Psychopharmacology and Psychiatry Updates

In this episode, we explore the growing threat of xylazine — a veterinary sedative increasingly found in illicit drug supplies — and what clinicians need to know when naloxone simply isn't enough. Dr. David Gorelick breaks down the current evidence on diagnosis, treatment, and the critical gaps that remain.
Faculty: David A. Gorelick, M.D., Ph.D., D.L.F.A.P.A., F.A.S.A.M.
Host: Richard Seeber, M.D.
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Earn 0.5 CME: Quick Take Vol. 82
Xylazine ("Tranq Dope") Overdose: What Clinicians Should Know

In this episode, we explore how to select the right initial treatment for depression using the updated CANMAT guidelines. How do severity, patient preference, and treatment availability shape your first clinical move? Dr. Sagar Parikh breaks down the evidence on psychotherapy, antidepressants, and when to combine both.
Faculty: Sagar V. Parikh, M.D.
Host: Richard Seeber, M.D.
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Earn 1.25 CME: Rethinking Depression Treatment: An Update of CANMAT's Guidelines
Selecting the Initial Depression Treatment

In this episode, we explore the hidden dangers of leaving antipsychotics running long after a hospital delirium episode has resolved. Could a medication prescribed to keep your patient safe in the short term actually be harming them months later — and what does the latest evidence say about stopping it?
Faculty: Scott Beach, M.D.
Host: Richard Seeber, M.D.
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Earn 0.5 CME: Quick Take Vol. 82
Deprescribing Antipsychotics Post-Delirium: Why It Matters

In this episode, we explore the practical dosing, initiation, and conversion strategies for paliperidone palmitate and risperidone long-acting injectables in schizophrenia. How do you manage a missed six-month injection — reload or continue? Dr. Brian Miller breaks down everything you need to know to prescribe these formulations with confidence.
Faculty: Brian Miller, M.D., Ph.D., M.P.H.
Host: Richard Seeber, M.D.
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Earn 0.75 CME: Use of Long-Acting Injectable Antipsychotics in Schizophrenia
LAIs in Practice: Paliperidone & Risperidone

In this episode, we explore the surprisingly thin evidence base behind antipsychotic switching — one of psychiatry's most common clinical maneuvers. Dr. Oliver Freudenreich breaks down a landmark systematic review and shares six practical tips to help clinicians switch antipsychotics safely and confidently.
Faculty: Oliver Freudenreich, M.D.
Host: Richard Seeber, M.D.
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Earn 0.5 CMEs: Quick Take Vol. 82
Switching Oral Antipsychotics: Six Strategies and Tips