"The Cognitive Revolution" | AI Builders, Researchers, and Live Player Analysis

Abhi Mahajan (@owlposting) explains how AI is reshaping biology and medicine, including foundation models to predict cancer treatment response and why he’s both skeptical and optimistic about current results. Helen Toner unpacks CSET’s “When AI Builds AI” report and why automated AI R&D is a major source of strategic surprise. Jeremie Harris then explores our lack of control over superhuman AI systems, fragile US–China coordination, and how to maintain situational awareness in a rapidly shifting landscape.

Use the Granola Recipe Nathan relies on to identify blind spots across conversations, AI research, and decisions: https://recipes.granola.ai/r/4c1a6b10-5ac5-4920-884c-4fd606aa4f53
LINKS:

Abhi Mahajan's Owl Posting site

Heuristics for lab robotics article

Deep Research on Noetik AI

Sponsors:

GovAI:
GovAI was founded ten years ago on the belief that AI would end up transforming our world. Ten years later, the organization is at the forefront of trying to help decision-makers in government and industry navigate the transition to advanced AI.  GovAI is now hiring Research Scholars (one-year positions for those transitioning into AI policy) and Research Fellows (longer-term roles for experienced researchers). Both roles offer significant freedom to pursue policy research, advise decision-makers, or launch new initiatives. Applications close 15 February 2026. Apply at: https://www.governance.ai/opportunities

Blitzy:
Blitzy is the autonomous code generation platform that ingests millions of lines of code to accelerate enterprise software development by up to 5x with premium, spec-driven output. Schedule a strategy session with their AI solutions consultants at https://blitzy.com

Tasklet:
Tasklet is an AI agent that automates your work 24/7; just describe what you want in plain English and it gets the job done. Try it for free and use code COGREV for 50% off your first month at https://tasklet.ai

Serval:
Serval uses AI-powered automations to cut IT help desk tickets by more than 50%, freeing your team from repetitive tasks like password resets and onboarding. Book your free pilot and guarantee 50% help desk automation by week four at https://serval.com/cognitive

PRODUCED BY:

https://aipodcast.ing

Part 1 of this live special dives into AI for Science, U.S. AI policy, and the behavior of AI agents in open-ended environments. James Zou explains how interpretability and virtual labs of AI agents can accelerate scientific discovery. Sam Hammond assesses the Biden administration’s AI policy, U.S.–Gulf AI deals, and the odds current AIs are conscious. Shoshannah Tekofsky shares insights from studying agent performance and emergent behavior in the AI Village.

Use the Granola Recipe Nathan relies on to identify blind spots across conversations, AI research, and decisions: https://recipes.granola.ai/r/4c1a6b10-5ac5-4920-884c-4fd606aa4f53
LINKS:

Model human wellness project doc

AI Village 2025 findings report

Sponsors:

GovAI:
GovAI was founded ten years ago on the belief that AI would end up transforming our world. Ten years later, the organization is at the forefront of trying to help decision-makers in government and industry navigate the transition to advanced AI.  GovAI is now hiring Research Scholars (one-year positions for those transitioning into AI policy) and Research Fellows (longer-term roles for experienced researchers). Both roles offer significant freedom to pursue policy research, advise decision-makers, or launch new initiatives. Applications close 15 February 2026. Apply at: https://www.governance.ai/opportunities

Blitzy:
Blitzy is the autonomous code generation platform that ingests millions of lines of code to accelerate enterprise software development by up to 5x with premium, spec-driven output. Schedule a strategy session with their AI solutions consultants at https://blitzy.com

Tasklet:
Tasklet is an AI agent that automates your work 24/7; just describe what you want in plain English and it gets the job done. Try it for free and use code COGREV for 50% off your first month at https://tasklet.ai

Serval:
Serval uses AI-powered automations to cut IT help desk tickets by more than 50%, freeing your team from repetitive tasks like password resets and onboarding. Book your free pilot and guarantee 50% help desk automation by week four at https://serval.com/cognitive

PRODUCED BY:

https://aipodcast.ing

Alexis Carlier, founder of Asymmetric Security, explains how assuming AGI-level intelligent labor should transform cybersecurity from reactive triage to proactive, continuous digital forensics. He breaks down today’s threat landscape—from “spray and pray” cybercrime to nation-state IP theft and North Korean “remote workers.” The conversation explores Asymmetric’s AI agents for deep investigations, their services-first approach to business email compromise, and how specialized digital forensics may differentially accelerate defensive AI capabilities.

Use the Granola Recipe Nathan relies on to identify blind spots across conversations, AI research, and decisions: https://bit.ly/granolablindspot

Sponsors:

GovAI:

GovAI was founded ten years ago on the belief that AI would end up transforming our world. Ten years later, the organization is at the forefront of trying to help decision-makers in government and industry navigate the transition to advanced AI.  GovAI is now hiring Research Scholars (one-year positions for those transitioning into AI policy) and Research Fellows (longer-term roles for experienced researchers). Both roles offer significant freedom to pursue policy research, advise decision-makers, or launch new initiatives. Applications close 15 February 2026. Apply at: https://www.governance.ai/opportunities

Blitzy:

Blitzy is the autonomous code generation platform that ingests millions of lines of code to accelerate enterprise software development by up to 5x with premium, spec-driven output. Schedule a strategy session with their AI solutions consultants at https://blitzy.com

Serval:

Serval uses AI-powered automations to cut IT help desk tickets by more than 50%, freeing your team from repetitive tasks like password resets and onboarding. Book your free pilot and guarantee 50% help desk automation by week four at https://serval.com/cognitive

Tasklet:

Tasklet is an AI agent that automates your work 24/7; just describe what you want in plain English and it gets the job done. Try it for free and use code COGREV for 50% off your first month at https://tasklet.ai

CHAPTERS:

(00:00) About the Episode

(04:20) Defining AGI and jaggedness

(12:27) Modern cyber threat landscape (Part 1)

(19:10) Sponsors: GovAI | Blitzy

(22:17) Modern cyber threat landscape (Part 2)

(29:58) AI-powered cyber defense (Part 1)

(33:31) Sponsors: Serval | Tasklet

(36:20) AI-powered cyber defense (Part 2)

(42:20) Inside digital forensics workflows

(51:52) Bootstrapping AI cyber defense

(59:17) Shaping the capability frontier

(01:08:44) Future of automated forensics

(01:17:59) Outro

PRODUCED BY:

https://aipodcast.ing

Blitzy founders Brian and Sid break down how their “infinite code context” system lets AI autonomously complete over 80% of major enterprise software projects in days. They dive into their dynamic agent architecture, how they choose and cross-check different models, and why they prioritize advances in AI memory over fine-tuning. The conversation also covers their 20¢/line pricing model, the path to 99%+ autonomous project completion, and what this all means for the future software engineering job market.

Sponsors:

Blitzy:
Blitzy is the autonomous code generation platform that ingests millions of lines of code to accelerate enterprise software development by up to 5x with premium, spec-driven output. Schedule a strategy session with their AI solutions consultants at https://blitzy.com

Tasklet:
Tasklet is an AI agent that automates your work 24/7; just describe what you want in plain English and it gets the job done. Try it for free and use code COGREV for 50% off your first month at https://tasklet.ai

Serval:
Serval uses AI-powered automations to cut IT help desk tickets by more than 50%, freeing your team from repetitive tasks like password resets and onboarding. Book your free pilot and guarantee 50% help desk automation by week four at https://serval.com/cognitive

CHAPTERS:

(00:00) About the Episode

(03:02) AGI effects without AGI

(07:07) Domain-specific context engineering

(16:54) Dynamic harness and evals (Part 1)

(17:00) Sponsors: Blitzy | Tasklet

(20:00) Dynamic harness and evals (Part 2)

(30:42) Graphs, RAG, and memory (Part 1)

(30:49) Sponsor: Serval

(32:26) Graphs, RAG, and memory (Part 2)

(41:17) Model zoo and memory

(50:07) Planning, scaling, and parallelism

(56:13) Pricing, onboarding, and autonomy

(01:04:24) Closing the last 20%

(01:12:34) Strange behaviors and judges

(01:22:23) Reasoning budgets and autonomy

(01:33:36) Fine-tuning, benchmarks, and training

(01:42:31) Securing AI-generated code

(01:49:52) Future of software work

(01:57:05) Outro

PRODUCED BY:

https://aipodcast.ing

SOCIAL LINKS:

Website: https://www.cognitiverevolution.ai

Twitter (Podcast): https://x.com/cogrev_podcast

Twitter (Nathan): https://x.com/labenz

LinkedIn: https://linkedin.com/in/nathanlabenz/

Youtube: https://youtube.com/@CognitiveRevolutionPodcast

Apple: https://podcasts.apple.com/de/podcast/the-cognitive-revolution-ai-builders-researchers-and/id1669813431

Spotify: https://open.spotify.com/show/6yHyok3M3BjqzR0VB5MSyk

This crossover episode from the Latent Space podcast features Mark Zuckerberg and Priscilla Chan on the 10-year anniversary of the Chan Zuckerberg Initiative and their expanded Biohub vision. They discuss how a “Frontier Biology Lab” working in sync with a “Frontier AI Lab” could enable breakthroughs like a Virtual Cell and true N-of-1 precision medicine. The conversation covers the acquisition of Evolutionary Scale and ESM3, new biological data collection at scale, and how AI-powered biology might transform drug discovery and disease prevention.

Sponsors:

Blitzy:
Blitzy is the autonomous code generation platform that ingests millions of lines of code to accelerate enterprise software development by up to 5x with premium, spec-driven output. Schedule a strategy session with their AI solutions consultants at https://blitzy.com

Framer:
Framer is an enterprise-grade website builder that lets business teams design, launch, and optimize their.com with AI-powered wireframing, real-time collaboration, and built-in analytics. Start building for free and get 30% off a Framer Pro annual plan at https://framer.com/cognitive

Serval:
Serval uses AI-powered automations to cut IT help desk tickets by more than 50%, freeing your team from repetitive tasks like password resets and onboarding. Book your free pilot and guarantee 50% help desk automation by week four at https://serval.com/cognitive

Tasklet:
Tasklet is an AI agent that automates your work 24/7; just describe what you want in plain English and it gets the job done. Try it for free and use code COGREV for 50% off your first month at https://tasklet.ai

CHAPTERS:

(00:00) About the Episode

(04:27) CZI origins and focus

(08:29) Why tools over cures

(14:43) Virtual cells and imaging (Part 1)

(20:19) Sponsors: Blitzy | Framer

(23:24) Virtual cells and imaging (Part 2)

(25:22) Data diversity and grounding

(32:30) Evaluating models and Biohub (Part 1)

(37:53) Sponsors: Serval | Tasklet

(40:42) Evaluating models and Biohub (Part 2)

(41:06) Future healthcare and aging

(53:39) Modeling scales and immunity

(58:53) Timelines, data, and collaboration

(01:04:01) Outro

PRODUCED BY:

https://aipodcast.ing

SOCIAL LINKS:

Website: https://www.cognitiverevolution.ai

Twitter (Podcast): https://x.com/cogrev_podcast

Twitter (Nathan): https://x.com/labenz

LinkedIn: https://linkedin.com/in/nathanlabenz/

Youtube: https://youtube.com/@CognitiveRevolutionPodcast

Apple: https://podcasts.apple.com/de/podcast/the-cognitive-revolution-ai-builders-researchers-and/id1669813431

Spotify: https://open.spotify.com/show/6yHyok3M3BjqzR0VB5MSyk