AGEIST

Dr. Jeffrey Bland, 80, draws a sharp line between being elderly and being an elder: one has lost function and become dependent, the other stays wise, capable, and still contributing to the people around them. In this conversation, Dr. Bland explains why he's built his current company, Big Bold Health, around the immune system, since it's the one system embedded in every tissue in the body and central to how we age at the cellular level. The researcher credited with coining the term functional medicine back in 1990 shares results from an 800-person clinical trial on Himalayan Tartary Buckwheat. An ancient Chinese grain his team stumbled into almost by accident, this superfood improved cognitive performance by 27 percent in just 90 days by reprogramming the epigenetic markers on immune cells. Listeners will come away with a clearer picture of how diet, environment, and daily habits can switch specific genes on or off, and why the goal of longevity isn't just more years, but more years spent as the version of yourself still capable of contributing.
Join Us at the 2026 Super Age Games! Visit games.superage.com to learn more.
Special Thanks to Our Sponsors
Timeline Nutrition: Our favorite supplement for cell support and mitochondrial function. Listeners can now get 20% off their first Timeline purchase by using the code “AGEIST” at checkout at TimelineNutrition.com/ageist.
LMNT Electrolytes: Try the all-new Lemonade Iced Tea! Our #1 electrolyte mix for optimal hydration. Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase by using our link here. Find your favorite LMNT flavor, or share with a friend.
Key Moments
"Nature will give over her secrets."
"Elders are individuals that are wise, that are still functional, still making contributions, still being part of the productive society."
"We make over one million new immune cells every second."
Connect with Dr. Jeffrey Bland
Website
Big Bold Health 
The Disease Delusion
LinkedIn
Instagram
Facebook

Connect with AGEIST
Newsletter
Instagram
Website
LinkedIn
Click Here for the full interview transcript.
Say hi to the AGEIST team!

Paul Coletta isn’t a doctor or a scientist, which he says is exactly why he can explain proteomics in three sentences, not a confusing research paper. In this conversation, the founder of Vero Bioscience walks through what a single vial of blood can reveal about the biological age of eleven different organs. He discusses technology built in Stanford neuroscientist Tony Wyss-Coray’s lab and just spotlighted in TIME’s 2026 Longevity Leaders issue and why his own test came back showing a kidney seven years older than the rest of him–a signal his traditional labs had missed entirely. He makes the case that a single biological age number is the wrong place to stop, since averaging your organs together hides exactly the risk you’d want to catch early. Listeners will hear how Coletta has spent two years running his own N-of-1 experiment in response, adjusting his sleep, light exposure, and supplements, and what it actually takes to turn a prediction into a measurable, reversible result.
Join Us at the 2026 Super Age Games! Visit games.superage.com to learn more.

Special Thanks to Our Sponsors

BEAM Minerals: Plant-based liquid minerals for replenishing the foundational compounds your body needs to age well. Listeners can now get 20% off their first BEAM purchase by using the code “AGEIST” at checkout at BeamMinerals.com/ageist.
Timeline Nutrition: Our favorite supplement for cell support and mitochondrial function. Listeners can now get 20% off their first Timeline purchase by using the code “AGEIST” at checkout at TimelineNutrition.com/ageist.

Key Moments
“You are only as healthy as your oldest organ.”
“It’s not what’s happened to you, it’s what might happen to you if you don’t intervene.”
“Aim for the stars, hit the moon.”

Connect with Paul Coletta
Vero Bioscience
LinkedIn

Connect with AGEIST
Newsletter
Instagram
Website
LinkedIn
Click Here for the full interview transcript.
Say hi to the AGEIST team!

Nearly two decades after co-founding Fitbit and putting personal health tracking on people's wrists, James Park has turned his attention to a harder problem: the invisible mental load carried by roughly one in four American adults now caring for an aging family member. In this conversation, he explains how Luffu, his new AI-powered platform, turns scattered observations, a doctor's note, a missed pill, a change in sleep, into a shared model a family can actually act on, without requiring the aging parent to hand over their privacy in the process. 
He talks candidly about the tension at the center of caregiving technology: the caregiver wants to know everything out of anxiety, while the person receiving care simply wants the dignity of an autonomous life, and he explains how Luffu is designed to please both sides. Listeners will come away with a clearer sense of what caregiving actually costs beyond the hours logged, and what it might look like to finally put some of that mental weight into a system instead of carrying it alone.
Join Us at the 2026 Super Age Games! Visit games.superage.com to learn more.

Special Thanks to Our Sponsors
BEAM Minerals: Plant-based liquid minerals for replenishing the foundational compounds your body needs to age well. Listeners can now get 20% off their first BEAM purchase by using the code “AGEIST” at checkout at BeamMinerals.com/ageist.
LMNT Electrolytes: Try the all-new Lemonade Iced Tea! Our #1 electrolyte mix for optimal hydration. Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase by using our link here. Find your favorite LMNT flavor, or share with a friend.

Key Moments
"Your desire for reassurance doesn't automatically justify unlimited access to everything."
"There's this component of caregiving that's not just the physical work or the act of doing something."
"This is a very worthy, meaningful problem that I think affects so many people, but in some weird way is like hidden, hidden away as well."
"You always wanna start with thinking about the autonomy of the person receiving the care versus starting with the anxiety of the caregiver."

Connect with James Park
Luffu
LinkedIn
X 
Connect with AGEIST
Newsletter
Instagram
Website
LinkedIn

Click Here for the full interview transcript.
Say hi to the AGEIST team!

We're revisiting a fan favorite this week: our September 2024 conversation with Dr. Stacy Sims, the exercise physiologist behind one of the most useful ideas in women's fitness: women are not small men, and their training shouldn't be built as if they were. We're getting excited because Dr. Sims is preparing to join us at the Super Age Games this November, and can’t wait to celebrate women in sports, science, and longevity alongside her. In this episode, Dr. Sims breaks down why women over 40 need to emphasize heavy lifting and high-intensity intervals, and why perimenopause is the pivot point that changes almost everything about how a woman's body responds to exercise.
Join Us at the 2026 Super Age Games! Visit games.superage.com to learn more.
Special Thanks to Our Sponsors
Timeline Nutrition: Our favorite supplement for cell support and mitochondrial function. Listeners can now get 20% off their first Timeline purchase by using the code “AGEIST” at checkout at TimelineNutrition.com/ageist.
LMNT Electrolytes: Try the all-new Lemonade Iced Tea! Our #1 electrolyte mix for optimal hydration. Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase by using our link here. Find your favorite LMNT flavor, or share with a friend.
Key Moments
"Women don't age in a linear fashion like men do. Hormonal changes hit much earlier and more dramatically."
"For women over 40, lifting heavy isn't optional—it's essential for maintaining lean mass and bone density."
"Women are already metabolically flexible. High-intensity is where the real gains are."
Connect with Dr. Stacy Sims
Website
Instagram
Stacy’s book: Roar
Say hi to the AGEIST team!

After twenty five years as a traditional orthopedic surgeon, Dr. Elizabeth Yurth walked away from a specialty she says patches the body instead of heals it. This was a shift that eventually led her to found the Boulder Longevity Institute. In this conversation, she explains why a common knee surgery called arthroscopic debridement has been abandoned in most countries, and why cheap, decades-old lab values like creatinine and ALT are routinely misread by doctors who are misinformed on these measures. She also makes the case for treating peptides the same way we treat hormones: as naturally occurring compounds the body simply stops producing with age, not a bodybuilding shortcut or a biohacking fad. Dr. Yurth leaves listeners with a clearer, more skeptical eye for what is being marketed to them, and a working definition of healthy aging that shifts the focus from simply a lab report.

Join Us at the 2026 Super Age Games! Visit games.superage.com to learn more.

Special Thanks to Our Sponsors
BEAM Minerals: Plant-based liquid minerals for replenishing the foundational compounds your body needs to age well. Listeners can now get 20% off their first BEAM purchase by using the code "AGEIST" at checkout at BeamMinerals.com/ageist.
LMNT Electrolytes: Try the all-new Lemonade Iced Tea! Our #1 electrolyte mix for optimal hydration. Get a free 8-count Sample Pack of LMNT’s most popular drink mix flavors with any purchase by using our link here. Find your favorite LMNT flavor, or share with a friend.

Key Moments
"If all we're doing is patching people back up for them to fall apart again, what are we doing wrong?"
"They actually found that 80% of people worsened after this surgery, not just didn't get better."
"I don't need an $800 immune test to tell me. I can look at your neutrophil [to] lymphocyte ratio."

Connect with Dr. Yurth
Boulder Longevity Institute
Human Optimization Academy
Instagram
LinkedIn
Facebook
Connect with AGEIST
Newsletter
Instagram
Website
LinkedIn
Click Here for the full interview transcript.
Say hi to the AGEIST team!