The Real Science of Sport Podcast

Everywhere you look people are talking about peptides. But what exactly are they, how do they work and how safe are they for human consumption? Mike and Ross review the evidence, discuss the politics that continue to muddy the waters around peptide efficacy and regulation, and examine the dangers of using untested peptides. The team also look into the role of the popular GLP-1's that have revolutionised diabetes and weight loss and the controversial BPC-17 peptide, touted as a miracle treatment for tissue repair.

Links
The Undark article that describes the history of BPC157
More on the FDA and the complex regulation of peptides
A report on one of the FDA decisions about peptides - in this case BPC157 and KPV
A paper from the discoverer of BPC157, who has published more than three-quarters of the research on it
The human safety study on BPC157, with its two participants
Systematic review of BPC157 evidence, suggesting promise but caution
A well researched article by Dr Eric Topol raising concerns about safety and regulatory decisions
Example of a public warning from a regulatory body, this one from South Africa
Follow the money - Fortune 500 piece on why deregulation could create a multibillion dollar market

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Become a Supporter of The Science of Sport for about the price of a coffee, or a gel, and help us keep the lights on, and Gareth's candle burning! Plus, you'll get ad free listening, a weekly Applied show, and a community that argues better than the internet does!

Show notes

On the show today, the physiology behind the best women's Grand Tour we can remember, and a doping ban that fits a pattern we have seen many times before.

(00:01:00) The Tour de France Femmes was, we think, the best Grand Tour either of us has watched in years, and we explore the nine stages of unpredictable racing that had us intrigued, even if the record will show that Demi Vollering won four of them.
(00:05:56) Kasia Niewiadoma's ride on Mont Ventoux, at somewhere between 5.3 and 5.6 W/kg for the climb, is arguably the greatest climbing performance in the history of women's cycling, and we place it against the published power duration curves to show just how far outside the 90th percentile it sits.
(00:17:19) Niewiadoma also posted 9.9 W/kg for 86 seconds, and from that single Strava screenshot we work out her FTP and her W', the anaerobic "battery", which lets us answer the question everyone argued about, namely whether being blocked into that corner actually cost her time to rival Vollering. We think the answer is unequivocally yes, and the maths and the principle of pacing explains why.
(00:25:50) Praise for Puck Pieterse, sympathy for Marlen Reusser and Pauline Ferrand-Prévot, and a wonder about the 'mature' podium, and the prospect of a handover to the next generation in good time, just not 'our time'
(00:41:41) The World U20 Championships, where a 17 year old ran 7:28 solo for 3000m, Tate Taylor doubled up in 9.94 and 19.83, and the ever-turning carousel of youth talent that is sometimes derailed by injury and sometimes deposed by the next young phenom
(00:45:46) Jakob Ingebrigtsen returns and wins the European 5000m title in 13:16, off a slow race that played into his hands, and he explains, correctly, that a 5000m is not a test of speed but of how much speed you have left. He also promises he'll be "astonishingly a lot better" next time.
(00:52:32) Jonah Koech gets a three year ban after an adverse passport finding. We explain how the biological passport actually works, why two suspicious samples means the values must have been wildly out of the norm, and why his 3.2% improvement should have invited scepticism long before the blood results did. Performance is not proof, but pattern recognition lives on, with this its latest illustration.
(01:07:46) The WNBA has no eligibility policy, so two former NBA players have declared for the women's draft to prove the point. We discuss why choosing not to decide is itself a decision, how people are choosing to pretend a problem doesn't exist (or that it doesn't matter if it does), and contrast this with the WTA who have implemented screening for eligibility, and just gotten on with it
(01:15:29) And finally, the origins of the steeplechase, which begins with two blokes, an Irish pub, a wager, and two church steeples. Plus a nutritionist on social media who watched 96 seconds and decided we had lost all credibility.

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Show notes

Josh Kerr, the Commonwealth Games, a stitch explained, the Tour de France Femmes, and yet another South African schoolboy rugby doping ban. In today's show:

(00:00:38) We joked before Glasgow that this might be the last Commonwealth Games we ever see, and we were wrong. They survived in a cut-down, ten sport form, with India in 2030 and interest from Nigeria and New Zealand for 2034. We debate whether a smaller, cheaper games is actually the point rather than the problem, and what it means that the BBC's sub-one-million-pound bid was rejected, leaving Josh Kerr's mile watched by 200,000 people when Eilish McColgan's 10,000m in 2022 drew six million.
(00:02:37) The performances, including Emmanuel Eseme of Cameroon running 9.83 in apocalyptic rain, three women under 11 seconds, and Josh Kerr's utterly dominant 3:54 mile off a jogged first kilometre. With the fastest mile in history relative to his peers and a devastating kick, how does anyone actually beat him now, and will the 1500m world record follow? Kerr says he is flying a little close to the sun, and we explain why staying in world record shape is like sitting in the death zone on Everest.
(00:24:13) Laura Muir crossed the line 16th and collapsed after a stitch at 3km, so what actually causes one? We go through exercise related transient abdominal pain, the old diaphragmatic ischaemia theory, the newer parietal peritoneum irritation explanation, why shoulder tip pain is referred pain, and the risk factors including drinking before you run, being younger, being female, and having weaker trunk muscles.
(00:33:56) Ingebrigtsen returns at the Euros over 5000m off two disrupted seasons and Achilles surgery, and we're not sure it'll be the comeback people hope for.
(00:44:52) The Tour de France Femmes is brewing into a genuinely great race, with time gaps after the time-trial necessitating attacking racing as the Tour heads into its hilly and mountain stages. Niewiadoma and Ferrand-Prevot in particular need to claw back big time, while Reuser defends and Vollering waits ominously in pole-position. Instead the world's media is writing about padded bras. Why does cycling always shoot itself in the foot, and why is it a headline for the women when it was an incidental for the men?
(00:47:40) Tadej Pogačar's estimated VO2max of over 100 is doing the rounds, using exactly the methods Ross was hammered for using on Contador and Froome fifteen years ago. We explain the modelling, why assumptions can spit out anything between 85 and 101, and what that means for comparing Pogačar to Pantani on Alpe d'Huez.
(00:55:56) The full Markéta Vondroušová decision is out, and it reads very differently to the version that had tennis players outraged. Plus a hard look at South African schools rugby, where Deon Botes is the third schoolboy banned in months, this time for a supplement his father allegedly bought for cash from a stranger outside a pharmacy with "ultimate test booster" on the box.
(01:12:47) Jannik Sinner walks away from a potential clean sweep of the Masters events to play less tennis before the US Open, while Carlos Alcaraz withdraws from Cincinnati and extends a wrist injury layoff that has now cost him May, June, July, and half of August. Two very different answers to the same question, and one that echoes Josh Kerr's approach to racing.
(01:15:00) And finally, an update on Anna's ride around Australia. Nine days, 976km, 7,940m of climbing, one chain change, and three magpie attacks.
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Ross Hemingway, OBE, is a Sport & Exercise Medicine Practitioner at the Commando Training Centre for the Royal Marines. His clinical expertise centres on exertional collapse, in particular the prevention, acute management, and rehabilitation of exertional heat illness (EHI) in elite, amateur, and tactical athletes, and is recognised as a UK national expert in this field. Hemingway is also a member of the UK Heat Illness Advisory Group and a contributing author to the Faculty of Pre-Hospital Care’s (FPHC) UK consensus statement on the management of Exertional Heat Illness.
In this interview, Hemingway breaks down the theory of heat illness, how it happens, prevalence, and the best ways of dealing with EHI during exercise.
Alongside his clinical practice, he is also the founder of Nereus Medical Ltd and inventor of the patented I-CWIK, a lightweight, robust and clinically proven system developed to provide effective cold-water immersion of heat stroke casualties in the pre-hospital and hospital environment.

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SHOW NOTES
The EHI Consensus Statement website

The Full EHI Article, of which Ross is lead author

One of the studies Ross alluded to, this one from the World Champs in Doha

Another paper he mentioned, discussing athlete management ahead of the Olympic Games

The baboon model for heatstroke discussed on the show

We published a study years back documenting some heatstrokes in SA endurance events

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Become a Supporter of The Real Science of Sport, and for the price of a coffee, or a gel, you get a bonus Applied episode every week, ad-free shows, and the best cycling and running community going over on Discourse.

Show notes

This week we recap Tadej Pogačar's record-breaking Tour de France, and then get into the meat of it: why anti-doping leans so heavily on investigation and targeted testing, with insights from our interview with Brett Clothier, head of athletics' Athletics Integrity Unit.

(02:24) Tadej Pogačar wins a fifth Tour de France in what Ross reckons is the most dominant display he has seen in any sport, and we dig into the numbers behind it, including an estimated 7 W/kg on Alpe d'Huez that obliterates Pantani's old mark, why the yellow jersey was effectively settled by stage six, and why the racing everywhere else still made it a decent watch.
(13:55) The weight-loss double standard. Remco Evenepoel reportedly dropped around nine pounds for the Tour with barely a murmur, while Pauline Ferrand-Prévot's weight loss dominated the coverage last year. We ask why the reaction differs by sex, and where the line sits between periodised, medically supervised leanness and a genuine eating-disorder risk.
(19:42) That Montmartre finale, with Van der Poel and Pogačar breaking clear on the last climb, van der Poel's heroic's to hold off the chasing pack, and Jasper Philipsen's remarkable judgement to "win" by not winning against his team-mate. Plus, we ponder whether the GC should really be neutralised so early on the final day? We say let them race.
(32:37) The headline this week: why testing alone rarely catches the big fish, and why investigation and targeted testing do. Prompted by the furore over 2am and 5am testing at the Tour, we hear from Brett Clothier of the Athletics Integrity Unit, and explain the biological passport, the micro-dosing of EPO, fast-clearance methods, gene-doping fears, and why a genuinely "transparent" statement about a target test is close to impossible without prejudicing everyone involved.
(46:26) A look ahead to the women's Tour de France, the contenders including Vollering, Blasi, Niewiadoma, Ferrand-Prévot and Reusser. With storylines galore, it features the return of a time trial, and French TV figures showing the women's race is closer to the men's than you might expect.
(51:48) Are the Commonwealth Games in Glasgow still worth watching without the stars? Gareth is won over by the weightlifting, and we ask whether you really need the very best in the world to enjoy sport.
(58:49) The Ultimate Championship, athletics' new 10 million dollar, three-night, TV-first format, complete with a black infield, real-time win probabilities, Mondo Duplantis on stadium DJ duty, and no country quotas. We react, and Ross pitches what he would add to the broadcast
(64:16) Josh Kerr reveals how the pacing lights were slowed over the final 100 metres of his mile record to create the illusion he was beating them. Clever theatre, or are we being deceived?
(67:00) And finally, Discourse member Ana sets off on a 15,000km "big lap" of Australia on her gravel bike. We wish her luck, and start plotting the data she should share with our listener community!

Links

This is the ITA statement during the Tour - it's really all they can say and expecting more is a day dream!
The article on gene doping - speculative and sounds like sci-fi, but might it be happening
The paper on micro-dosing and detection challenges
Plugge on how the tests brought doping back to cycling
Preview of the TDF for Women
Details on the World Athletics Ultimate Championships
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