MDS Podcast

Prodromal autonomic dysfunction has emerged as an important area of research in understanding Lewy body diseases, including Parkinson's disease, and dementia with Lewy bodies. Dr. Michelle Matarazzo sits down with three experts in the field, Dr. Abhimanyu Mahajan, Dr. Alison Yarnall, and Dr. David Goldstein to discuss the current evidence behind various disturbances and how they may precede classic motor and cognitive symptoms, such as cardiovascular, gastrointestinal, urinary, and thermoregulatory disturbances. Together they discuss how these early non-motor manifestations may be considered integral features of the disease process.
Read the Scientific Issue on this topic.

Genetic ataxias have many non-motor features, such as fatigue, sleep disorders, and cognitive dysfunction. In this episode, Dr. Orlando Barsottini and Dr. Christofer Stephen discuss the most common non-motor symptoms and how to approach them.

Dr. Michele Matarazzo sits down with Dr. Rebecca Wallings to discuss  how two of the most important genetic forms for Parkinson's disease, LRRK2 and GBA1, influence immune response to bacterial simulation. Their discussion highlights a potential link between genetics, environment, and inflammation in Parkinson’s disease.

Journal CME is available until March 18, 2027



Read the article.

In this episode, Dr. Orlando Barsottini and Dr. Malco Rossi discuss the main imaging findings and clues for the the diagnosis of genetic and sporadic ataxias.

In this episode Dr. Hugo Morales Briceno and Dr. Ai Huey Tan discuss how to approach deafness-dystonia syndrome and its etiological differential diagnoses.

Read the discussed case.