Medscape InDiscussion: Bipolar Disorder

• The Future of Bipolar Disorder Treatment With Psychedelics and Neuromodulation

  Drs Trisha Suppes and Scott T. Aaronson discuss rapid-acting therapies for bipolar disorder and the future of psychedelics and neuromodulation in its treatment. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999802. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Bipolar Disorder https://emedicine.medscape.com/article/286342-overview The Effects of Vagus Nerve Stimulation on the Course and Outcomes of Patients With Bipolar Disorder in a Treatment-Resistant Depressive Episode: A 5-Year Prospective Registry https://pubmed.ncbi.nlm.nih.gov/32358769/ A 5-Year Observational Study of Patients With Treatment-Resistant Depression Treated With Vagus Nerve Stimulation or Treatment as Usual: Comparison of Response, Remission, and Suicidality https://pubmed.ncbi.nlm.nih.gov/28359201/ c-Fos and pERK, Which Is a Better Marker for Neuronal Activation and Central Sensitization After Noxious Stimulation and Tissue Injury? https://pubmed.ncbi.nlm.nih.gov/19898681/ Repetitive Transcranial Magnetic Stimulation in the Treatment of Bipolar Disorder https://pubmed.ncbi.nlm.nih.gov/33282175/ Efficacy of Active vs Sham Intermittent Theta Burst Transcranial Magnetic Stimulation for Patients With Bipolar Depression: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/33710288/ A Retrospective Analysis of Bipolar Depression Treated With Transcranial Magnetic Stimulation https://pubmed.ncbi.nlm.nih.gov/33169946/ When to Hold and When to Fold: Early Prediction of Nonresponse to Transcranial Magnetic Stimulation in Major Depressive Disorder https://pubmed.ncbi.nlm.nih.gov/38458381/ Dosing Transcranial Magnetic Stimulation in Major Depressive Disorder: Relations Between Number of Treatment Sessions and Effectiveness in a Large Patient Registry https://pubmed.ncbi.nlm.nih.gov/37827360/ Sequenced Treatment Alternatives to Relieve Depression (STAR*D): Rationale and Design https://pubmed.ncbi.nlm.nih.gov/15061154/ Single-Dose Synthetic Psilocybin With Psychotherapy for Treatment-Resistant Bipolar Type II Major Depressive Episodes: A Nonrandomized Controlled Trial https://pubmed.ncbi.nlm.nih.gov/38055270/

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• Managing the Interplay of Bipolar Disorder and Substance Use Disorders

  Drs Trisha Suppes and Michael J. Ostacher discuss treatments for patients with bipolar disorder who also have substance abuse disorder. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999801. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Bipolar Disorder https://emedicine.medscape.com/article/286342-overview Management of Comorbid Bipolar Disorder and Substance Use Disorders https://pubmed.ncbi.nlm.nih.gov/28301219/

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• The Importance of Managing Circadian Rhythms in Patients With Bipolar Disorder

  Drs Trisha Suppes and Holly A. Swartz discuss the impact of circadian and social rhythms on patients with bipolar disorder, as well as the power of psychotherapy. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999800. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Bipolar Disorder https://emedicine.medscape.com/article/286342-overview Circadian Rhythm in Bipolar Disorder: A Review of the Literature https://pubmed.ncbi.nlm.nih.gov/29869403/ Efficacy of the Interpersonal and Social Rhythm Therapy (IPSRT) in Patients With Bipolar Disorder: Results From a Real-World, Controlled Trial https://pubmed.ncbi.nlm.nih.gov/32165907/ Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 Guidelines for the Management of Patients With Bipolar Disorder https://pubmed.ncbi.nlm.nih.gov/29536616/ Psychotherapy Alone and Combined With Medication as Treatments for Bipolar II Depression: A Randomized Controlled Trial https://pubmed.ncbi.nlm.nih.gov/28703949/ 26th Annual Conference of the International Society for Bipolar Disorders September 29 – October 1, 2024 Reykjavik, Iceland https://www.isbd.org/Program Nutrition and Bipolar Disorder: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/35608150/ Single-Dose Synthetic Psilocybin With Psychotherapy for Treatment-Resistant Bipolar Type II Major Depressive Episodes: A Nonrandomized Controlled Trial https://pubmed.ncbi.nlm.nih.gov/38055270/ Brain Stimulation Treatment for Bipolar Disorder https://pubmed.ncbi.nlm.nih.gov/36515461/

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• What Are the Latest Advances in Screening Tools and Treatments of Bipolar Disorder?

  Drs Trisha Suppes and Roger S. McIntyre discuss screening tools for bipolar disorder, treatment advances, and the impact of clues such as inflammation on this diagnosis. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/999799). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Bipolar Disorder https://emedicine.medscape.com/article/286342-overview Crosstalk Between Existential Phenomenological Psychotherapy and Neurological Sciences in Mood and Anxiety Disorders https://pubmed.ncbi.nlm.nih.gov/33801765/ Psychedelics in the Treatment of Unipolar and Bipolar Depression https://pubmed.ncbi.nlm.nih.gov/35788817/ Inflammatory Signaling Mechanisms in Bipolar Disorder https://pubmed.ncbi.nlm.nih.gov/34112182/ The Rapid Mood Screener (RMS): A Novel and Pragmatic Screener for Bipolar I Disorder https://pubmed.ncbi.nlm.nih.gov/33300813/ Establishment of Diagnostic Validity in Psychiatric Illness: Its Application to Schizophrenia https://pubmed.ncbi.nlm.nih.gov/5409569/ Rapid Mood Screener https://www.rapidmoodscreener.com/

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• Exploring Cognition in Patients With Bipolar Disorder

  Drs Trisha Suppes and Allan Young explore the intricate landscape of cognitive challenges in bipolar disorder. Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/999798). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Bipolar Disorder https://emedicine.medscape.com/article/286342-overview Montreal Cognitive Assessment for the Detection of Dementia https://pubmed.ncbi.nlm.nih.gov/34255351/ Mini-Mental State Examination (MMSE) for the Early Detection of Dementia in People With Mild Cognitive Impairment (MCI) https://pubmed.ncbi.nlm.nih.gov/34313331/ Domains of Cognition and Their Assessment
https://pubmed.ncbi.nlm.nih.gov/31749647/ Shifting Between Mental Sets: An Individual Differences Approach to Commonalities and Differences of Task Switching Components https://pubmed.ncbi.nlm.nih.gov/28594189/ Neurocognitive Impairment in Euthymic Patients With Bipolar Affective Disorder https://pubmed.ncbi.nlm.nih.gov/15630121/ The Dunedin Multidisciplinary Health and Development Study: Overview of the First 40 Years, With an Eye to the Future https://pubmed.ncbi.nlm.nih.gov/25835958/ Exploring the Genetics of Lithium Response in Bipolar Disorders https://pubmed.ncbi.nlm.nih.gov/38077040/ Advances Toward Precision Medicine for Bipolar Disorder: Mechanisms & Molecules https://pubmed.ncbi.nlm.nih.gov/32636474/ Cognitive Remediation Therapy for Patients With Bipolar Disorder: A Randomised Proof-of-Concept Trial https://pubmed.ncbi.nlm.nih.gov/32583630/ Randomised Controlled Cognition Trials in Remitted Patients With Mood Disorders Published Between 2015 and 2021: A Systematic Review by the International Society for Bipolar Disorders Targeting Cognition Task Force https://pubmed.ncbi.nlm.nih.gov/35174594/ The Cognitive Remediation in Bipolar (CRiB) Pilot Study: Study Protocol for a Randomised Controlled Trial https://pubmed.ncbi.nlm.nih.gov/27472964/ Cognitive Remediation in Bipolar (CRiB2): Study Protocol for a Randomised Controlled Trial Assessing Efficacy and Mechanisms of Cognitive Remediation Therapy Compared to Treatment as Usual https://pubmed.ncbi.nlm.nih.gov/37968619/ Transdiagnostic Approaches to Mental Health Problems: Current Status and Future Directions https://pubmed.ncbi.nlm.nih.gov/32068421/ Psilocybin: From Serendipity to Credibility? https://pubmed.ncbi.nlm.nih.gov/33967860/

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