Clinical Pharmacology Podcast with Nathan Teuscher
Nathan Teuscher
I discuss clinical pharmacology and pharmacometrics topics from the perspective of drug development scientists. I share my expertise and knowledge about designi...
In this episode I share a couple short clips from my conversation with Chad Briscoe and Greg Austin from BioTalk Unzipped (www.biotalkunzipped.com). We chat about a variety of topics including artificial intelligence and challenges with cell therapy development. You can hear the entire conversation on the BioTalk Unizipped podcast or YouTube channel in January. For now, enjoy these clips from the upcoming show!
Links discussed in the show:
BioTalk Unzipped main page
BioTalk Unzipped YouTube channel
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13:53
Toxicokinetics (Ep. 39)
In this episode I discuss toxicokinetic analysis. This is the analysis of exposure data to support animal toxicology studies. I review the purpose of toxicology studies and how exposure metrics are used. Then I discuss different blood sampling schemes, and how to calculate exposure parameters for both full profiles and mean profiles.
Links discussed in the show:
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Copyright Teuscher Solutions LLC
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19:03
Steady State (Ep. 38)
This episode is a discussion of steady state pharmacokinetics. Steady state occurs when the amount of drug input is equivalent to the amount of drug elimination in a dosing interval. I discuss some key PK parameters at steady state and how to use them. I also discuss different methods of confirming that you have reached steady state.
Links discussed in the show:
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Copyright Teuscher Solutions LLC
All Rights Reserved
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16:27
Dose Proportionality (Ep. 37)
In this episode I talk about dose proportionality, which is a surrogate for determining if we have linear clearance across a range of dose levels. I discuss 3 different methods that people use to determine dose proportionality along with a recommendation to use the power model method.
Links discussed in the show:
Power model method
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16:58
Covariate Search Methods (Ep. 36)
This episode is a discussion of covariate search methods. I give definitions of covariates and predictors, and then I describe 3 different covariate search methods. For each method I describe the pros and cons associated with each one, including bias and time limitations.
Links discussed in the show:
Evaluation of the Boruta method for covariate selection
You can connect with me on LinkedIn and send me a message
Send me a message
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Copyright Teuscher Solutions LLC
All Rights Reserved
About Clinical Pharmacology Podcast with Nathan Teuscher
I discuss clinical pharmacology and pharmacometrics topics from the perspective of drug development scientists. I share my expertise and knowledge about designing and conducting clinical pharmacology studies and discuss how to analyze the data using the most effective approaches. I draw from my experience of over 20 years working in drug development organizations and consultancies.
South Africa