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The School of Doza Podcast

NURSE DOZA
The School of Doza Podcast
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308 episodes

  • The School of Doza Podcast

    MTHFR and Your Liver: The Connection Nobody Explains

    2026/09/28 | 33 mins.
    Most people handed an MTHFR result never get it explained. This episode connects MTHFR and liver function — why so much of that gene's work happens in the liver, what methylation actually means in plain language, and how the pathway ties into glutathione, detoxification, and mood. Nurse Doza also covers why methylfolate alone is rarely the whole picture, and what's worth discussing with your own provider. Education, not a protocol.

    Featured Product
    The MTHFR Stack — Bliss + Boost + Liver Boost

    Three formulas built around the same pathway this episode is about. Bliss is a sublingual shot with SAMe and TMG (trimethylglycine) — it supports biochemical reactions that require methyl groups and supports neurotransmitter synthesis and healthy mood. Boost is a morning stick pack built on methylcobalamin — B12 already in its methylated, active form — alongside methylated B vitamins, electrolytes, and antioxidant nutrients (heads up: it contains caffeine, roughly 95 mg). Liver Boost is the capsule piece, formulated to support phase I and phase II liver detoxification.

    The rhythm is simple: Boost in the morning, Bliss whenever it fits your day, Liver Boost with a meal.

    👉 Get The MTHFR Stack here: https://mswnutrition.com/products/mthfr-stack

    If you take medication, run any new supplement by your provider first.

    Join the School of Doza
    If you walked out of an appointment holding a genetic result and no explanation, that's exactly the gap the School of Doza was built to close.

    Every Wednesday at 1pm Central we run a live Ask Me Anything — a group consult where you bring your labs, your questions, and whatever's actually going on with you, and Nurse Doza answers directly. It's live only, so you're getting a real conversation, not a recording.

    We're in the middle of The Liver Course right now — live class plus Q&A every Tuesday at 5:30pm Central. October 6 is the MTHFR and the Liver class, which goes deeper than this episode with diagrams, handouts, and live questions. October 13 closes the series with Building Your Liver Protocol.

    Your first 7 days are free, so you can sit in on a class and an AMA before you decide anything.

    👉 Start your free trial: https://community.schoolofdoza.com/c/start-here

    5 Key Takeaways

    MTHFR isn't abstract — a lot of its work happens in your liver. The gene is expressed throughout the body, but the liver is where a large share of methylation activity plays out, which is why a variant shows up as a liver-support question and not just a vitamin question.

    Methylation is a cycle, not a single step. Folate gets converted to its active form, that feeds the methionine–SAMe cycle, homocysteine gets cleared down the transsulfuration pathway into cysteine, and cysteine is the rate-limiting input for glutathione. Slow the cycle down anywhere and everything downstream feels it.

    Glutathione is the connection point. It's one of the most abundant antioxidants the body makes, it's produced largely in the liver, and it's central to phase II detoxification — which is the same phase where methylation lives.

    Folate status and mood are genuinely linked. Folate deficiency is documented as a risk factor for major depressive disorder and for poorer response to antidepressants, and L-methylfolate has research behind it as a supportive option. Variants in MTHFR can reduce how well someone converts dietary folate and folic acid to the active form.

    Methylfolate alone often isn't the whole picture. The research on SAMe and betaine (TMG) points to the rest of the cycle mattering too — betaine supplementation lowers serum homocysteine, and SAMe plus betaine has been studied as an add-on with more effect than SAMe alone.

    Timestamps
    00:00 START – Welcome and episode overview

    02:08 – Who this episode is for, plus the Liver Course dates

    04:27 – Why he started ordering MTHFR on everyone, including himself

    06:27 – The gene is everywhere in the body, but concentrated in the liver

    08:51 – How common variants are, and what epigenetics actually means

    11:16 – Folic acid vs folate, and everything else the gene does

    13:34 – The homocysteine and glutathione pathway

    16:20 – The mood connection: folate, serotonin, and the gut

    18:46 – What a clinic rotation taught him about prescribing B9

    21:06 – Where serotonin is made, and where folate is stored

    23:24 – Third: the pathway needs daily vitamins and supplements

    25:50 – SAMe, methionine, and betaine (TMG)

    29:11 – Fourth: what changes, and how to measure it

    31:32 – Phase I and phase II detox, and the full methylation stack

    33:49 – What to check, and closing

    Resources

    DNA Methylation in Liver Disease (Int J Mol Sci) — https://pmc.ncbi.nlm.nih.gov/articles/PMC7662478/

    MTHFR Polymorphisms, Homocysteine and Disease Risk (Genes) — https://pmc.ncbi.nlm.nih.gov/articles/PMC12027316/

    Glutathione Overview (ScienceDirect Topics) — https://www.sciencedirect.com/topics/medicine-and-dentistry/glutathione

    Glutathione Conjugation and Detoxification (PMC) — https://pmc.ncbi.nlm.nih.gov/articles/PMC2696075/

    L-Methylfolate and Depressive Symptoms (Neurology) — https://www.neurology.org/doi/10.1212/WNL.92.15_supplement.P3.9-057

    Folate, MTHFR and Depression (PMC) — https://pmc.ncbi.nlm.nih.gov/articles/PMC4750636/

    SAMe Plus Betaine as Add-On Therapy (PMC) — https://pmc.ncbi.nlm.nih.gov/articles/PMC4303396/

    Betaine Supplementation and Serum Homocysteine (Nutrition Research) — https://www.sciencedirect.com/science/article/abs/pii/S0271531724000691

    Betaine, B12, Choline, Glutathione and Diabetes Parameters (PubMed) — https://pubmed.ncbi.nlm.nih.gov/39442756/

    Connect
    🔗 Connect with Nurse Doza:
    JOIN MY SCHOOL for FREE: https://community.schoolofdoza.com/c/start-here
    YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA
    Instagram: https://www.instagram.com/nursedoza/
    Website: http://www.nursedoza.com/
    LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/
    TikTok: https://www.tiktok.com/@nursedoza
    Twitter: https://twitter.com/nursedoza
  • The School of Doza Podcast

    What the SONA Vagus Nerve Earpiece Actually Does?

    2026/09/24 | 1 mins.
    In this Wellness Tech Series episode, Nurse Doza breaks down SONA — an AI-powered earpiece that delivers gentle vagus nerve stimulation at the cymba concha, the one spot in the outer ear where a branch of the vagus nerve reaches the surface. He explains how the paired app reads heart rate variability in real time, why HRV is a window into stress and recovery, and how short guided breath and audio sessions are designed to fit a schedule with no room for a long meditation.

    FEATURED PARTNER
    SONA is an AI-powered wearable vagus nerve stimulator. It sits on the ear and delivers low-level, non-invasive electrical stimulation at the cymba concha — the auricular branch of the vagus nerve — while the companion app tracks heart rate variability so users can watch their own trend across a session. Guided breath work and audio pairings are built in, the app has no monthly subscription, and the device ships with a 30-day money-back guarantee and a 1-year warranty. It's the tool Nurse Doza reaches for when the problem isn't knowing how to relax — it's having ten minutes and a way to tell whether anything actually happened.

    👉 Get SONA (15% off with code NURSEDOZA): https://sona.pxf.io/k41Dxx

    SONA is a consumer wellness device, not a medical device, and nothing here is medical advice. If you are pregnant, have a pacemaker or other implanted electrical device, a heart-rhythm condition, or a history of seizures, talk with your provider before using any form of nerve stimulation. This page contains affiliate links.

    JOIN THE SCHOOL
    Nervous system work is a lot easier when you're not guessing on your own. Inside the School of Doza, members compare notes on the tools that actually earn a place in a daily routine — sleep, stress, recovery, labs — and every Wednesday at 1 PM Central there's a live group consult where you can bring your specific questions.

    👉 Start your free trial: https://community.schoolofdoza.com/c/start-here

    5 KEY TAKEAWAYS

    Chronic stress is a physiology problem, not a willpower problem. The stress response was built for short bursts. When it never gets a chance to downshift, telling yourself to calm down doesn't move the system — the input has to reach the nervous system itself.

    The vagus nerve is reachable through the ear. A branch of the vagus nerve surfaces at the cymba concha in the outer ear, which is why transcutaneous auricular vagus nerve stimulation is delivered there. It's the anatomical reason an earpiece can engage this pathway without anything invasive.

    HRV is a trend to watch, not a verdict. Heart rate variability reflects how flexibly the body shifts between stress and recovery. A single reading says very little; the useful signal is the pattern over days and weeks, which is what makes in-app feedback worth having.

    Feedback is what makes a practice stick. Breath work, meditation, and yoga all support the same system. Pairing them with a real-time measurement turns "I think that helped" into something a person can actually track — and track-ability is what keeps a routine alive.

    Consistency beats session length. Short daily sessions that survive a real calendar compound the way training does. Follow the manufacturer's recommended session guidance rather than self-escalating duration.

    RESOURCES
    Based on peer-reviewed literature:

    Why the ear – Butt MF, et al. "The anatomical basis for transcutaneous auricular vagus nerve stimulation." Journal of Anatomy, 2020;236(4):588–611. https://onlinelibrary.wiley.com/doi/10.1111/joa.13122

    taVNS, HRV & mental stress – Drost L, Schulz A, Möck A, Vögele C. "Effects of taVNS on physiological responses and cognitive performance during a mental stressor." Cognitive, Affective, & Behavioral Neuroscience, 2025;25(6):1655–1666. (Sham-controlled RCT, n=41: higher RMSSD during active stimulation; self-report and cognitive performance unchanged.) https://link.springer.com/article/10.3758/s13415-025-01341-w

    What HRV actually indexes – Laborde S, Mosley E, Thayer JF. "Heart Rate Variability and Cardiac Vagal Tone in Psychophysiological Research — Recommendations for Experiment Planning, Data Analysis, and Data Reporting." Frontiers in Psychology, 2017;8:213. https://www.frontiersin.org/articles/10.3389/fpsyg.2017.00213/full

    Slow breathing & HRV – Laborde S, et al. "Effects of voluntary slow breathing on heart rate and heart rate variability: A systematic review and a meta-analysis." Neuroscience & Biobehavioral Reviews, 2022;138:104711. https://pubmed.ncbi.nlm.nih.gov/35623448/

    Non-invasive vagal approaches, reviewed – Gitler A, Bar Yosef Y, Kotzer U, Levine AD. "Harnessing non-invasive vagal neuromodulation: HRV biofeedback and SSP for cardiovascular and autonomic regulation (Review)." Medicine International, 2025;5(4):37. https://www.spandidos-publications.com/10.3892/mi.2025.236

    🔗 Connect with Nurse Doza:
    JOIN MY SCHOOL for FREE: https://community.schoolofdoza.com/c/start-here

    YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA

    Instagram: https://www.instagram.com/nursedoza/

    Website: http://www.nursedoza.com/

    LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/

    TikTok: https://www.tiktok.com/@nursedoza

    Twitter: https://twitter.com/nursedoza
  • The School of Doza Podcast

    Why Your Kid Keeps Getting Sick (And What Actually Helps)

    2026/09/21 | 32 mins.
    Child immune system support isn't about stopping every cold — it's about knowing which ones are normal. Nurse Doza breaks down how a school-age immune system actually develops, what's worth a closer look, and five things you can do at home: sleep, food, the right supplements, movement, and nervous system care. Plus the one nutrient that keeps coming back low on lab work.

    Featured Product
    The D (4-Month Supply) — $75

    Vitamin D receptors sit on immune cells throughout the body — in the gut, the sinuses, the lungs — and vitamin D is one of the most commonly low results on a standard lab panel. The D pairs vitamin D3 (cholecalciferol) with vitamin K2 as MK-7 in a single daily capsule, and one bottle runs four months. One habit, one bottle, the whole season covered.

    👉 Get The D here: https://mswnutrition.com/products/the-d

    Ask your child's pediatrician before giving a child any supplement, and ask them to check a vitamin D level so you're working from a number instead of a guess.

    Join the School of Doza
    If you're the parent who has been through four rounds of the same cold since school started and nobody will tell you whether that's normal, this is the room for you.

    Every Wednesday at 1pm Central we hold a live Ask Me Anything that runs like a group consult — bring your labs, your supplement questions, or what's going on at home and get direct guidance in the room. It's live only, so you're getting answers to your situation, not a recording of somebody else's.

    The Liver Course is also running right now — a live class plus Q&A every Tuesday, six weeks, wrapping with Building Your Liver Protocol. If you've ever been told your labs look fine and you still feel off, that's the one to sit in on.

    Your first 7 days are completely free.

    👉 Start your free trial: https://community.schoolofdoza.com/c/start-here

    5 Key Takeaways

    Kids getting sick is part of how a young immune system learns. The goal is not zero colds — it is knowing which pattern is normal development and which pattern is worth bringing to your pediatrician.

    Sleep is immune infrastructure, not downtime. CDC/NIOSH training materials note that restricting sleep to four hours for a single night dropped natural killer cell activity to an average of 72% of a rested night, and six nights of short sleep cut influenza vaccine antibody production by more than half.

    Color on the plate is the simplest nutrition rule kids will actually follow. Fermented foods (kefir, sauerkraut, pickles, miso) supply probiotics; green bananas, plantains, jicama, yams and asparagus feed them as prebiotics; berries and dark leafy greens carry the antioxidants.

    Vitamin D is the one most often missing. In a trial of otitis-prone children, 1,000 IU of vitamin D3 daily reduced the risk of acute otitis media, and the protection tracked with final blood levels reaching roughly 40 ng/mL or higher — a level most standard reference ranges would still call "normal" well below.

    Movement and nervous system care round it out. Physical activity helps the body stay resilient against infection, and Nurse Doza makes the case from his chiropractic practice that regular adjustments support the nervous system that regulates the immune response.

    Timestamps
    00:00 START – Welcome and episode overview

    00:39 – The cold that never leaves the house, and the 2am question

    02:05 – What's happening right now inside the School of Doza

    04:05 – Thing #1: Sleep, and why it is the foundation of the immune system

    06:05 – Four hours of sleep and what happens to natural killer cell activity

    07:20 – Melatonin, dark rooms, and the difference between hours and depth

    08:55 – Sleep and how well a vaccine actually works

    09:48 – Thing #2: Eat the right food — vitamin D, sunlight, and fatty fish

    12:30 – Eating the rainbow, and why yellow-and-white plates fall short

    14:27 – Probiotic and prebiotic foods kids will actually eat

    16:30 – Thing #3: The right supplements — vitamin D3 with K2

    18:30 – What vitamin D level to aim for, and why "in range" is not the same as optimal

    20:05 – Thing #4: Exercise — 60 minutes of real play, every day

    23:49 – Thing #5: The one most families skip — chiropractic and the nervous system

    30:52 – Test, don't guess — and the closing ask

    Resources
    1. Sleep and the Immune System — CDC / NIOSH https://www.cdc.gov/niosh/work-hour-training-for-nurses/longhours/mod2/05.html

    2. Melatonin, sleep and immune regulation — PMC8602722 https://pmc.ncbi.nlm.nih.gov/articles/PMC8602722/

    3. How To Build Up Your Kid's Immune System — Cleveland Clinic https://health.clevelandclinic.org/how-to-boost-your-kids-immunity

    4. Whole foods for kids' immune health — CHOC https://health.choc.org/how-to-strengthen-your-childs-immune-system-with-whole-foods/

    5. Vitamin D supplementation reduces the risk of acute otitis media in otitis-prone children (Marchisio et al., Pediatr Infect Dis J, 2013) — PMID 23694840 https://pubmed.ncbi.nlm.nih.gov/23694840/

    6. Treatment and Prevention of Infections in Pediatric Acute-Onset Neuropsychiatric Syndrome (vitamin D section) — Cooperstock et al., 2017 https://journals.sagepub.com/doi/full/10.1089/cap.2016.0151

    7. New Study Unveils Relationship Between Chiropractic Care and Immune Response — International Chiropractors Association https://www.chiropractic.org/new-study-unveils-relationship-between-chiropractic-care-and-immune-response/

    8. Immune Function: Top 5 research papers — Asia-Pacific Chiropractic Journal https://www.apcj.net/site_files/4725/upload_files/ImmuneFunctionTop5(1).pdf

    9. The D (4-Month Supply) — MSW Nutrition https://mswnutrition.com/products/the-d

    10. School of Doza — start your free 7-day trial https://community.schoolofdoza.com/c/start-here

    11. $99 lab review with Nurse Doza https://labs.nursedoza.com

    Connect with Nurse Doza
    🔗 Connect with Nurse Doza:

    JOIN MY SCHOOL for FREE: https://community.schoolofdoza.com/c/start-here

    YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA

    Instagram: https://www.instagram.com/nursedoza/

    Website: http://www.nursedoza.com/

    LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/

    TikTok: https://www.tiktok.com/@nursedoza

    Twitter: https://twitter.com/nursedoza
  • The School of Doza Podcast

    MTHFR Gene Explained: Why Your Folate Isn't Working (And What to Take)

    2026/09/17 | 2 mins.
    In this Supplement Stack Series episode, Nurse Doza breaks down the MTHFR gene — the enzyme behind methylation, detoxification, neurotransmitter production, and energy — and explains why the form of folate you take matters if you carry one of the common variants. He walks through The MTHFR Stack by MSW Nutrition: the methyl donors, the methylated B vitamins, and the liver support that keep the methylation cycle turning. If methylation is your bottleneck, start here.

    FEATURED PRODUCT
    The MTHFR Stack by MSW Nutrition bundles the three formulas Nurse Doza reaches for when methylation support is the goal — Bliss, Boost, and Liver Boost — into one system. Together they cover the methyl donors (betaine/TMG and SAMe), the methylated B vitamins (methylfolate, methylcobalamin, B6 as P-5-P) and glutathione, and the phase II liver pathway where methylation and detoxification meet. Rather than supporting one step and starving the next, the stack works the whole cycle.

    👉 Get The MTHFR Stack: https://mthfr.mswnutrition.com/ Launch pricing: $269 through September 30 (retail value $340). $299 from October 1. Discount applies automatically at checkout — no code needed.

    These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. If you're pregnant or nursing, or take prescription medication, talk with your provider before starting a new supplement.

    JOIN THE SCHOOL
    Methylation is one of those topics where the labs, the genetics, and the supplement aisle all point in different directions. Inside the School of Doza, members work through it together — and every Wednesday at 1 PM Central there's a live group consult where you can bring your own questions about homocysteine, folate, B12, and what to actually do with an MTHFR result.

    👉 Start your free trial: https://community.schoolofdoza.com/c/start-here

    5 KEY TAKEAWAYS

    MTHFR isn't a niche gene — it's a hub. The MTHFR enzyme converts folate into its active 5-MTHF form, which feeds the methylation cycle behind detoxification, neurotransmitter production, cardiovascular health, brain function, and liver metabolism.

    Common variants mean less enzyme activity. The C677T variant is one of the most studied polymorphisms in human genetics and is associated with reduced enzyme activity and higher homocysteine — which is why the form of folate you take matters.

    Methylfolate skips the step your enzyme struggles with. Supplemental 5-MTHF is already in the active form, so it doesn't depend on MTHFR conversion the way folic acid does. It's the folate form the stack is built on.

    Methyl donors sit upstream of mood. SAMe is the body's universal methyl donor and betaine (TMG) helps recycle homocysteine back to methionine. The stack includes both, which is why Nurse Doza frames methylation support as something that also touches serotonin and dopamine pathways.

    The liver is where methylation and detox meet. Phase II detoxification runs through methylation, glutathione conjugation, and sulfation — so supporting glutathione and the phase II pathway is supporting the same system the MTHFR gene serves.

    RESOURCES
    Based on peer-reviewed literature:

    MTHFR C677T — epidemiology and metabolism – Review of the C677T polymorphism, its prevalence, its effect on enzyme activity and homocysteine, and associated conditions. Eur J Med Genet, 2015. https://pubmed.ncbi.nlm.nih.gov/25449138/

    Active folate vs. folic acid – Review of 5-MTHF (methylfolate) in human health and why the active form bypasses reduced MTHFR activity. Biomolecules, 2022. https://pmc.ncbi.nlm.nih.gov/articles/PMC9380836/

    SAMe and the central nervous system – Systematic review of S-adenosylmethionine, transmethylation, and CNS health. 2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC11435340/

    Betaine (TMG) – Comprehensive review of betaine's role as a methyl donor, its effect on homocysteine remethylation, and liver outcomes. Nutrients, 2021. https://pmc.ncbi.nlm.nih.gov/articles/PMC8224793/

    Hepatic glutathione – Review of glutathione's synthesis, regulation, and role in liver detoxification. Mol Aspects Med. https://pmc.ncbi.nlm.nih.gov/articles/PMC2596047/

    🔗 Connect with Nurse Doza:
    JOIN MY SCHOOL for FREE: https://community.schoolofdoza.com/c/start-here

    YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA

    Instagram: https://www.instagram.com/nursedoza/

    Website: http://www.nursedoza.com/

    LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/

    TikTok: https://www.tiktok.com/@nursedoza

    Twitter: https://twitter.com/nursedoza
  • The School of Doza Podcast

    How to Delay Menopause: What Actually Sets the Timeline?

    2026/09/14 | 33 mins.
    Menopause timing is not purely genetic — and this episode explains how to delay menopause by supporting the systems that actually set the clock. Nurse Doza covers the three estrogens you make across a lifetime (E1, E2, E3), why estradiol supports your heart, cholesterol, and insulin, how PCOS and inflamed fat cells drive estrone production, and which labs to order and when in your cycle to run them. You will also hear why the liver belongs in every hormone conversation.

    FEATURED PRODUCT
    Liver Boost (Detox) by MSW Nutrition — $111

    Your liver is where estrogen gets processed, conjugated, and cleared — which is why this episode keeps circling back to it. Liver Boost (formerly known as Liver Love) is a comprehensive formula designed to support phase I and phase II liver detoxification of environmental toxins, the same two-phase pathway your body uses to handle hormones. When that pathway is working against processed food, alcohol, and years of medication, everything downstream of it gets harder.

    Nurse Doza takes it daily alongside Mitochondriac (NAD+ Support) — $119 — a complete bioflavonoid complex with resveratrol, quercetin, and pterostilbene. That pairing is what he names at the close of this episode: support the liver, support the mitochondria.

    👉 Get Liver Boost here: https://mswnutrition.com/products/liver-boost

    👉 Get Mitochondriac here: https://mswnutrition.com/products/mitochondriac

    JOIN THE SCHOOL
    If you have ever been told your labs are "normal" while you feel anything but — or you have never had FSH, LH, estradiol, and progesterone run together, at the right point in your cycle — that is exactly the gap this community exists to close. Inside the School of Doza we host a live Ask Me Anything every Wednesday, and it runs like a group consult. You bring your labs, your cycle, your symptoms, the thing your doctor waved off, and we work through it together in real time. These are live sessions, not recordings, so the answers are about your situation.

    Your first 7 days are completely free, so you can sit in on an AMA before committing to anything.

    👉 Start your free trial: https://community.schoolofdoza.com/c/start-here

    5 KEY TAKEAWAYS
    1. Menopause timing is not only genetics.

    "My mom went through it at this age, so I will too" is only part of the story. Liver health, insulin regulation, inflammation, alcohol, and years of hormonal medication all shape when the transition begins — which makes lifestyle a lever rather than a bystander.

    2. You make three different estrogens, and they are not interchangeable.

    E1 (estrone) is the estrogen that dominates in menopause and in inflammation. E2 (estradiol) is the reproductive-year estrogen associated with feeling like yourself. E3 (estriol) is made in pregnancy. Standard panels rarely measure all three, which is why "your estrogen is fine" can be an incomplete answer.

    3. Estrogen supports the cardiovascular system.

    Estradiol is associated with a more favorable lipoprotein profile — lower LDL, higher HDL — and that association is part of why cardiovascular risk in women shifts after menopause. Losing estrogen is not only a fertility event.

    4. Estrogen and insulin are linked.

    Menopause has been described in the literature as a potential risk factor for insulin resistance independent of age. PCOS — the most common endocrine disorder in women of reproductive age — sits at that same estrogen-insulin intersection, which is why blood sugar belongs in a hormone conversation.

    5. Fat cells make estrone.

    Adipose tissue is a source of estrone and of inflammatory signaling like IL-6 and TNF-α. Higher body mass index in postmenopausal women is associated with higher circulating sex hormones and higher breast cancer risk — which reframes weight as a hormone input, not just a number on a scale.

    TIMESTAMPS
    00:00 START – Welcome and episode overview

    01:25 – Why women's health can't wait: the hysterectomy statistic

    02:30 – Reason 1: The later the menopause, the longer the life

    04:20 – Menopause is hormone loss, not just egg loss

    06:35 – Estrogen, cholesterol, and cardiovascular protection

    09:06 – The three estrogens: E1, E2, and E3 explained

    10:48 – Reason 2: Estrogen, insulin, and diabetes risk

    13:12 – PCOS as insulin resistance of the ovaries

    15:12 – Birth control, IUDs, and what nobody explains

    20:01 – Reason 3: Support your healthy estradiol now

    24:37 – Reason 4: Fat cells, inflammation, and estrone

    27:41 – Hormone replacement and the rest of the panel

    29:39 – Which labs to order, and when in your cycle

    32:52 – Why this is personal: Nurse Doza's mom

    34:46 – Three things you can do today

    RESOURCES
    1. Journal of the National Cancer Institute, 2002 — Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies: https://pubmed.ncbi.nlm.nih.gov/11959894/

    2. Journal of the National Cancer Institute, 2003 — Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women: https://pubmed.ncbi.nlm.nih.gov/12928347/

    3. World Journal of Gastroenterology, 2015 — Liver disease in menopause: https://pmc.ncbi.nlm.nih.gov/articles/PMC4491951/

    4. Current Vascular Pharmacology, 2019 — Menopause and Non-Alcoholic Fatty Liver Disease: A Review Focusing on Therapeutic Perspectives: https://pubmed.ncbi.nlm.nih.gov/29992886/

    5. International Journal of Cancer, 2025 — The estrobolome and breast cancer risk: gut microbial estrogen metabolism: https://pmc.ncbi.nlm.nih.gov/articles/PMC12178105/

    CONNECT WITH NURSE DOZA
    🔗 Connect with Nurse Doza:

    JOIN MY SCHOOL for FREE: https://community.schoolofdoza.com/c/start-here

    YouTube: https://www.youtube.com/channel/UCwcKyagDi468WscAOWM5VHA

    Instagram: https://www.instagram.com/nursedoza/

    Website: http://www.nursedoza.com/

    LinkedIn: https://www.linkedin.com/in/jonathan-mendoza-dc-aprn-np-c-0609a038/

    TikTok: https://www.tiktok.com/@nursedoza

    Twitter: https://twitter.com/nursedoza
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About The School of Doza Podcast
Nurse Doza’s Podcast comes to life in a very interactive way. Sure you can listen to the podcast, but this is just the beginning of your education in health. Every week, Nurse Doza dives into new health subjects and encourages you to submit your questions to be answered on the podcast, newsletter, YouTube, LinkedIn, and every other way that you like to take in educational media.
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