The mindbodygreen Podcast

“Skin is our most visible biomarker of how we're aging on the inside,” explains Saranya Wyles, M.D., Ph.D.  Wyles, a dermatologist, regenerative medicine scientist, and the director of the Regenerative Dermatology & Skin Longevity Lab at the Mayo Clinic, joins us today to unpack how the skin reflects systemic aging and the emerging therapies shaping the future of regenerative dermatology. - The skin’s connection to longevity (~3:45) - Markers of skin aging (~5:20) - Senescent cells & systemic aging (~6:35) - 5 pillars of skinspan (~8:25) - How to eat for better skin (~10:20) - The role of exercise (~12:30) - The best topicals (~13:55) - Sunscreen & morning sunlight exposure (~17:05) - What are peptides (~20:20)  - Lasers & longevity (~25:20) - Procedures to be mindful of (~32:40) - Underrated skin habits (~33:35) - The future of skin longevity (~35:15) - Cognitive function & skin health (~39:50) - Hair loss (~42:30) Referenced in the episode:  - Follow Wyles on Instagram (@drwyles.derm) - Check out her research (https://pubmed.ncbi.nlm.nih.gov/?term=saranya+wyles)   - The Baltimore Longitudinal Study of Aging (https://www.nia.nih.gov/research/labs/blsa/about)  - Participate in the Skin Aging And Longevity Understanding Database (SALUD) (https://www.mayo.edu/research/clinical-trials/cls-20578108)  We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. Learn more about your ad choices. Visit megaphone.fm/adchoices

Here’s the story of some scientists in the 1980s who tried to cause heart disease in rabbits. Instead, they stumbled upon a discovery so surprising it challenged everything we thought we knew about cardiovascular health—and may hold a powerful lesson for human longevity. This story isn’t just about rabbits. It’s about us. - How we eat. - Who we eat with. - And how guilt, stress, love, and presence shape the way our bodies respond to food. Emerging science shows that eating in a relaxed, connected state activates the parasympathetic nervous system—supporting digestion, blood sugar balance, and heart health. In other words: how you eat may matter as much as what you eat. Link to the actual study Chapters 00:00 – The mysterious rabbit experiment 01:35 – A result that made no sense 02:30 – The detail researchers almost missed 04:00 – What this teaches us about eating & stress 05:00 – Why love may protect the heart 🎙️ This new format episode, hosted by founder and co-CEO Jason Wachob, is from the mindbodygreen podcast, where science meets meaning—and small shifts lead to big health changes. If this story resonated with you: 👍 Like this video 💬 Share your thoughts in the comments 🔔 Subscribe for more science-backed stories on longevity, nutrition, and whole-body health Read more here: https://www.mindbodygreen.com/ Shop our supplements: https://shop.mindbodygreen.com/ Join 1M+ subscribers on their journey towards strong and healthy: https://www.mindbodygreen.com/newsletters  Follow us:  Instagram: @mindbodygreen   TikTok: @mindbodygreen Learn more about your ad choices. Visit megaphone.fm/adchoices

“Most women are doing too much cardio and not enough resistance training,” explains Jaime Seeman, M.D.  Seeman, a board-certified Obstetrician-Gynecologist and member of mindbodygreen’s scientific board of advisors, joins us today to dive deep into how women can support muscle, hormones, and metabolic health across every decade of life. - Dr. Seeman’s morning routine (~3:40) - How to do fasting the right way (~6:35) - How to eat for body recomposition (~8:30) - Balancing macros (~11:00) - Optimizing your nutrition (~15:55) - Wearables, macros, & hormones (~17:55) - Nutrition & exercise for your 20s (~19:00) - Health advice for your 30s (~20:55) - Jaime’s personal experience postpartum (~25:25) - Seeman’s prescription for training (~27:10) - How to make the most of your training (~28:30) - Health in your 40s & 50s (~32:00) - Understanding the nuance with HRT (~34:00) - Seeman’s favorite supplement, creatine (~38:00) - Her hot takes (~41:30) Referenced in the episode:  - Follow Dr. Seeman on Instagram (@doctorfitandfabulous) - Check out her website (https://www.doctorfitandfabulous.com/)  - Listen to her podcast The Fit and Fabulous Podcast (https://podcasts.apple.com/us/podcast/the-fit-and-fabulous-podcast/id1575100757)  - Watch her TEDx Talk (https://www.youtube.com/watch?v=dJIw-hljICY)  - Listen to her previous episode (Muscle, metabolism, & mindset for women | Jamie Seeman, M.D.)   We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. Learn more about your ad choices. Visit megaphone.fm/adchoices

“It is more dangerous to your health not to have muscle mass than to have excess body fat,” explains Rocío Salas-Whalen, M.D. Salas-Whalen, a board-certified Endocrinologist, Obesity Medicine specialist, and widely recognized as one of the earliest adopters of GLP-1 therapies in the United States, joins us today to explain how GLP-1s work, who truly benefits, and the crucial steps you need to take to protect your metabolism along the way. - How to know if GLP-1s are right for you (~4:00) - Are there longevity benefits of GLP-1s? (~5:10) - Types of body composition profiles (~7:00) - How to protect your muscle mass on GLP-1s (~8:50) - Protein recommendations (~12:00) - Common mistakes (~13:00) - Conversations to have with your provider (~14:25) - Getting off GLP-1s (~18:05) - The most important steps to build muscle (~19:30) - HRT + GLP-1s (~21:30) - Who should not take GLP-1s (~25:05) - The importance of lifestyle (~27:55) - The internal gains of GLP-1s (~29:45) - The mindset needed for long-term success (~31:35) - GLP-1s for minors? (~37:55) - The future of this space (~42:00) Referenced in the episode:  - Follow Salas-Whalen on Instagram (@drsalaswhalen)  - Pick up her book, Weightless (https://weightlessthebook.com/)   - Work with her (https://www.nyendocrinology.com/home)  - Liraglutide in mild to moderate Alzheimer’s disease (https://www.nature.com/articles/s41591-025-04106-7)  We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. Learn more about your ad choices. Visit megaphone.fm/adchoices

“There are hundreds, maybe thousands, of drug repurposing opportunities just waiting to be uncovered,” explains David Fajgenbaum, M.D.  David Fajgenbaum, M.D., physician-scientist, bestselling author of Chasing My Cure, co-founder of Every Cure, and leader in the global push for drug repurposing, joins us today to explain why the cures of tomorrow may already be on pharmacy shelves today—and how his team is racing to uncover them. - From college athlete to ICU (~3:15) - Finding a cure (~7:20) - Hope needs to drive action (~9:45) - Repurposing drugs (~11:10) - Use cases of generic drugs (~13:30) - Lithium for bipolar & Alzheimer’s (~16:00) - Lidocaine & breast cancer (~17:25) - GLP-1 for longevity benefits (~19:20) - Increasing awareness in the healthcare system (~20:10) - The 3 main hurdles for repurposing drugs (~22:00) - Opportunities in the space (~23:10) - 14 advanced repurpose treatments (~28:00) - The power of AI (~32:50) - Using AI for personalized medicine (~34:30) - AI for treatment options (~37:45) - Common drugs with big potential (~41:00) - The future of healthcare & drug discovery (~44:50) - How you can help (~49:30) Referenced in the episode:  - Follow Fajgenbaum on Instagram (@dfajgenbaum)  - Check out his website (https://davidfajgenbaum.com/)  - Listen to his previous episode on the mbg podcast  (https://podcasts.apple.com/us/podcast/life-lessons-from-a-doctor-who-almost-died-from/id1246494475?i=1000470061486) - Pick up his book, Chasing My Cure (https://www.amazon.com/Chasing-My-Cure-Doctors-Action/dp/1524799637/)  - Listen to his TED Talk (https://www.youtube.com/watch?v=sb34MfJjurc)   - Learn more about Every Cure (https://everycure.org/) We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. Learn more about your ad choices. Visit megaphone.fm/adchoices