The School of Doza Podcast

In this Supplement Stack Series episode, Nurse Doza breaks down the MTHFR gene — the enzyme behind methylation, detoxification, neurotransmitter production, and energy — and explains why the form of folate you take matters if you carry one of the common variants. He walks through The MTHFR Stack by MSW Nutrition: the methyl donors, the methylated B vitamins, and the liver support that keep the methylation cycle turning. If methylation is your bottleneck, start here.

FEATURED PRODUCT
The MTHFR Stack by MSW Nutrition bundles the three formulas Nurse Doza reaches for when methylation support is the goal — Bliss, Boost, and Liver Boost — into one system. Together they cover the methyl donors (betaine/TMG and SAMe), the methylated B vitamins (methylfolate, methylcobalamin, B6 as P-5-P) and glutathione, and the phase II liver pathway where methylation and detoxification meet. Rather than supporting one step and starving the next, the stack works the whole cycle.

👉 Get The MTHFR Stack: https://mthfr.mswnutrition.com/ Launch pricing: $269 through September 30 (retail value $340). $299 from October 1. Discount applies automatically at checkout — no code needed.

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. If you're pregnant or nursing, or take prescription medication, talk with your provider before starting a new supplement.

JOIN THE SCHOOL
Methylation is one of those topics where the labs, the genetics, and the supplement aisle all point in different directions. Inside the School of Doza, members work through it together — and every Wednesday at 1 PM Central there's a live group consult where you can bring your own questions about homocysteine, folate, B12, and what to actually do with an MTHFR result.

👉 Start your free trial: https://community.schoolofdoza.com/c/start-here

5 KEY TAKEAWAYS

MTHFR isn't a niche gene — it's a hub. The MTHFR enzyme converts folate into its active 5-MTHF form, which feeds the methylation cycle behind detoxification, neurotransmitter production, cardiovascular health, brain function, and liver metabolism.

Common variants mean less enzyme activity. The C677T variant is one of the most studied polymorphisms in human genetics and is associated with reduced enzyme activity and higher homocysteine — which is why the form of folate you take matters.

Methylfolate skips the step your enzyme struggles with. Supplemental 5-MTHF is already in the active form, so it doesn't depend on MTHFR conversion the way folic acid does. It's the folate form the stack is built on.

Methyl donors sit upstream of mood. SAMe is the body's universal methyl donor and betaine (TMG) helps recycle homocysteine back to methionine. The stack includes both, which is why Nurse Doza frames methylation support as something that also touches serotonin and dopamine pathways.

The liver is where methylation and detox meet. Phase II detoxification runs through methylation, glutathione conjugation, and sulfation — so supporting glutathione and the phase II pathway is supporting the same system the MTHFR gene serves.

RESOURCES
Based on peer-reviewed literature:

MTHFR C677T — epidemiology and metabolism – Review of the C677T polymorphism, its prevalence, its effect on enzyme activity and homocysteine, and associated conditions. Eur J Med Genet, 2015. https://pubmed.ncbi.nlm.nih.gov/25449138/

Active folate vs. folic acid – Review of 5-MTHF (methylfolate) in human health and why the active form bypasses reduced MTHFR activity. Biomolecules, 2022. https://pmc.ncbi.nlm.nih.gov/articles/PMC9380836/

SAMe and the central nervous system – Systematic review of S-adenosylmethionine, transmethylation, and CNS health. 2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC11435340/

Betaine (TMG) – Comprehensive review of betaine's role as a methyl donor, its effect on homocysteine remethylation, and liver outcomes. Nutrients, 2021. https://pmc.ncbi.nlm.nih.gov/articles/PMC8224793/

Hepatic glutathione – Review of glutathione's synthesis, regulation, and role in liver detoxification. Mol Aspects Med. https://pmc.ncbi.nlm.nih.gov/articles/PMC2596047/

🔗 Connect with Nurse Doza:
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Menopause timing is not purely genetic — and this episode explains how to delay menopause by supporting the systems that actually set the clock. Nurse Doza covers the three estrogens you make across a lifetime (E1, E2, E3), why estradiol supports your heart, cholesterol, and insulin, how PCOS and inflamed fat cells drive estrone production, and which labs to order and when in your cycle to run them. You will also hear why the liver belongs in every hormone conversation.

FEATURED PRODUCT
Liver Boost (Detox) by MSW Nutrition — $111

Your liver is where estrogen gets processed, conjugated, and cleared — which is why this episode keeps circling back to it. Liver Boost (formerly known as Liver Love) is a comprehensive formula designed to support phase I and phase II liver detoxification of environmental toxins, the same two-phase pathway your body uses to handle hormones. When that pathway is working against processed food, alcohol, and years of medication, everything downstream of it gets harder.

Nurse Doza takes it daily alongside Mitochondriac (NAD+ Support) — $119 — a complete bioflavonoid complex with resveratrol, quercetin, and pterostilbene. That pairing is what he names at the close of this episode: support the liver, support the mitochondria.

👉 Get Liver Boost here: https://mswnutrition.com/products/liver-boost

👉 Get Mitochondriac here: https://mswnutrition.com/products/mitochondriac

JOIN THE SCHOOL
If you have ever been told your labs are "normal" while you feel anything but — or you have never had FSH, LH, estradiol, and progesterone run together, at the right point in your cycle — that is exactly the gap this community exists to close. Inside the School of Doza we host a live Ask Me Anything every Wednesday, and it runs like a group consult. You bring your labs, your cycle, your symptoms, the thing your doctor waved off, and we work through it together in real time. These are live sessions, not recordings, so the answers are about your situation.

Your first 7 days are completely free, so you can sit in on an AMA before committing to anything.

👉 Start your free trial: https://community.schoolofdoza.com/c/start-here

5 KEY TAKEAWAYS
1. Menopause timing is not only genetics.

"My mom went through it at this age, so I will too" is only part of the story. Liver health, insulin regulation, inflammation, alcohol, and years of hormonal medication all shape when the transition begins — which makes lifestyle a lever rather than a bystander.

2. You make three different estrogens, and they are not interchangeable.

E1 (estrone) is the estrogen that dominates in menopause and in inflammation. E2 (estradiol) is the reproductive-year estrogen associated with feeling like yourself. E3 (estriol) is made in pregnancy. Standard panels rarely measure all three, which is why "your estrogen is fine" can be an incomplete answer.

3. Estrogen supports the cardiovascular system.

Estradiol is associated with a more favorable lipoprotein profile — lower LDL, higher HDL — and that association is part of why cardiovascular risk in women shifts after menopause. Losing estrogen is not only a fertility event.

4. Estrogen and insulin are linked.

Menopause has been described in the literature as a potential risk factor for insulin resistance independent of age. PCOS — the most common endocrine disorder in women of reproductive age — sits at that same estrogen-insulin intersection, which is why blood sugar belongs in a hormone conversation.

5. Fat cells make estrone.

Adipose tissue is a source of estrone and of inflammatory signaling like IL-6 and TNF-α. Higher body mass index in postmenopausal women is associated with higher circulating sex hormones and higher breast cancer risk — which reframes weight as a hormone input, not just a number on a scale.

TIMESTAMPS
00:00 START – Welcome and episode overview

01:25 – Why women's health can't wait: the hysterectomy statistic

02:30 – Reason 1: The later the menopause, the longer the life

04:20 – Menopause is hormone loss, not just egg loss

06:35 – Estrogen, cholesterol, and cardiovascular protection

09:06 – The three estrogens: E1, E2, and E3 explained

10:48 – Reason 2: Estrogen, insulin, and diabetes risk

13:12 – PCOS as insulin resistance of the ovaries

15:12 – Birth control, IUDs, and what nobody explains

20:01 – Reason 3: Support your healthy estradiol now

24:37 – Reason 4: Fat cells, inflammation, and estrone

27:41 – Hormone replacement and the rest of the panel

29:39 – Which labs to order, and when in your cycle

32:52 – Why this is personal: Nurse Doza's mom

34:46 – Three things you can do today

RESOURCES
1. Journal of the National Cancer Institute, 2002 — Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies: https://pubmed.ncbi.nlm.nih.gov/11959894/

2. Journal of the National Cancer Institute, 2003 — Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women: https://pubmed.ncbi.nlm.nih.gov/12928347/

3. World Journal of Gastroenterology, 2015 — Liver disease in menopause: https://pmc.ncbi.nlm.nih.gov/articles/PMC4491951/

4. Current Vascular Pharmacology, 2019 — Menopause and Non-Alcoholic Fatty Liver Disease: A Review Focusing on Therapeutic Perspectives: https://pubmed.ncbi.nlm.nih.gov/29992886/

5. International Journal of Cancer, 2025 — The estrobolome and breast cancer risk: gut microbial estrogen metabolism: https://pmc.ncbi.nlm.nih.gov/articles/PMC12178105/

CONNECT WITH NURSE DOZA
🔗 Connect with Nurse Doza:

JOIN MY SCHOOL for FREE: https://community.schoolofdoza.com/c/start-here

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In this School of Doza Health Tech Series episode, Nurse Doza breaks down Hume Health—the at-home body scan he keeps in his kitchen, his bathroom, and his clinic. He explains why a single weight reading hides at least four things moving in different directions, why visceral fat is the compartment a standard scale is blind to, and how a three-to-five-second barefoot reading turns diet, training, and sleep changes into a trend line you can actually act on. If you've changed your habits and have no idea whether any of it worked, this is the missing feedback loop.

FEATURED PARTNER
The Hume Pod is the at-home body scan Nurse Doza uses every morning. Step on it barefoot and in three to five seconds it returns estimates for body fat, muscle mass, bone mass, and visceral fat, alongside heart rate, basal metabolic rate, and a calculated body-age score—all synced to a free app that charts the trend over weeks and months instead of handing you one number a day. That's exactly the problem this episode is about: weight alone can't tell you what changed, and the compartments that matter most for metabolic health are the ones a normal scale never shows you. Hume backs the device with a 10-year warranty.

👉 Get the Hume Pod (20% off with code NURSEDOZA): https://humehealth.com Enter NURSEDOZA at checkout. Free worldwide shipping and a 45-day return policy.

The Hume Pod is a consumer wellness device, not a medical device. Body-composition readings are estimates, not diagnostic measurements, and are not intended to diagnose, treat, cure, or prevent any disease. They don't replace lab work or evaluation by a licensed provider. Bioelectrical impedance devices are generally not recommended for people with a pacemaker or other implanted electronic device, or during pregnancy—check with your provider first.

JOIN THE SCHOOL
Data is only useful if you know what to do with it. Inside the School of Doza, members bring exactly this kind of thing—body composition trends, lab panels, what actually moved after eight weeks of changes—to a live group consult every Wednesday at 1 PM Central, run like an Ask Me Anything. Instead of staring at a number and guessing what it means, you get to ask. The first 7 days are free.

👉 Start your free trial: https://community.schoolofdoza.com/c/start-here

5 KEY TAKEAWAYS

Weight is one number hiding at least four. Muscle, fat, water, and bone all move independently. You can drop eight pounds and lose muscle doing it, or gain four while visceral fat trends down—identical scale readings, opposite outcomes. Until you separate the compartments, you're reading an average and calling it a result.

Visceral fat is the compartment a standard scale can't see. The fat stored around the organs behaves differently from the subcutaneous fat you can pinch, and it's the one most consistently examined in the cardiometabolic risk literature. Impedance-based estimates of body fat have been shown to track cardiometabolic risk clustering, in some analyses outperforming waist circumference.

Muscle mass is a longevity metric, not a vanity one. Prospective cohort data consistently associates low skeletal muscle mass with higher all-cause mortality risk. Tracking muscle isn't about the mirror—it's about knowing whether the thing most tied to how you age is moving in the right direction.

Consistency beats precision. At-home impedance devices produce estimates, not DXA-grade measurements, and hydration, food, and time of day all shift a reading. Taken barefoot at the same time each morning under the same conditions, they're reliable enough to show direction—which is the only thing behavior change actually requires.

The device isn't the intervention—the feedback loop is. Research on regular self-weighing and digital self-monitoring links consistent tracking to better adherence in weight-management programs. What changes outcomes isn't owning a scale. It's no longer being able to tell yourself a story about what's happening.

RESOURCES
Based on peer-reviewed literature:

Body composition by BIA & metabolic risk – Cross-sectional analysis associating bioelectrical impedance body-composition measures with metabolic risk factor clustering in middle-aged adults. Preventive Medicine Reports, 2017. https://pmc.ncbi.nlm.nih.gov/articles/PMC5369856/

BIA vs. waist circumference for cardiometabolic risk – Cross-sectional study finding bioelectrical impedance body-fat estimates outperformed waist circumference for predicting cardiometabolic risk in hypertensive subjects. BMC Cardiovascular Disorders, 2015. https://pmc.ncbi.nlm.nih.gov/articles/PMC4357142/

Reliability & accuracy of multi-frequency BIA – Assessment of the reliability, biological variability, and accuracy of multi-frequency bioelectrical impedance analysis for measuring body composition components. Frontiers in Nutrition, 2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC11649400/

Skeletal muscle mass & all-cause mortality – Prospective cohort analysis of skeletal muscle mass and all-cause mortality. Tropical Medicine & International Health, 2023. https://pmc.ncbi.nlm.nih.gov/articles/PMC9945657/

Self-weighing & long-term weight outcomes – Three-year follow-up of participants from a self-weighing randomized controlled trial. Journal of Obesity, 2017. https://pmc.ncbi.nlm.nih.gov/articles/PMC5625756/

🔗 Connect with Nurse Doza:
JOIN MY SCHOOL for FREE: https://community.schoolofdoza.com/c/start-here

YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA

Instagram: https://www.instagram.com/nursedoza/

Website: http://www.nursedoza.com/

LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/

TikTok: https://www.tiktok.com/@nursedoza

Twitter: https://twitter.com/nursedoza

In this Supplement Ingredients Series episode, Nurse Doza breaks down phosphatidylcholine—the phospholipid that makes up much of every cell membrane you have. He explains why your liver and brain hold the biggest stores of it, how the liver uses phosphatidylcholine to package and move fat, and why choline is the precursor your brain needs for acetylcholine, the neurotransmitter behind focus and memory. He also shares the simple two-capsule morning routine he's used for years.

FEATURED PARTNER
BodyBio PC is a phospholipid complex—not a choline salt—which means it delivers phosphatidylcholine in the form your cell membranes are actually built from. That's exactly the distinction Nurse Doza draws in this episode: after cycling through different sources and forms over the years, this is the one that stuck. It's stimulant-free, and his routine is two capsules in the morning on an empty stomach.

👉 Try BodyBio PC (15% off with code DOZA): https://partners.bodybio.com/DOZA

These statements have not been evaluated by the FDA. BodyBio PC is not intended to diagnose, treat, cure, or prevent any disease. If you're pregnant or nursing, or take prescription medication, talk with your provider before starting a new supplement.

JOIN THE SCHOOL
Understanding why a nutrient matters is a lot easier when you're not piecing it together alone. Inside the School of Doza, members work through the foundational stuff—liver support, methylation, cognition, lab interpretation—alongside others asking the same questions, and every Wednesday at 1 PM Central there's a live group consult (think "Ask Me Anything") where you can bring your own labs and supplement questions.

👉 Start your free trial: https://community.schoolofdoza.com/c/start-here

5 KEY TAKEAWAYS

Phosphatidylcholine is structural, not stimulatory. It's the primary phospholipid in your cell membranes, your body makes and stores it naturally, and there's nothing stimulant-like in it—no jitter, no crash to plan around.

Your liver and brain hold the biggest stores. Both organs draw heavily on choline and phosphatidylcholine, which is why one nutrient ends up in both the liver conversation and the cognition conversation.

The liver needs phosphatidylcholine to move fat. Phosphatidylcholine is required to package and export fat out of the liver, which is why choline status keeps showing up in the research on liver fat accumulation.

Choline is the precursor to acetylcholine. That's the neurotransmitter most tied to attention, learning, and memory—so choline status and cognitive performance track together in the literature.

Most adults fall short from food alone. National intake data consistently shows the majority of U.S. adults come in under the Adequate Intake for choline, which makes both food sources (egg yolks, liver, soy) and supplementation worth paying attention to.

RESOURCES
Based on peer-reviewed literature:

Choline requirements in adults – Review of choline's role as an essential nutrient, its storage in liver and brain, and dietary requirements across adult populations. Annual Review of Nutrition. https://pmc.ncbi.nlm.nih.gov/articles/PMC2441939/

Choline metabolism & liver fat – Review of how choline and phosphatidylcholine metabolism relate to hepatic fat export and nonalcoholic fatty liver disease progression. Current Opinion in Gastroenterology, 2012. https://pubmed.ncbi.nlm.nih.gov/22134222/

Dietary choline deprivation & liver function – Controlled feeding study using metabolomic profiling to predict which adults develop liver dysfunction when deprived of dietary choline. FASEB Journal. https://pmc.ncbi.nlm.nih.gov/articles/PMC2909293/

Choline & cognitive performance – Analysis of dietary choline intake against cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort. American Journal of Clinical Nutrition, 2011. https://pubmed.ncbi.nlm.nih.gov/22071706/

Choline intake & long-term cognition – Prospective cohort analysis associating dietary choline intake with incident dementia risk and cognitive performance. American Journal of Clinical Nutrition (Kuopio Ischaemic Heart Disease Risk Factor Study), 2019. https://www.sciencedirect.com/science/article/pii/S0002916522013375

🔗 Connect with Nurse Doza:
JOIN MY SCHOOL for FREE: https://community.schoolofdoza.com/c/start-here

YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA

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Wondering how to lower cortisol naturally? Nurse Doza walks through five practical habits that support a healthier cortisol rhythm: managing everyday stress, getting morning sunlight, cutting screen time at night, using diaphragmatic breath work, and supplying the adrenal glands with the nutrients they run on. The goal is not crushing cortisol. The goal is rhythm, high when it should be high and low when it should be low.

Featured Product
Zen (Stress Relief) by MSW Nutrition, $69

If you are running on caffeine and adrenaline, your body is burning through the exact nutrients it needs to keep cortisol on a healthy rhythm. Zen is built to put them back. It pairs 125 mg of adrenal glandular tissue, sourced from Argentinian bovine for purity, with four standardized adaptogens: Asian ginseng, rhodiola, eleuthero, and schisandra. It also delivers vitamin C, vitamin B6, and pantothenic acid (B5), the nutrients concentrated in adrenal tissue and used up fastest under sustained demand. Most stress formulas give you one botanical. Zen runs four, in one capsule taken twice daily, so you are not juggling a shelf of bottles.

Supports the body’s adaptogenic response

Supports healthy adrenal physiological function

Supports energy production and stamina

Supports the body’s response to everyday stress

👉 Get Zen here: https://zen.mswnutrition.com

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Join the School of Doza
If you have been told to "just manage stress better" and nobody explained what that actually looks like on a Tuesday afternoon, that is exactly the gap the School of Doza fills. Every Wednesday we host a live Ask Me Anything that works like a group consult. You bring the real questions, your labs, your nutrition, the supplement stack you are unsure about, the 3 p.m. crash you cannot shake, and we talk it through together in real time. These are live sessions, not recordings, so you get answers to your situation, not somebody else’s.

Your first 7 days are completely free, so you can sit in on an AMA and see if it is the right fit before you commit to anything.

👉 Start your free trial: https://community.schoolofdoza.com/c/start-here

5 Key Takeaways

Cortisol is not the villain, the flat rhythm is. You need cortisol high in the morning and low at night. Tired but wired, exhausted all day and alert at 11 p.m., is that curve inverted, not a character flaw.

Your body cannot tell stressors apart. Traffic, a hard workout, a skipped meal, an inbox, an infection: the hypothalamus reads all of it as threat and signals the adrenals to release adrenaline and cortisol. Stacking small stressors all day keeps that signal on.

Morning sunlight sets the whole day. Light exposure in the morning suppresses melatonin and supports the natural cortisol awakening response. Kitchen lights and phone screens are not a substitute, and low waking cortisol has been associated with fatigue.

Breath is the fastest lever you have. Inhaling drives the sympathetic side; the exhale is what most stressed people skip. Diaphragmatic belly breathing has been shown to lower cortisol after training, and even a single session can improve heart rate variability and blood pressure. One minute of box breathing fits in any day.

Nutrients are the part nobody accounts for. Pantothenic acid (B5), vitamin B6, vitamin C, rhodiola, and adrenal glandular tissue all show up in the research on cortisol regulation. Those are the ingredients built into Zen, and they are exactly what a chronically activated stress response depletes.

Timestamps
00:00 START – Welcome and episode overview

00:40 – Tired but wired: why the pattern is a rhythm problem, not a discipline problem

02:46 – The goal is rhythm, not crushing cortisol, plus what is happening inside the School

04:50 – Tip 1: Manage your stress better, and how any stressor triggers the adrenal cascade

07:17 – Tip 2: Morning sunlight and the cortisol awakening response

09:37 – When morning sun is not an option: red light panels

11:39 – Tip 3: Less screen time at night, and why darkness is doing real work

13:43 – Tip 4: Breath work, and why the inhale activates fight or flight

16:13 – The trainer who told Nurse Doza he did not know how to breathe

18:38 – Guided belly breathing practice and box breathing

21:00 – Tip 5: Supplements for the adrenal glands, starting with vitamin B5

23:18 – Vitamin B6, GABA, and vitamin C for stress recovery

25:56 – Rhodiola, adaptogens, and bovine adrenal glandular

30:18 – Betaine (TMG) in Bliss for athletes who are overtraining

35:04 – Why Zen ties the lifestyle habits together

Resources

Mayo Clinic, chronic stress and the adrenal alarm system: https://www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/stress/art-20046037

Oura, benefits of morning sunlight and the cortisol awakening response: https://ouraring.com/blog/benefits-of-morning-sunlight/

National Sleep Foundation, screen use disrupts sleep time: https://www.thensf.org/screen-use-disrupts-precious-sleep-time/

Ma et al. 2017, diaphragmatic breathing, attention and cortisol: https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2017.00874/full

ScienceDirect, pantethine and adrenal cortex function: https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/pantethine

Stachowicz and Lebiedzinska 2016, diet components and cortisol (betaine, rhodiola, vitamin C): https://link.springer.com/article/10.1007/s00217-016-2772-3

Vitamin B6, GABA, anxiety and depression: https://www.sciencedirect.com/science/article/pii/S2049080122014236

WebMD, adrenal extract overview: https://www.webmd.com/vitamins-supplements/adrenal-extract

Zen (Stress Relief) by MSW Nutrition: https://mswnutrition.com/products/zen

Join the School of Doza, first 7 days free: https://community.schoolofdoza.com/c/start-here

Connect with Nurse Doza
🔗 Connect with Nurse Doza:

JOIN MY SCHOOL for FREE: https://community.schoolofdoza.com/c/start-here

YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA

Instagram: https://www.instagram.com/nursedoza/

Website: http://www.nursedoza.com/

LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/

TikTok: https://www.tiktok.com/@nursedoza

Twitter: https://twitter.com/nursedoza