DDT Method Podcast — Peptides, Performance Enhancement and Advanced Protocols with Drew Donaldson

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Jake Benson is back on the DDT Method Podcast for round three, and it opens on a question a lot of you have sent in: why does kratom (or THC, or the third energy drink) stop working, and why is it so hard to stop?
Jake breaks down what's actually going on under the hood: dopamine as a value scale that tags what's worth remembering, why a substance you rely on is really "paying the withdrawal cost" for you, the kappa-opioid and dynorphin drag that makes the benefit slide under the cost, and why two people on the exact same dose need completely different protocols.

5 Key Takeaways
Why a substance you rely on is "paying the withdrawal cost" for you, and the signal Drew uses to know when kratom has stopped being worth it.
The first question Jake asks anyone who wants to quit THC, and why skipping it is the reason most attempts fail in the first uncomfortable week.
Why the supplement that changed your life will give someone else diarrhea, and what that says about every generic dopamine protocol.
The six different reasons people procrastinate, and why "low dopamine" is almost never the right label for any of them.
The single cost Jake removes from a stimulant-dependent entrepreneur's day, and how his own schedule does it without cutting the caffeine first.

Chapters
0:00 Cold open: the substance pays the withdrawal cost
1:59 Drew's kratom case study: why it stops working
9:29 THC, "not addictive," and why there's no THC protocol
14:13 How to actually quit: intent, gatekeepers, and the replacement routine
18:54 No magic supplement: the magnesium story, 9-MeBC, bromantane
22:07 Transcendence: the app Jake is building
24:48 A word from Amplify Wellness, Janus Optimize, and DDT coaching
26:25 Dopamine, undressed: what it actually does
31:23 The dopamine tax: news, social media, and why you were supposed to be bored
35:58 Decide what's yours to care about, and the Brick
39:18 Weaponizing dopamine: intent, procrastination, quiet moments
44:39 The six causes of procrastination
49:33 The entrepreneur avatar: stimulants, the transition tax, and Jake's 2:30 AM schedule
58:20 A word from Amplify Wellness, Janus Optimize, and the Skool group
1:01:42 Euphoria: the four layers of a pre-workout
1:13:04 Wrap-up and where to find Jake

Connect with Jake Benson
Instagram – https://www.instagram.com/jakeyb_43/
Better Through Biology – https://www.betterthroughbiology.com

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Big Pharma just came for retatrutide. Eli Lilly filed six lawsuits against research peptide sellers, a med spa chain, and a compounding pharmacy, compounders got cut off from tirzepatide and semaglutide, and a biologics classification is coming that would make Lilly the only place to get reta. Jay Campbell is back on the DDT Method Podcast to break down who Lilly is targeting and why, what a biologic classification does to generics and compounders, why renaming your GLP-3 isn't a workaround, how Lilly let the research market do its marketing for free for three years, and why the play now is four- and five-pathway agonists and oral delivery, starting with BioLean 4XR, the oral strip BioLongevity Labs is building to replace what Lilly took off the table.

5 Key Takeaways
The one question Jay asked a stranger who had lost 60 pounds on retatrutide
What a year of DEXAs and full-body scans on FLGR-242 users showed about the organ-growth
Why Eli Lilly waited three years to act on retatrutide, and what a biologic classification means for RUO
Jay’s six-day experiment on SLU-PP-915 vs high-dose SLU-PP-332
The line between sharing your protocol and making a claim for influencers

Chapters
0:00 Foundation before enhancement: Jay's new book and the 54-year-old on reta
9:47 FLGR-242 one year in: what it is, what it fixed, and what users are seeing
18:35 Non-responders, why DEXA misleads, and how to dose FLGR-242
24:29 How albumin binding made FLGR-242 possible, and Drew's upcoming log
33:08 Bio-IGF: the once-a-week IGF product coming next
38:00 Clotho for the already-optimized: senses, sexual performance, and the kidney trial
44:54 Grounding, sunlight, melanotan, and Drew's foundation reset
50:31 Big Pharma just killed retatrutide: Eli Lilly, biologic classification, and BioLean 4XR
58:59 The six lawsuits, 14,000 websites, and compounders cut off
1:06:22 The influencer legal line: what you can and can't say
1:11:46 SLU-PP-915 vs high-dose SLU-PP-332: the verdict
1:18:23 ATX at high dose, high-dose SS31, and the BioRecharge stack
1:24:28 MOTS-c protocols and phasing AMPK against mTOR
1:29:16 The future of delivery: patches, sprays, and the black market risk
1:36:00 Living Leaner, Longer, Stronger and where to find Jay

Connect with Jay Campbell
Website: https://jaycampbell.com
Living Leaner, Longer, Stronger on Amazon: https://www.amazon.com/dp/B0HDJ41BWS
Fully Optimized Health (private membership): https://jaycampbell.com/foh/
Instagram: https://www.instagram.com/jaycampbell1971/ (
X: https://x.com/JayCampbell333
Substack: https://substack.com/@jaycampbell333

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Chris Gross stepped on stage at the Tampa Pro the leanest he's been since 2018 and the best he's ever looked, and he did it eating 6,000 to 7,000-calorie refeeds up to twice a week. In this episode of the DDT Method Podcast, Drew sits down with Chris and his coach Mike Nassif to break down the contest prep that made it work: why your peak offseason intake should be your refeed day from week one, how high days keep T4 to T3 conversion and free T3 from tanking in a calorie deficit, and why the frequency of those days should go up, not down, as you get leaner. If you've ever stalled in a fat loss phase and blamed metabolic adaptation, this is the mechanism explained by people who manage it for a living.
This isn't just for bodybuilders. Anyone chasing extreme fat loss, whether that's a contest prep, a photoshoot, or just getting truly shredded, will get a repeatable framework here: how to structure refeed days when cutting, why hunger is the signal your diet is working, when a coach introduces a GLP in prep and why not at the start, how to manage fatigue without seven days of cardio, and what the blood work looked like three weeks out and one week post-show. The back half covers the health side of enhancement: the diagnostics Mike requires for his athletes, how to get an echocardiogram and calcium score without a fight, and the blood pressure protocol Drew wishes every client followed.

5 Key Takeaways
The refeed rule a pro coach uses to keep the metabolism from downregulating in prep.
What "metabolic downregulation" actually looks like on a blood panel.
Why zero stress mattered as much as the diet, and what Mike tells athletes who can't just switch it off.
When to bring a GLP into a prep
The diagnostics Mike requires for enhanced athletes.

Chapters
00:00 Contest prep from a different angle
02:41 The order: 6 to 7,000 calories after six high-carb meals
05:27 Why it didn't break thermodynamics
06:22 Mike's high-day rule: your offseason intake is your refeed
09:22 What metabolic downregulation actually means
10:56 T4 to T3, free T3, and allostatic load
12:52 Zero stress: the other half of the result
14:18 How Chris actually de-stressed
16:30 Coaching athletes who can't just "have fun"
18:25 What changed this prep vs. every prep before
19:54 Stair stepper over treadmill, and the 8-to-5-weeks-out protocol
22:51 Managing fatigue and the timeline Chris kept breaking
26:14 Coach-client communication as a performance variable
28:14 Drew's guardrail: this only works between two professionals
33:37 Peptides in contest prep: what Mike actually uses and when
37:05 Dosing, recovery, and a sponsorship handshake
38:42 Drew's 20-day experiment and inflammatory markers
40:10 Why Chris's hunger came back at higher doses
42:18 Why Mike keeps hunger present on a GLP
44:28 Post-show: back to baseline weight before the reverse
45:29 The blood work: best of Chris's career, three weeks out and one week after
48:48 The peak cycle, on the record
49:36 Clearance time, health supplementation, and doing the little things
53:12 Drew gives Chris his flowers: continued education
55:08 Bioregulators: Chris's two-compound self-experiment
57:47 Calcium scores, echocardiograms, and where to get them cheap
59:52 Mike's required diagnostics for enhanced athletes
01:02:24 Blood pressure: how, how often, and which cuff
01:05:05 Tracking BP with a wearable
01:06:18 Educate yourself, monitor your health
01:08:04 Where to find Chris and Mike

Connect with the Guests
Chris Gross
Instagram: https://www.instagram.com/chrisjohn___/
NeoGen Labs

Mike Nassif
Instagram: https://www.instagram.com/mike_nassif/
Email: mike@camp-jansen.com

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Description
Half the WWE roster is in the best shape of their lives and the internet has one question: what are they doing? Jay Ferruggia is the common denominator. He coaches CM Punk, Rey Mysterio, Chad Gable and a who's who of WWE, MLB, NFL and UFC athletes, wrote the Men's Fitness Hardgainer column for a decade, and has spent 30 years fixing the same problems on himself that his clients bring him.
His answer is the opposite of what most lifters are doing. Less volume, harder sets, shorter warm-ups, wider rep brackets, and a logbook that is loosely held. More carbs, less fat, more meals, no fasting. Morning sun, sleep, a walk after dinner. And a scoreboard most people have never checked: their morning body temperature.
Drew and Jay walk through the CM Punk transformation in detail, the recovery tools that actually move the needle versus the ones that just look good on Instagram, why "eat less, move more" is backwards for the people who are already stuck, how Jay programs cardio for busy people in five to ten minutes, and how to balance looking the part with moving like an athlete.
5 Takeaways
CM Punk was training at 5 reps in reserve with far too much volume. Jay cut the volume and the physique showed up in 6 weeks.
Jay ate 200 grams of fat a day for years without knowing it. He cut it to 50 and got the leanest he's ever been at 52.
A 95.6° morning temperature means you don't burn fat, build muscle or fight off a cold. The fix starts with orange juice before coffee.
Take your temperature before and after a brutal workout. It drops. That's why most of his clients get leaner training less and eating more.
His warm-up before the 80-pound dumbbells is three sets totaling 12 reps. Most guys do 40 and wonder why the work sets feel heavy.
Chapters
0:00 Intro: Why Half the WWE Roster Got Jacked
2:05 Minimum Effective Dose & Recovery for Banged-Up Athletes
8:16 From 147 Pounds to Coaching Pros: Jay's Background
18:44 The CM Punk Case Study: Volume, Carbs & Sleep
26:09 The Recovery Tools That Actually Move the Needle
30:42 Body Temperature: The Metabolic Scoreboard
37:00 How to Program Cardio & HIIT for Busy People
43:32 Warm-Ups, Rep Brackets & the Logbook Trap
54:55 Balancing Aesthetics & Athleticism in a Program
60:49 What Dogs Taught Jay About Presence
63:59 Building the Perfect Meal Plan
Connect with Jay:
Jay's site & coaching: https://jay.fit
Instagram: https://www.instagram.com/jayferruggia
YouTube: https://www.youtube.com/channel/UCUuDiUu00raDqT_MaNhx_Hw
Renegade Radio podcast (Apple): https://podcasts.apple.com/us/podcast/renegade-radio-with-jay-ferruggia/id853941025
Renegade Radio podcast (Spotify): https://open.spotify.com/show/0Hw50ZFA1gOfC1vQEZDI3u

Bloodwork without the doctor's visit → https://ddtmtd.co/Amplify
Third-party tested research compounds from Janus Optimize → Use code DDTSkool
Join the DDT Method Skool community → https://ddtmtd.co/skool
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Max Bertolino runs compounds himself at the doses the studies actually used, then pulls blood. In this episode he and Drew go head to head on SLU-PP-332 vs SLU-PP-915 — why the reported dosing range on 332 spans a thousandfold, what actually happens at the top of that range, and why 915 appears to do the same job at a fraction of the dose with cleaner blood work and none of the hydrazide risk.
From there it opens into the rest of the new metabolic drugs. Max breaks down the estrogen-related receptor mechanism behind the exercise mimetics — why they shift fuel selection toward fat, why they drive GLUT4 and mitochondrial density independent of training, and why the gyno panic around 332 was never pharmacologically possible. He explains ATX-304 (O-304) as a pan-AMPK activator that keeps AMPK switched on by blocking the phosphatase that turns it off, and why twelve weeks at the clinical dose did nothing measurable to his hypertrophy despite everything the AMPK-versus-mTOR crowd predicted. He covers SANA (MVD1) and the futile creatine cycle — a compound whose entire mechanism is making your body waste its own energy accomplishing nothing — along with the phase one tolerability ceiling and the creatine-loading trick one user stacked on top of it.
The back half turns to what the community already runs and gets wrong. Why the SS-31 dose everyone uses was essentially picked out of the air, an order of magnitude below the studies. Why ACE-083 grows muscle volume without a matching increase in force output. Why Masteron's reputation has no pharmacological pedigree behind it. Why Boldenone is a better Primobolan than most people will admit, and why mirabegron and albuterol are the two most overlooked compounds in fat loss.
The through-line: almost every dose and every fear this community operates on was inherited rather than measured. And the single most practical warning in the hour — stack an exercise mimetic with ATX-304 while running a deep deficit on low carbs and fasted cardio, and the compounds are not what puts you on the floor. Your diet is.

TAKEAWAYS
The dosing range on SLU-PP-332 spans a thousandfold. Only one end of it does anything.
SLU-PP-915 does the same job at roughly a seventh of the dose — and the blood work comes back cleaner.
Stack an exercise mimetic with ATX-304 and it won't be the compounds that put you on the floor. It'll be your diet.
The SS-31 dose everyone runs is 2mg. The studies showing kidney benefit start at 40.
Mirabegron is a bladder drug for old people. It burns 250 calories a day while you do nothing.

CHAPTERS
00:00 SLU-PP-332 vs SLU-PP-915: The Thousandfold Dosing Range
08:00 Why the Old Bodybuilding Compounds Are a Dead End
15:50 How Exercise Mimetics Work: ERR Activation, GLUT4 & Going Hypo
26:13 ATX-304: Pan-AMPK Activation & the Muscle-Loss Fear
33:31 Stacking ATX With SLU, MOTS-c Redundancy & the SS-31 Dose
41:16 SANA & the Futile Creatine Cycle
48:04 Myostatin Inhibition: ACE-083, Follistatin-344 & Cosmetic Muscle
56:05 Masteron, Anavar & Anadrol: What Still Earns Its Place
1:04:58 Boldenone, Beta-3 Agonism & Albuterol Over Clen
1:12:40 Where to Find Max Bertolino
FIND MAX BERTOLINO — all links verified against his own site, not taken from the transcript
Compound database & archive: https://maxpharma.wiki
YouTube: https://www.youtube.com/@MaximumPharma
Instagram: https://www.instagram.com/maxixumpharma
Instagram (backup): https://www.instagram.com/oneminpharma
TikTok: https://tiktok.com/@maximum.pharmacology
X: https://twitter.com/maximumpharma