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The Optispan Podcast with Matt Kaeberlein

Podcast The Optispan Podcast with Matt Kaeberlein
Optispan
Optispan is a vision for what health should be. The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. ...

Available Episodes

5 of 103
  • Crypto-Powered Science: How Blockchain & DAOs Are Reimagining Longevity Research | 97
    Subscribe to our channel: https://www.youtube.com/@optispan In this video I sit down with the COO of Molecule AG, Benji Leibowitz, to discuss how blockchain and cryptocurrency can be applied to intellectual property (IP) in biotech research, particularly in funding longevity studies. The discussion covers concepts like DAOs (Decentralized Autonomous Organizations), tokenized intellectual property, and how this model might revolutionize scientific collaboration and fundraising. 0:00 What is Molecule AG? 3:16 How Tokenized IP Works 10:30 Challenges and Trust in Crypto 25:00 Introduction to Pump.Science 39:05 The Road to Mice Experiments 42:26 Future of Pump.Science and Scaling Up 54:26 Vision for the Future Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispanpodcast/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!
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  • Peter Attia: Training, Eating & Optimizing To Live Longer & Healthier In 2025 | 96
    Subscribe to our channel: https://www.youtube.com/@optispan In this video I sit down with Dr. Peter Attia to explore strategies for improving healthspan and lifespan, focusing on practical interventions like exercise, nutrition, and emerging therapies. Topics we discuss include defining healthspan (physical, cognitive, and emotional health), the benefits of purposeful exercise, and prioritizing dietary factors (what, when, and how much to eat). Our discussion also addresses nuanced views on processed foods, alcohol, and the limitations of trendy approaches like epigenetic clocks. Other topics discussed are interventions such as hormone therapy, rapamycin, metformin, and NAD boosters, offering insights into their potential benefits and current limitations. Experimental therapies like stem cells, peptides, and hyperbaric oxygen are highlighted, emphasizing the importance of evidence-based practices. 0:00 - Introduction: Healthspan vs. Lifespan 3:51 - Exercise for Healthspan and Longevity 7:51 - Nutrition Priorities for Longevity 15:56 - Alcohol: Risks, Benefits, and Nuances 27:10 - Epigenetic Clocks and Biological Age Testing 37:08 - APOE Status and Cognitive Risk 41:25 - STEM Cells & Emerging Experimental Therapies 50:28 - Matt's Lightning Round Questions 1:12:47 - The Hallmarks of Aging Game 1:15:20 - Bonus Question Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispanpodcast/ TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!
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  • These Supplements Help Dogs Live Longer? | 95
    Subscribe to our channel: https://www.youtube.com/@optispanIn this video of Longevity this Week, Matt, Nick, and Mitchell sit down to discuss longevity supplements for pets, scientific evidence backing them, supplement industry ethics, and broader implications in the longevity field.0:00 - Introduction to Longevity Supplements for Pets0:16 - Supplement Ingredients1:30 - Evaluating Scientific Evidence4:18 - Ethical Concerns in the Supplement Industry7:20 - Potential Risks of Unproven Supplements13:00 - General Views on Health and Diet15:30 - Conclusion and Next Episode TeaserProducers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!
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  • Aging "Hotspot" Found in Brain? Hypochondriacs Don't Live as Long? | 94
    Subscribe to our channel: https://www.youtube.com/@optispanWe explore the psychological and health implications of hypochondriasis, especially in the context of biological age testing and wearables. We then delve into how anxiety and fixation on health metrics can influence behavior and potentially exacerbate health risks. This discussion transitions to a groundbreaking study on brain aging from the Allen Institute, highlighting insights from single-cell transcriptomics, particularly inflammation and neurovascular changes as drivers of aging. Finally, we discuss practical takeaways like the importance of exercise, stress management, and environmental enrichment in promoting healthy brain aging while reflecting on broader societal impacts of health-focused influencers and diagnostics.0:00 - Study on hypochondriasis and mortality risks1:20 - Biological age testing and psychological implications4:30 - Wearables and their psychological effects6:10 - Influence of biohacking on health anxieties8:10 - Concluding thoughts on diagnostics and anxiety12:30 - New study on brain aging by Allen Institute14:00 - Methodology: Single-cell transcriptomics in brain aging16:30 - Insights on inflammation and glial cells in aging19:45 - Implications for neurovascular interactions and aging22:30 - Practical advice: Sleep, stress, and physical exercise25:15 - Role of environmental enrichment in cognitive agingProducers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!
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  • Correcting the Record on Past Videos: Biological Age Tests, Full Body MRI's & More | 93
    Subscribe to our channel: https://www.youtube.com/@optispanMatt & Nick cover past episode fixes, address audience comments, and share updates about the channel and what you can expect to see from the channel moving forward into the New Year. 00:00 Intro & Setting New Years Goals 07:34 Full body MRI's11:55 DrugAge Database1:17:22 Biological Age Tests1:29:38 Matt Talking Too Much?1:32:17 Podcast Guests1:35:08 Scott CarneyProducers: Tara Mei, Nicholas ArapisVideo Editor: Jacob KeliikoaDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!
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About The Optispan Podcast with Matt Kaeberlein

Optispan is a vision for what health should be. The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good. We believe that the current practice of medicine is disease care, not health care. We believe that everyone can get closer to their own optimal healthspan.
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