Einstein's general theory of relativity, plus some reasonable assumptions about the universe and what it's made of, has a remarkable implication: that as we trace cosmic evolution into the far past, we ultimately hit a singularity of infinite density and curvature, the Big Bang. Did that really happen? Einstein's theory is classical, after all, and the world is quantum. And whose to say what assumptions are reasonable? Niayesh Afshordi and Phil Halper have written a new book, Battle of the Big Bang: The New Tales of Our Cosmic Origins, that surveys all of the mind-bending possibilities.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/05/26/316-niayesh-afshordi-and-phil-halper-on-the-big-bang-and-before/Support Mindscape on Patreon.Niayesh Afshordi received a Ph.D. in astrophysics from Princeton University. He is currently a professor of physics and astronomy at the University of Waterloo, and associate faculty in the cosmology and gravitation group at the Perimeter Institute for Theoretical Physics.Web sitePerimeter web pageWaterloo web pageGoogle scholar publicationsPhil Halper is a science communicator and a fellow of the Royal Astronomical Society. His astronomy images have been featured in major media outlets including The Washington Post, the BBC, and The Guardian, and he has published several papers in peer-reviewed journals.YouTube channel (Skydivephil)See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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315 | Branden Fitelson on the Logic and Use of Probability
Every time you see an apple spontaneously break away from a tree, it falls downward. You therefore claim that there is a law of physics: apples fall downward from trees. But how can you really know? After all, tomorrow you might see an apple that falls upward. How is science possible at all? Philosophers, as you might expect, have thought hard about this. Branden Fitelson explains how a better understanding of probability can help us decide when new evidence is actually confirming our beliefs.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/05/19/315-branden-fitelson-on-the-logic-and-use-of-probability/Support Mindscape on Patreon.Branden Fitelson received a Ph.D. in philosophy from the University of Wisconsin-Madison. He is currently Distinguished Professor of Philosophy at Northeastern University. He is a co-founder of the Formal Epistemology Workshop, and winner of the 2020 Wolfram Innovator Award.Web siteNortheastern web pagePhilPapers profileGoogle Scholar publicationsWikipediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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314 | Karen Lloyd on the Deep Underground Biosphere
There are living creatures dwelling deep below the surface of the Earth, as deep as we are able to drill. These hearty microorganisms are related to more familiar life forms on land and under water, but the operate and survive in ways that are quite different from what we're familiar with. They live off of nutrients that have penetrated from the surface, or sometimes off of pure electrons. Karen Lloyd is a scientist who has traveled around the world studying these organisms, as she explains in her new book Intraterrestrials: Discovering the Strangest Life on Earth.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/05/12/314-karen-lloyd-on-the-deep-underground-biosphere/Support Mindscape on Patreon.Karen Lloyd received a Ph.D. in marine sciences from the University of North Carolina. She is currently the Wrigley Chair in Environmental Studies and Professor of Earth Sciences at the University of Southern California. Among her awards are a Sloan Fellowship, a Simons Early Career Investigator, and a NASA Early Career Fellowship.Lab web siteUSC web pageGoogle Scholar publicationsBlueskySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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313 | Eric Topol on the Changing Face of Medicine and Aging
Medical science is advancing at an astonishing rate. Today we talk with leading expert Eric Topol about two aspects of this story. First, the use of artificial intelligence in medicine, especially in diagnostics. This is an area that is a perfect match between an important question and the capabilities of machine learning, to the point where AI can out-perform human doctors. And second, our understanding of aging and what to do about it. Eric even gives some actionable advice on how to live more healthily into our golden years.Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/05/05/episode-313-eric-topol-on-the-changing-face-of-medicine-and-aging/Support Mindscape on Patreon.Eric Topol received and M.D. from the University of Rochester. He is currently the Gary and Mary West Chair of Innovative Medicine in the Department of Translational Medicine at Scripps Research. He is also the Founder, Scripps Research Translational Institute, and Senior Consultant, Scripps Clinic, Division of Cardiovascular Diseases. Among his awards are the Hutchinson Medal from the University of Rochester and membership in the National Academy of Sciences. His books include Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again, and Super Agers: An Evidence-Based Approach to Longevity.Web siteScripps web pageGoogle Scholar publicationsWikipediaSubstackBlueskySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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AMA | May 2025
Welcome to the May 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2025/04/28/ama-may-2025/Support Mindscape on Patreon.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
About Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas
Ever wanted to know how music affects your brain, what quantum mechanics really is, or how black holes work? Do you wonder why you get emotional each time you see a certain movie, or how on earth video games are designed? Then you’ve come to the right place. Each week, Sean Carroll will host conversations with some of the most interesting thinkers in the world. From neuroscientists and engineers to authors and television producers, Sean and his guests talk about the biggest ideas in science, philosophy, culture and much more.
Listen to Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas, Making Sense with Sam Harris and many other podcasts from around the world with the radio.net app
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