The DUTCH Podcast

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In this episode, Dr. Felice Gersh joins host Dr. Jaclyn Smeaton and DUTCH founder Mark Newman for a deep-dive on progesterone: its physiological roles, concerns around standard-of-care prescribing practices, and more. 
Their conversation also explores: 
Progesterone’s role as more than an endometrial protectant 
Supraphysiologic allopregnanolone created by oral micronized progesterone 
The physiological benefits of cyclic dosing versus continuous dosing 
How the gut microbiome impacts progesterone metabolism 
The need for more research on oral micronized progesterone and dosing methods 
Show Notes
Learn more about Dr. Gersh’s practice Integrative Medical Group of Irvine and check out her books! 
Read Dr. Smeaton’s article on oral micronized progesterone in menopause. 
Become a DUTCH Provider to get access to comprehensive patient reports, peer-reviewed and validated research, and expert clinical support.

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In this episode, Dr. Bindiya Gandhi joins host Dr. Jaclyn Smeaton to explore GLP-1 receptor agonists through a whole-person, root-cause lens with a particular focus on women’s health. 
Their discussion also covers: 
How GLP-1s work, who benefits most, and how to cease therapy successfully 
The role of leptin resistance in weight struggles 
The risk of muscle loss and bone health during GLP-1 therapy 
Using GLP-1s as part of a comprehensive protocol, including optimizing gut health, strength training, and managing cortisol and sex hormones 
Considerations for menopausal women using hormone therapy in addition to GLP-1s 
Show Notes 
Learn more about Dr. Bindiya Gandhi and follow her on Instagram @drbindiyamd! 
Check out our DUTCH Article on GLP-1s and perimenopause. 
Become a DUTCH Provider to get access to peer-reviewed and validated research, comprehensive patient reports, and expert clinical support.

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This conversation between Dr. Sonya Jensen and host Dr. Jaclyn Smeaton covers the science of how stress disrupts female hormone health and the emotions women carry that perpetuate that disruption. They also discuss the physiological mechanisms of chronic stress and how hormone testing can tell patients their stress story. 
This episode also highlights: 
How chronic stress and sustained cortisol production can lead to suppressed progesterone 
The downstream effects of resentment and unexpressed emotion 
How a patient’s emotional history connects to their symptoms 
The cortisol/cortisone ratio and what it can tell practitioners and patients about fatigue, low motivation, anxiety, and burnout 
Using the Cortisol Awakening Response on the DUTCH Plus as a clinical conversation tool
Show Notes 
Learn more about Dr. Sonya Jensen and follow her on Instagram @drsonyajensen! 
Check out Dr. Sonya’s book, Heal Your Hormones, Reclaim Yourself. 
Read the ovarian aging study mentioned in this episode. 
Become a DUTCH Provider to get access to comprehensive patient reports, peer-reviewed and validated research, and expert clinical support.

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In this episode, Dr. Saru Bala and host Dr. Jaclyn Smeaton discuss the connection between hormones, the nervous system, and mood, specifically PMS and PMDD, from an integrative medicine perspective.  
Their discussion also highlights: 
Why hormonal shifts affect mood and the neuroscience behind those shifts 
The distinction between PMS and PMDD and why they are often dismissed as anxiety or depression 
How the luteal phase can reflect baseline health, including nutrition, lifestyle, and stress levels 
The importance of comprehensive testing and how those markers impact mood and cycle symptoms 
Key supplementation and lifestyle recommendations 
Show Notes 
Learn more about Dr. Saru Bala and follow her on Instagram @drsarubala! 
Become a DUTCH Provider to get access to comprehensive patient reports, peer-reviewed and validated research, and expert clinical support.

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In this episode, Dr. Mark Holthouse joins Dr. Jaclyn Smeaton and DUTCH founder Mark Newman to take a closer look at a recent peer-reviewed publication from Precision Analytical, Inc. in Frontiers in Reproductive Health, examining how different testing methods hold up when it comes to monitoring male TRT in clinical practice.
Their discussion also covers:
Common misconceptions about how creams and gels show up in saliva testing and why the numbers can be misleading
What the clinical data actually shows about dosing accuracy across different testing modalities 
When to use serum, urine, and other testing approaches can be leveraged to optimize treatment.
How under or overdosing risks can be reduced by matching the right test to the right clinical question
Why advancing best practices in integrative medicine requires continually revisiting what the evidence supports
Show Notes 
Read our DUTCH Article on the Frontiers study, Mark Newman’s commentary, and the full study here. 
Check out the resources mentioned in this episode: 
The topical progesterone cream study in Fertility and Sterility 
The transdermal progesterone study from Climacteric 
Good Energy mentioned by Dr. Holthouse 
The study on the cardiovascular safety of TRT in the New England Journal of Medicine 
The study on testosterone threshold levels and skeletal muscle strength 
Become a DUTCH Provider to gain access to comprehensive patient reports, peer-reviewed and validated research, and expert clinical support.