Clinical trials are the gold standard for testing the safety and efficacy of a treatment or drug, and a keystone in modern medicine. But their grinding timelines and skyrocketing price tags are hindering development and, ultimately, costing lives.Natasha Loder, The Economist’s health editor, asks Sir Martin Landray, the boss of Protas, a clinical-trial organisation, what can be learned from his pioneering RECOVERY covid-19 trial. Euan Ashley, a cardiologist at Stanford University, explains how to use wearable technology to conduct wholly digital clinical trials. Plus, Alejandro Frangi of the University of Leeds says virtual clinical trials that use computers to model medical interventions can save time and money. Alok Jha, The Economist's science and technology editor, hosts.We would love to hear from you. Please fill out our listener survey at economist.com/babbagesurvey.For full access to The Economist’s print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our weekly science newsletter at economist.com/simplyscience. Hosted on Acast. See acast.com/privacy for more information.

Antimicrobial resistance killed over a million people in 2019. That figure is expected to rise to ten million by 2050. Antibiotics remain vital to modern medicine, but this hidden pandemic of drug-resistant superbugs is driving scientists to explore possible alternatives. One type of therapy in particular is attracting serious scientific interest: bacteriophages. Phages are viruses that can destroy bacteria. In the 1920s, phage therapies were used widely against infections, but much of the world abandoned the idea following the discovery of penicillin. Some parts of the former Soviet Union, though, have continued to use phage therapies. What can governments and international companies learn from this medicine?Gilead Amit, The Economist’s science correspondent, travels to the Eliava Institute in Tbilisi, Georgia to find out how phage therapies have been used there over the last century. He speaks to the director, Mzia Kutateladze, head of phage production, Vakho Pavlenishvili, and from the therapy centre: Davit Sturia, Lia Nadareishvili and Lana Abesadze. Barry Rud, a Canadian patient attending the clinic, discusses his experience. Steffanie Strathdee, who leads phage research at the University of California, San Diego, explains the renewed international interest in bacteriophages. Alok Jha, The Economist’s science and technology editor, hosts.We would love to hear from you. Please fill out our listener survey at economist.com/babbagesurvey.The Economist is also seeking applications for the 2023 Richard Casement internship. The successful candidate will spend three months with us in London writing about science and technology. More details here: economist.com/casement2023.For full access to The Economist’s print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our weekly science newsletter at economist.com/simplyscience. Hosted on Acast. See acast.com/privacy for more information.

The use of drones in the war in Ukraine has been increasing. Unmanned vehicles capture battlefield images, relay co-ordinates, and strike targets in Ukraine and even Russia. Whether purpose-built military devices or off-the-shelf civilian technology, the drones are having an outsized impact. How are they influencing battles? And what do they mean for the future of warfare?Oliver Carroll, our correspondent in Ukraine, explores the purpose and effectiveness of drones in the war. Ulrike Franke of the European Council on Foreign Relations explains the potential that drone technology offers to armies. Plus, The Economist’s Benjamin Sutherland travels to Kyiv, to investigate how engineers in underground workshops are tinkering with consumer drones and turning them into military machines. Alok Jha, The Economist’s science and technology editor, hosts.  If you love Babbage, why not work with us? We’re hiring for an Assistant Audio Producer to work on the show. Apply by May 15th.The Economist is also seeking applications for the 2023 Richard Casement internship. The successful candidate will spend three months with us in London writing about science and technology. More details here: economist.com/casement2023.For full access to The Economist’s print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our weekly science newsletter at economist.com/simplyscience. Hosted on Acast. See acast.com/privacy for more information.

The vast majority of the energy used on Earth comes from fossil fuels. But as governments enact climate-friendly policies, electric grids need to be decarbonised, by using renewable-energy sources. And much more electricity needs to be generated too—to power transport, homes and heavy industry. Despite its urgency, redesigning electric grids is both a political and technological challenge. How can such a revolution happen?Host Kenneth Cukier explores the mechanics of how electric grids work and how to upgrade them with The Economist’s Hal Hodson. Hal travels to Drax, a power station in the north of England, to visualise this supersized circuit with Bruce Heppenstall, the plant’s director. Plus, Hal asks Gerhard Salge, the chief technology officer of Hitachi Energy, how the latest generation of high voltage direct current cables will transform energy systems.If you love Babbage, why not work with us? We’re hiring for an Assistant Audio Producer to work on the show. Apply by May 15th.For full access to The Economist’s print, digital and audio editions subscribe at economist.com/podcastoffer and sign up for our weekly science newsletter at economist.com/simplyscience. Hosted on Acast. See acast.com/privacy for more information.

Since the launch of OpenAI’s ChatGPT almost six months ago, little else has occupied the minds of technologists. Generative artificial intelligence—capable of producing media like text, images and audio in response to prompts—seems to be improving every day, with many technology companies developing and releasing their own competing systems.As the AI revolution accelerates, the technology is being used in ever more creative ways, companies are discovering its potential, causing unease among many content-creators and white-collar professionals, whose jobs seem to be at risk. The story of automation changing the world of work is not a new one. But the speed, the visibility and the hype surrounding generative AI can seem alarming. How worrying is it?The Economist’s Abby Bertics and Arjun Ramani explain how large language models work, the risk posed by the technology—and what to do about it. Callum Williams, our senior economics writer, ponders the potential for economic disruption as generative AI enters the workplace. Plus, Tom Standage, The Economist’s deputy editor explores the question of regulating this emerging technology without hindering innovation. Kenneth Cukier hosts.Listen to all of our coverage of the artificial intelligence revolution at economist.com/AI-pods. If you love Babbage, why not work with us? We’re hiring for an Assistant Audio Producer to work on the show. Apply by May 15th. Hosted on Acast. See acast.com/privacy for more information.