Over 40 Fitness Hacks

• 592: Dr. Bill Adrews - Can We Slow — or Reverse — Aging? Telomeres, Telomerase & Longevity

  Can We Slow — or Reverse — Aging? Telomeres, Telomerase & LongevityClick On My Website Below To Schedule A Free 15 Min Zoom Call:www.Over40FitnessHacks.comOver 40 Fitness Hacks SKOOL Group!Get Your Whoop4.0 Here!Dr. Bill Andrews - Telomere Health & Longevitywww.thegoodinside.com - Touchstone Essentials supplements.Email: [email protected] snapshot: Dr. Bill Andrews—biotech veteran and founder of Sierra Sciences—has spent his career chasing a practical way to slow (and ultimately reverse) human aging. Inspired by a childhood mission from his dad to “find a cure for aging,” he helped lead the discovery of human telomerase at Geron in the 1990s.Why we age: Aging isn’t great for the individual, but it benefits the species (greater diversity and adaptability). Mechanistically, “wear and tear” accumulates—and our ability to replace damaged cells is capped by the Hayflick limit.Ride tickets analogy: Every time a cell divides it “uses a ticket.” Those tickets are telomeres (the DNA caps on chromosomes). When tickets run out, cells enter senescence and die.Telomerase: In reproductive cells, the enzyme telomerase adds tickets back, keeping telomeres long—why children aren’t born “older” than their parents. In most other cells, the telomerase gene is repressed.His team screens plant extracts to dislodge repressor proteins on the telomerase gene “dimmer switch,” aiming to partially turn it back on.Partial activation ≠ reversal, but it can slow telomere shortening (slowing aging). He believes stronger activators that can win the “tug-of-war” and lengthen telomeres meaningfully could arrive in ~1–3 years if progress continues.Andrews licensed several top nutraceutical fractions that, in his assays, induce telomerase expression modestly and include antioxidants/anti-inflammatories to reduce accelerated shortening.Notable: a turmeric fraction without curcumin (their strongest inducer), plus pomegranate, skullcap root, “gal nut,” and others. No “proprietary blend” label—ingredients are listed individually.He stresses Telo-Vital slows aging; occasional anecdotal reversals (hair/vision/sleep) may occur when tissues have critically short telomeres that are easier to re-lengthen.Do something daily. Consistent, enjoyable endurance-style movement can lower inflammation/oxidative stress; stop before it stops being fun.What can accelerate shortening: frequent senolytics (create gaps → more cell division), high alcohol (liver turnover), growth-hormone/“immune boosters” that drive cell division, and chronic inflammation/oxidative stress.What helps slow acceleration: anti-inflammatory/antioxidant strategies, better glucose control (he mentions a product that “converts sugar to fiber”), mitochondrial support like urolithin A and NAD/Niagen (NR).Product: Telo-Vital (Touchstone Essentials) — site: thegoodinside.comDr. Andrews (science questions): [email protected] can share recommended YouTube talks on telomeres/telomerase and aging.Bottom line: Telomere shortening is a central, measurable driver of aging. Today’s tools may slow that process; Andrews is racing to make meaningful lengthening practical next.If you're interested in online personal training or being a guest on my podcast, "Over 40 Fitness Hacks," you can reach me at [email protected] or visit my website at:www.Over40FitnessHacks.comAdditionally, check out my Yelp reviews for my local business, Evolve Gym in Huntington Beach, at https://bit.ly/3GCKRzV

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• 591: Brad Williams - EPOC Explained: The Afterburn Effect That Boosts Metabolism and Mitochondria

  EPOC Explained: The Afterburn Effect That Boosts Metabolism and MitochondriaClick On My Website Below To Schedule A Free 15 Min Zoom Call:www.Over40FitnessHacks.comOver 40 Fitness Hacks SKOOL Group!Get Your Whoop4.0 Here!Episode Summary: Boosting Energy and Mitochondria Efficiency with HIT and EPOCIn this episode of Over 40 Fitness Hacks, host Brad Williams dives deep into how High-Intensity Training (HIT) and Excess Post-Exercise Oxygen Consumption (EPOC) can reignite energy levels, boost metabolism, and increase mitochondrial efficiency—especially important for those of us over 40.After recovering from hernia surgery, Brad shares his experience noticing a drop in calorie burn and energy output on his Whoop tracker. He explains how this decline connected to reduced mitochondrial activity from skipping HIT sessions. Turning to ChatGPT for insights, Brad explores how HIT stimulates mitochondrial biogenesis—the process of creating new mitochondria—by pushing the body to oxygen debt and triggering powerful recovery processes afterward.He breaks down the “afterburn effect” (EPOC), explaining how intense bursts of effort force the body to consume extra oxygen post-workout to restore balance, repair tissue, and boost metabolism for up to 36 hours. Brad also compares Zone 2 cardio (steady-state fat burning) with Zone 5 HIT (maximum heart rate, short bursts) and why both are crucial for longevity and efficiency.Listeners will learn:How HIT drives more calorie burn and mitochondrial density than slower workouts.The science behind EPOC and why it’s a key to sustained fat loss.How to structure HIT for maximum efficiency (e.g., 30 seconds all-out, 90 seconds rest).Why adding weights or masks during HIT can actually reduce heart rate and efficiency.The importance of balancing intensity with recovery to avoid cortisol spikes and fatigue.Brad wraps up by sharing his plan to reintroduce weekly HIT sessions—short, bodyweight-based, and focused purely on speed and heart rate—to reignite energy and optimize his mitochondria naturally before turning back to supplements.🎧 Key takeaway: You don’t need long workouts—just efficient, intense bursts that supercharge your metabolism and rebuild your body’s cellular engines.If you're interested in online personal training or being a guest on my podcast, "Over 40 Fitness Hacks," you can reach me at [email protected] or visit my website at:www.Over40FitnessHacks.comAdditionally, check out my Yelp reviews for my local business, Evolve Gym in Huntington Beach, at https://bit.ly/3GCKRzV

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• 590: Brad Pitzele - Rebuilding Health with Oxygen: The Science Behind EWOT

  Rebuilding Health with Oxygen: The Science Behind EWOTClick On My Website Below To Schedule A Free 15 Min Zoom Call:www.Over40FitnessHacks.comOver 40 Fitness Hacks SKOOL Group!Get Your Whoop4.0 Here!Brad Pitzele - EWOT (Exercise While On Oxygen Therapy)www.onethousandroads.comYouTube: @OneThousandRoadsHQIn this episode of Over 40 Fitness Hacks, host Brad Williams sits down with Brad Pitzele, founder of One Thousand Roads, to explore Exercise with Oxygen Therapy (EWOT)—a powerful biohacking modality that combines cardio exercise with oxygen enrichment to boost health, performance, and longevity.Brad shares his personal battle with autoimmune arthritis and Lyme disease, a journey that began over a decade ago. After years of medication cycles, painful symptoms, and even a bout with melanoma, he sought alternative healing paths. Conventional treatments offered no long-term relief, leading him to research deeper into root causes and natural recovery methods.When a doctor suggested trying hyperbaric oxygen therapy or EWOT, Pitzele balked at the cost and accessibility of hyperbaric chambers. Instead, he built his own EWOT system, experienced dramatic recovery over several months, and eventually founded One Thousand Roads in 2018 to make the technology affordable and accessible.EWOT involves 15 minutes of moderate cardiovascular exercise while breathing near-pure oxygen through a mask connected to a large oxygen reservoir. Key points:Uses oxygen concentrators to fill a 1,000-liter reservoir.Enables oxygen delivery far beyond what standard machines can supply.Can be used with any stationary cardio equipment (bike, treadmill, rebounder, etc.).Requires only standard electrical outlets and minimal setup space.Pitzele explains that as we age, “inflammaging” causes microscopic capillaries to constrict, restricting oxygen delivery and forcing cells into low-energy, anaerobic states. EWOT reverses this by:Reoxygenating plasma to reach starved tissues.Reducing inflammation and restoring blood flow.Reactivating mitochondria (cellular powerhouses) and promoting new mitochondrial growth.Boosting VO₂ max, endurance, and recovery.Enhancing detoxification, as oxygen helps flush toxins and lactic acid.Supporting fat burning and overall energy production.Unlike hyperbaric oxygen, which relies on external pressure, EWOT uses exercise-driven oxygen demand for faster, more efficient absorption.If you're interested in online personal training or being a guest on my podcast, "Over 40 Fitness Hacks," you can reach me at [email protected] or visit my website at:www.Over40FitnessHacks.comAdditionally, check out my Yelp reviews for my local business, Evolve Gym in Huntington Beach, at https://bit.ly/3GCKRzV

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• 589: Dr. Khoshal Latifzai - Beyond the Calcium Score: Longevity & Your Own Stem Cells

  Beyond the Calcium Score: Longevity & Your Own Stem CellsClick On My Website Below To Schedule A Free 15 Min Zoom Call:www.Over40FitnessHacks.comOver 40 Fitness Hacks SKOOL Group!Get Your Whoop4.0 Here!Dr. Khoshal Latifzai - Rocky Mountain Regenerative Medicinewww.RMRM.comGuest: Dr. Kal Khoshal, MD (Rocky Mountain Regenerative Medicine, Boulder, CO) Focus: Longevity, prevention-first diagnostics, and regenerative therapies (peptides, hormones, PRP, stem cells).Origin story & model: After Dartmouth Med and a Yale EM residency, Dr. Khoshal left the ER due to burnout and the “band-aid” nature of conventional care. He built a cash-pay concierge clinic to spend 60–90 minutes with patients, run deeper diagnostics, and create long-term, prevention-focused plans. He does not bill insurance (patients keep catastrophic coverage), which lets him order better tests and avoid the admin churn.Diagnostics that actually predict risk:Starts from top U.S. mortality drivers (cardiovascular disease, diabetes, cancer, trauma in older adults) and then chooses biomarkers that best reflect true risk, repeating them multiple times per year and explaining results in plain English with written notes.Cancer screening: uses blood tests that detect circulating tumor DNA (ctDNA) as an early, broad screen; positives are followed by imaging (often full-body MRI or targeted MRI/PET).Heart disease: warns that calcium-score CT can miss early non-calcified plaque (common in 40s–60s). Prefers imaging that sees soft plaque before calcification.Whole-body MRI: advocates this for catching issues (like leg artery disease) that localized scans miss—especially relevant to older adults.Therapies & philosophy:Tools include peptides, hormones, PRP, and stem cells, but only after foundations: exercise, nutrition, and social health—there’s no shortcut.Stem cells: strongly prefers autologous (your own) cells that are culture-expanded in a sterile lab, stored, and used over time (IV for systemic repair; guided injections for joints/spine).Cautions against routine allogeneic (donor/cord) cells due to immune reactions and potential long-term autoimmunity.Banking earlier is better, but even older adults can benefit; he shared an 80-year-old scoliosis case that avoided major spine surgery after one procedure.In-clinic process: mini-lipo harvest → lab isolation & expansion → cryostorage (annual maintenance fee ~$350).Advises skepticism about overseas clinics and some cord-blood banks with variable quality/control.If you're interested in online personal training or being a guest on my podcast, "Over 40 Fitness Hacks," you can reach me at [email protected] or visit my website at:www.Over40FitnessHacks.comAdditionally, check out my Yelp reviews for my local business, Evolve Gym in Huntington Beach, at https://bit.ly/3GCKRzV

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• 588: Brad Williams - Why I’m Changing My Fitness Routine After Hernia Surgery

  Why I’m Changing My Fitness Routine After Hernia SurgeryClick On My Website Below To Schedule A Free 15 Min Zoom Call:www.Over40FitnessHacks.comOver 40 Fitness Hacks SKOOL Group!Get Your Whoop4.0 Here!Glutathione Patch:Episode Summary – Post-Hernia Recovery & New Fitness PlanRecovery ContextBrad Williams (Over 40 Fitness Hacks) shares his post-hernia surgery update and how the recovery process is forcing him to pause and re-evaluate his approach. While the downtime is frustrating, it’s giving him space to reset his training and nutrition strategy.Protein-focused intermittent fasting: 180–200g of protein across 2 meals daily.Routine:3 full-body gym sessions (30 minutes, time under tension, circuit style).PT/rebounding on Tues & Thurs.Daily 1–2 mile walks.Planned HIIT trampoline sessions (not always done).Supplements: Glutathione patches boosted caloric expenditure and energy when used, but results declined after stopping.Routine stagnation: Same workouts/walks no longer elevate heart rate beyond Zone 2.Calorie balance: Needs ~1800–2000 calories daily to feel good, but weight loss requires dipping to ~1500, which tanks energy, hormones, and libido.Reluctant to adopt other cardio forms (boxing, yoga, pilates) despite potential benefits.Not interested in “outworking” calories with marathon-style activity like his brother’s volleyball sessions.Red light therapy (Trifecta Light): Tried 12 sessions ($200 unlimited). Minimal personal results (slight arm nerve relief), but his 80-year-old mom noticed some weight loss. Brad is skeptical it’s worth it for him long-term.Glutathione patches (Lifewave): Previously the best measurable boost on Whoop data, may revisit later.Testing over supplement overload: Pausing new supplement trials to focus on his own experiment with diet/training changes.Nutrition Shift:Move from 2 meals → 3 meals daily.Increase protein to 225–250g/day (all from real meat, no whey or pea protein).Lunch carries most carbs/fats, dinner focuses on salad + lean proteins (Mediterranean style: fish, chicken, crab, scallops).Maintain monthly 36–48 hour fasts for autophagy, while loosening daily fasting windows.Training Adjustments:Recommit to HIIT once per week (30s on/off on rebounder with vest, dumbbells, band, oxygen mask).Keep gym/rehab/walking structure, but recognize the need for stimulus change if progress stalls.Biohacker’s Edge:Lean on protein-driven thermogenesis and added lean mass to naturally raise BMR.Hold off on glutathione patches until he proves the new plan works.If you're interested in online personal training or being a guest on my podcast, "Over 40 Fitness Hacks," you can reach me at [email protected] or visit my website at:www.Over40FitnessHacks.comAdditionally, check out my Yelp reviews for my local business, Evolve Gym in Huntington Beach, at https://bit.ly/3GCKRzV

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