Biohacking Beauty: The Anti-Aging Skincare Podcast

Most people know NAD+ as a supplement trend. But very few understand what's actually happening inside their skin cells when it runs out or what's stealing it in the first place.
By the time you're 45, you've lost half of the molecule that powers virtually every function keeping your skin young. Sadly, it only gets worse from there.
The enzyme your skin uses for DNA repair can wipe out up to 90% of what's left after a single afternoon in the sun. This isn't a slow, graceful decline. It's a collapse happening beneath the surface long before the wrinkles appear.
In this episode, we will nerd out and break down exactly why NAD+ disappears, who the thieves are, and what the science actually says about getting it back. From the sirtuin-PARP-CD38 trifecta to the zombie cell feedback loop that accelerates the drain with age, this is the most complete picture of NAD+ and skin aging we've put together to date.
We also cover the real differences between NMN, NR, and niacin, why the precursor you choose actually matters, and what to stack with it to protect your methylation pathways.
Ready to nerd out in this with us?
Let's dive in!
What's Discussed:
(4:00) The number that changes how you think about skin aging.
(6:03) What NAD+ actually does and why "rechargeable battery" undersells it.
(8:18) The three enzyme families consuming your NAD+ as a substrate.
(8:23) Sirtuins: the police of your cells and what they cost you.
(9:42) PARPs: the fire brigade and why one sunburn nearly wipes you out.
(11:16) CD38: the NAD+ Pac-Man that gets worse with age.
(15:10) The five-fold decline: what the 2012 tissue study actually found.
(16:15) CD38 and the zombie cell feedback loop driving the decline.
(19:39) What the depletion actually looks like in the mirror.
(28:04) Why NAD+ decline is reversible & supplementation deep dive.
(28:41) NMN: how it works and what the studies actually show.
(31:50) NR: the most clinically studied precursor and who it's best for.
(33:27) Niacin: the $5 option and why most people can't tolerate it.
(38:14) Why timing your NAD+ to your circadian rhythm matters.
(38:35) TMG and methylation: what to stack and the two-to-one ratio.

Learn more about NAD from our previous podcasts and videos:
Previous NAD YouTube Videos:
NAD+, Skincare Science + The Future of Skincare: https://www.youtube.com/watch?v=ZmwYLywwcsA
Biohack Your Way to Better Skin - Benefits of NAD Boosting Supplementation for Skincare & Anti-Aging: https://www.youtube.com/watch?v=KIz5MvW7X1M
Why Your NAD+ Supplement Isn't Helping Your Skin | The Truth: https://www.youtube.com/watch?v=euIj0eLt4Aw
The Science Behind NAD+, Link Between NAD+ Skin Aging, Importance of Precursors: https://www.youtube.com/watch?v=wmsUeQklYY0
The NAD+ Protocol That Could Reverse Skin Aging (Doctors Won't Tell You) | Dr. Scott Sherr: https://www.youtube.com/watch?v=iYJgVSoj_XM

Previous NAD Podcasts:
NAD 101: Unlocking The Secrets To Youthful Skin: https://podcasts.apple.com/us/podcast/nad-101-unlocking-the-secrets-to-youthful-skin/id1552026927?i=1000652231123
The Relationship Between NAD+ and Your Skin, NAD+ Depletion, Bioavailability, Precursors, Sirtuins, and More: https://podcasts.apple.com/us/podcast/22-the-relationship-between-nad-and-your-skin/id1552026927?i=1000568088462
The Science Behind NAD+, the Link Between NAD+ and Skin Aging, and the Importance of Precursors: https://podcasts.apple.com/us/podcast/the-science-behind-nad-the-link-between-nad-and/id1552026927?i=1000615122098
Ben Azadi: How NAD+ Helps Reverse Aging + Skin Problems Connected to Deeper Health Issues: https://podcasts.apple.com/us/podcast/ben-azadi-how-nad-helps-reverse-aging-skin-problems/id1552026927?i=1000662495945
Turn Back the Clock: NAD and Skin Biohacking: https://podcasts.apple.com/us/podcast/turn-back-the-clock-nad-and-skin-biohacking/id1552026927?i=1000681105344

Research Studies Mentioned:
Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042357
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30225-7
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages: https://www.nature.com/articles/s42255-020-00305-3
Enhanced SIRT1 Activity Mitigates UVB-Induced Senescence in Dermal Fibroblasts: https://pubmed.ncbi.nlm.nih.gov/39401943/
Slc12a8 is a nicotinamide mononucleotide transporter: https://www.nature.com/articles/s42255-018-0009-4
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: https://link.springer.com/article/10.1007/s11357-022-00705-1
Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation: https://www.science.org/doi/10.1126/sciadv.adl5154
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults: https://www.nature.com/articles/s41467-018-03421-7

Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.com
Instagram: @young_goose_skincare
Head to younggoose.com/products/youth-body-cream for 20% off
Body Cream: Head to younggoose.com/products/youth-body-cream for 20% off

Most people treat their skin like a surface problem. But almost every persistent skin issue, from rosacea to eczema to accelerated aging, has something deeper driving it.
That deeper driver is almost always the gut, the liver, or a backed-up detox pathway. We at Young Goose, always believe that skincare is whole body care and we want our community to identify the deeper causes of skin issues that products alone can’t fix.
In this episode, functional nutrition practitioner Dani Conway joins us to break down why the skin is not the origin of the problem but the exit sign. When the body cannot eliminate toxins efficiently, they take the path of least resistance. For a lot of women, that path is the skin on their faces.
Dani brings nearly 20 years of clinical practice to this conversation, along with a sharp, evidence-grounded perspective on why fixing hormones first is often the wrong starting point and what to address instead.
We go deeper into this in the latest episode of Biohacking Beauty: The Anti-Aging Skincare Podcast. We also cover how to deal with food sensitivities, common misconceptions around hormones and blood sugar testing, and the use of GLP-1 and peptide use.
Let’s dive in!
What's Discussed:
(0:57) How poor detoxification shows up on the skin.
(2:09) The foundational actions to support detox.
(5:44) The lymphatic system explained.
(6:33) Why Dani stopped addressing hormones first.
(8:01) Microplastics, endocrine disruptors, and chemicals women apply to their skin.
(11:40) The gut-skin axis: How gut symptoms always end up on your face.
(13:55) NAD, CD38, and why a bacterial infection in your gut affects cell energy.
(16:59) Why peptides and NAD supplements don't work if the foundation isn't dialed in first.
(21:26) Can you actually fix hormones or just manage them?
(25:12) Real-world food sensitivity examples and how to figure out your personal triggers. (29:41) How to run an elimination diet correctly.
(34:39) The big picture nobody talks about: it's not the food, it's the immune system.
(36:06) The new science on acne: The bacteria and immune system response.
(38:06) Hot take: Why immune optimization is the next mitochondria.
(39:49) CGMs and skin aging: Why Dani actually pulls clients back from data obsession.
(42:09) Fasting insulin ranges: Why the lab's "normal" range is dangerously wide.
(43:35) The role of GLP-1s and how to use them as a therapy instead of a crutch.
(45:12) Dani's hot take on berberine and leptin resistance.
Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.com
Instagram: @young_goose_skincare

Find more from Dani Conway:
Instagram: @DaniConwayOfficial
Website: https://nutritionthenaturalway.com/
The Wellness Collective: https://nutritionthenaturalway.com/drop-the-weight-shred-the-fat/
Weight Loss Accelerator Program: https://go.nutritionthenaturalway.com/wla
Free Complimentary Guide: https://go.nutritionthenaturalway.com/hhh

Most people think that the stinging feeling, redness or tightness are always good signs of skin detoxification. Tricky enough, it can look like ‘glass skin’ or skin renewal. However, almost always the temporary tight and bright skin is a skin barrier issue in disguise.
Skin barrier damage is one of the most misread signals in skincare. It looks like purging but it is actually your skin telling you it has been pushed past its limit.
It’s easy to think there’s no damage at all because overexfoliation can temporarily give a satisfying baby skin at the cost of long-term skin wellness.
One of the best ways to distinguish normal skin stimulation versus barrier damage is to understand your skin biology. As Anastasia always says, "We're not chasing a 10-day glow. We're chasing a 10-year outcome."
We go deeper into this in the latest episode of Biohacking Beauty: The Anti-Aging Skincare Podcast. We also cover what real skin barrier repair should feel like, the pillars of skin wellness, and how to listen better to your skin to train it to become more resilient.
Resources mentioned:
Barrier Protocol: https://www.younggoose.com/pages/barrier-protocol
What's Discussed:
(04:20-05:11) Why a weak skin barrier makes every other skincare step stop working
(05:11-06:16) The four signs of barrier damage that looks like progress
(06:16-08:29) What is a skin barrier and what happens when the lipid ratio breaks down
(08:29-10:10) How barrier disruption can disguise as purging
(10:10-13:00) A case study of laser-induced barrier damage and the cycle of over-treatment
(13:00-15:11) The three pillars of skin wellness: performance, resilience, and longevity
(15:11-16:52) What your skin should be able to do before you add any heavy stimulation
(16:52-18:30) The three-step barrier reset protocol
(18:30-20:30) Morning versus nighttime barrier: defense vs. repair
(20:30-25:09) The truth about exfoliation culture and the glass skin trend
(25:09-27:00) How to build an exfoliation schedule that works for your skin type
Find more from Young Goose:
VAMPIRE EXOSOMES → Professional Exosome Serum for Regeneration and Post-Treatment Recovery
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.com
Instagram: @young_goose_skincare

Did you know that the most powerful anti-aging protocol isn't about how long you sleep? It's about when. Getting eight hours of sleep for skincare feels like a tough feat to achieve especially when life gets in the way.
By understanding how your skin begins its optimal repair time, it’s still possible to achieve the best skin results without the guilt of not sleeping enough.
In our quest in finding the best skincare ingredient for our products, we discovered that hours of sleep do matter, but best skin results happen by following the skin’s optimal program sequences for deep repair.
We go deeper into this in the latest episode of Biohacking Beauty: The Anti-Aging Skincare Podcast. We also cover how melatonin onset, circadian rhythm, growth hormones, and inflammation play a huge role in giving your skin the environment it needs to do its best work.
What's Discussed:
(1:54-5:09) Why sleep timing matters more than sleep hours for skin repair
(07:01-15:19) The three repair windows your skin depends on every night: melatonin onset, growth hormone pulse, and barrier recovery
(05:09-5:55) Why dull skin, slow healing, and crepey eyes are often a timing problem — not a product problem
(13:28-17:10) How to build a recovery-first nighttime routine before adding any stimulation
(37:47-40:47) The silk vs. cotton pillowcase: Which fabric choice is part of your skincare
(43:29-47:36) Supplements that support skin repair at night
(17:17-17:30) Red light therapy as the only exception to the no-stacking rule

Resources mentioned:
Sleep protocol: https://www.younggoose.com/pages/sleep-protocol
Episode with Anastasia (BeautyFascia): https://podcasts.apple.com/us/podcast/anastasia-beauty-fascia-facial-fascia-and-massage
Episode on Face Taping with Olga from Natural Face Bible: https://podcasts.apple.com/us/podcast/real-japanese-face-taping-explained-with-olga
Find more from Young Goose:
The Elastin Action Protocol → Engineered for Skin Navigating Elasticity Change
The Winter Skin Protocol → Build for How Skin Actually Behaves in Winter
VAMPIRE EXOSOMES → Professional Exosome Serum for Regeneration and Post-Treatment Recovery
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.com
Instagram: @young_goose_skincare

Molecular hydrogen is often described as a selective antioxidant, but that framing is incomplete. In this episode, we explore hydrogen as a mitochondrial hormetic signal that can influence redox balance, inflammatory regulation, and adaptive stress pathways. The key distinction is that delivery route changes mechanism. Oral, inhaled, and topical hydrogen act differently in the body, with different kinetics, tissue distribution, and biological implications.
We dive deeper into this in the Biohacking Beauty Podcast with Alex Tarnava. We discuss why topical hydrogen is gaining attention for skin outcomes, how gut-mediated signaling may drive systemic effects, and why interpreting evidence requires understanding study design, delivery method, and real-world product variability.
WHAT’S DISCUSSED:
(04:52) Why hydrogen is not a traditional antioxidant and what that actually means biologically
(06:17) How different delivery routes change tissue targeting and systemic signaling
(10:09) Why skin aging and inflammatory conditions behave more like a systems problem than a single pathway
(15:10) How mild oxidative stress can activate endogenous antioxidant production
(16:05) The hidden risk of reductive stress from excessive antioxidant use
(17:59) Why inflammation must be regulated rather than suppressed for long-term tissue repair
(28:52) The gut-driven mechanisms that may influence visible skin outcomes
(29:42) How corporate-owned research and investigator-led studies shape the hydrogen evidence landscape
(37:25) Why exaggerated longevity claims distort innovation and erode trust
(50:49) The growing issue of counterfeit hydrogen products and what it signals about market maturity
Find more from Young Goose:
The Elastin Action Protocol → Engineered for Skin Navigating Elasticity Change
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.com
Instagram: @young_goose_skincare

Find more from Alex Tarnava:
Website: https://hydrogenwatertablets.com
https://alextarnava.com
Instagram: https://www.instagram.com/alextarnava