aging • 05:06 — The Role of Senescent Cells in Hair Loss • 07:25 — Hormonal Influences on Hair Health • 16:10 — Peptide Solutions for Hair Thinning • 18:05 — Clinical Studies and Results • 20:29 — Future of Hair Loss Treatments • 30:16 — Nutritional and Lifestyle Factors • 36:40 — Addressing Senescent Cells and Hair Growth • 37:29 — Minoxidil: Oral vs. Topical Use • 39:32 — Personal Experience with Hair Products • 40:25 — Combining Therapies for Hair Growth • 46:06 — Nutritional Factors in Hair Health • 52:20 — Sun Exposure and Hair Health • 56:40 — Coffee and Hair Growth • 01:00:01 — Launching the New Hair Product See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  59:55
• Identity Hacker: How to Completely Change Your Personality at ANY Age | Olga Khazan : 1268

  What if you could rewrite the code of your personality—on command? Not just cope with anxiety, overthinking, or social exhaustion… but delete the traits holding you back and install better ones? This episode challenges everything you’ve been told about identity. Dave dives deep into the science of personality change to reveal why your habits, moods, triggers, and even sense of self aren’t fixed—they’re fluid. And more importantly: they’re up for grabs. Joining him is award-winning journalist from The Atlantic, Olga Khazan, author of Me, But Better, who spent years hacking her own mind—transforming high neuroticism, social avoidance, and chronic self-criticism into calm, confidence, and connection. Her personal experiment in identity rewiring became a roadmap for anyone who wants to feel different… and live differently. You’ll uncover the hidden mechanisms behind neuroticism, reactivity, and emotional spirals—and how to override them with real-time upgrades. What You’ll Learn in This Episode: • Why your personality is a program—and how to recode it • What daily behaviors scientifically rewire anxiety, anger, and reactivity • The surprising link between identity, inflammation, and your gut • Why gratitude isn’t soft—it’s neurological jiu-jitsu • How to know if it’s your biology or your story running the show • Whether pills, psychedelics, or sleep do more to shift who you are • What to do when your inner critic won’t shut up • And how to stop being the person you never meant to become SPONSORS -LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE. -Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. Resources: • Olga’s New Book – Me, But Better: https://www.amazon.com/Me-But-Better-Science-Personality/dp/1668012545 • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Olga's Instagram – https://www.instagram.com/olganator/?hl=en • Olga’s Website: https://olgakhazan.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 0:00 — Trailer • 1:52 — Intro • 2:16 — Personality Changes and Neuroticism • 5:38 — Postpartum Personality Shifts • 10:21 — Gratitude and Cultural Beliefs • 18:13 — Anger Management and Empathy • 32:58 — Personality Traits and Boundaries • 35:46 — The Importance of Strong Boundaries • 36:07 — Personality Change as Self-Improvement • 37:22 — The Role of Medication in Personality Change • 39:18 — Brain-Body Connection and Mental Health • 43:26 — Impact of Sleep and Nutrition on Personality • 44:23 — Nicotine and Other Substances • 45:41 — Therapy and Personality Change • 46:43 — Changing Personality Through Behavior • 1:01:25 — The Role of Relationships in Personality Development • 1:04:49 — Challenges and Methods in Personality Change • 1:08:38 — The Power of Improv in Personality Change • 1:10:17 — Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  1:06:13
• Psychedelic States On-Demand (No Substances Needed) | Dr. Patrick Porter : 1267

  Your brain isn’t broken—it’s underpowered. Energy crashes, poor sleep, brain fog, and emotional reactivity don’t just happen. You’re running on low voltage, and your mind pays the price. In this episode, Dave sits down with Dr. Patrick Porter, founder of BrainTap, to reveal how to reprogram your brain using light, sound, and guided visualization—no substances, no side effects, no BS. Dr. Porter breaks down how to activate gamma brainwaves, repair trauma loops, access psychedelic-like states, and boost cognitive performance by 19% in just six weeks. You’ll learn why most brains burn out decades too soon—and how to charge yours back up. What You’ll Learn in This Episode: • How to flood your brain with energy and wake it up • The light and sound protocol that mimics psychedelics—safely • What gamma brainwaves unlock—and how to generate them on demand • Why your default mode network traps you in stress and distraction • The BrainTap protocol that improved cognition by 19% in 6 weeks • A real-life transformation story that rewrote one woman’s fate • The link between sleep, trauma, brain states, and performance • How to build a brain that performs like it’s decades younger This episode gives you a playbook to reclaim your focus, deepen your rest, and experience the full range of human consciousness—without touching a drug. Turn your brain on. Then turn it up. SPONSORS -STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order. -BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. Resources: • Biohacking Conference 2025 (May 28th-30th in Austin): https://biohackingconference.com/2025 (use code BRAINTAP to save 30% on General Admission and Virtual Tickets)• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • BrainTap Instagram: https://www.instagram.com/braintaptech/?hl=en • BrainTap Website: https://braintap.com/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Trailer • 00:35 – Intro • 00:50 – Meet Dr. Patrick K. Porter and BrainTap • 01:28 – The Science Behind Light and Sound Therapy • 03:38 – Quantum Biology and Frequency Medicine • 04:32 – Enhancing Cognition with Sound and Light • 06:19 – Biohacking Conference Highlights • 08:07 – Transformative Stories and BrainTap Benefits • 17:54 – The Role of Gamma Waves and Psychedelics • 26:55 – Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  29:07
• Why Gen Z Can’t Handle the Real World (and How We Can Help Them) | Jennifer Cohen : 1266

  You think you’re helping your kid. You clear the path. You smooth the bumps. You make sure they never feel too sad, too bored, too uncomfortable. It feels like love. But what if it’s making them weak? In this episode, Dave Asprey sits down with bestselling author, TED speaker, and resilience expert Jennifer Cohen to reveal how today’s parenting norms are quietly producing the most anxious, dependent, and emotionally fragile generation in history—Gen Z. Whether you’re raising kids, managing young employees, or trying to understand the next generation—you’ll walk away from this episode with a new lens on resilience, responsibility, and real-world readiness. What You’ll Learn in This Episode: • Why Gen Z struggles with anxiety, confidence, and failure • How smartphones, safe spaces, and overparenting weaken resilience • The science behind boredom, chores, and grit-building discomfort • Why participation trophies are doing real psychological harm • The bold parenting shifts that build strong, adaptable adults • How to model strength—even when it’s unpopular • The simple framework to raise kids who can thrive, not just survive If you want to raise strong kids—or work with a generation that’s struggling—this episode is a must-listen. It’s not just about parenting. It’s about the future. And it starts with getting uncomfortable. SPONSORS -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -Qualia | Go to https://www.qualialife.com/dave15 to get an additional 15% off subscriptions. Resources: • A Day of Biohacking and Consciousness Even (4/12): https://daveasprey.com/biohacking-and-consciousness/ • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Jennifer’s Instagram: https://www.instagram.com/therealjencohen/ • Jennifer’s Podcast: https://www.youtube.com/channel/UCBuPgI8lXTmy5T0D_EDMnVg • Jennifer’s Website: https://www.jennifercohen.com/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Trailer • 01:59 – Intro • 03:38 – The Shift in Parenting Styles • 07:04 – The Role of Technology and Social Media • 10:59 – The Importance of Failure and Resilience • 13:38 – Practical Parenting Tips and Challenges • 24:06 – The Value of Chores and Responsibility • 26:24 – Balancing Luxury and Adversity in Parenting • 27:01 – Teaching Kids to Embrace Failure • 28:00 – The 10% Target: Encouraging Persistence • 29:35 – The Importance of Boredom and Creativity • 30:58 – Role Modeling Healthy Habits • 31:43 – Kids’ Reactions to Fast Food • 32:49 – Extreme Parenting: Biohacking and Kids • 36:30 – Rejection Therapy and Boldness • 42:42 – Praising Effort Over Intelligence • 45:32 – Challenges of Being Attractive and Intelligent • 49:31 – Instilling Self-Esteem in Children • 50:13 – Conclusion and Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  51:24
• The Dirty Secret Behind Ozempic: How It Wrecks Your Gut (Here’s How to Fix It) | Hannah Kleinfeld : 1265

  For decades, gut health was reduced to yogurt commercials and vague promises from probiotics that barely worked. But what if we’ve been targeting the wrong bugs, using the wrong delivery, and ignoring the true source of chronic inflammation and accelerated aging? In this thought-provoking episode, Dave sits down with Hannah Kleinfeld, a leader in microbiome innovation, to expose why most probiotics fail—and how one company’s scientifically validated approach could redefine your gut, brain, immune system, and even your metabolism. You’ll learn how dysbiosis may be wrecking your brain without you knowing it, why your probiotic likely died in your stomach acid, and the secret to rebooting your microbiome after antibiotics, GLP-1 drugs, or years of toxic exposure. This isn’t just about digestion—your gut controls your cravings, energy, sleep, mood, and aging trajectory. So what’s the one upgrade that can actually reset your gut… for good? What You’ll Learn in This Episode: • Why your gut—not your brain—is making most of your decisions • How 93% of probiotics on the market fail before they reach your intestines • The “AB 10” protocol that rebuilds your gut after antibiotics or SIBO • What GLP-1 weight-loss drugs are doing to your microbiome (and how to stop it) • The shocking gut–brain–heart axis connection you’ve never heard of • Why inflammation, brain fog, and mood swings may start with leaky gut • Which probiotic strains are clinically proven to improve cognition and mood • What to do if you want to eat gluten again—or survive American wheat • How a fermented papaya concentrate could replace your acid reflux meds • Why optimizing your gut could extend your lifespan by 40% ***Get 20% off your next purchase by going to https://omnibioticlife.com/pages/dave-asprey/ or omnibioticlife.com/dave*** SPONSORS -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • OMNi-BiOTiC's Instagram – https://www.instagram.com/fatty15/ • OMNi-BiOTiC's Website: https://omnibioticlife.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Trailer • 03:15 – Intro • 05:05 – Probiotics, Prebiotics, and Postbiotics Explained • 08:21 – The Importance of Delivery Mechanisms • 17:36 – Addressing SIBO and Gut Health Protocols • 31:55 – The Impact of GLP-1 Drugs on Gut Health • 39:26 – The Role of Gut Bacteria in Hunger and Fasting • 40:01 – Painkillers and Gut Health: A Personal Experience • 40:51 – The Dangers of Proton Pump Inhibitors • 42:00 – The Importance of Stomach Acid • 44:55 – Probiotics for Chronic Conditions • 48:38 – The Impact of Glyphosate on Gut Health • 57:04 – Alcohol and Gut Bacteria • 01:02:01 – New Solutions for Acid Reflux • 01:07:57 – The Future of Gut Health and Longevity • 01:11:33 – Conclusion and Special Offer See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  1:13:03

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