From the Spectrum: Finding Superpowers with Autism

• Tryptophan, Microtubulus, & Mitosis

  This episode explores the critical role of tryptophan, an aromatic amino acid, in forming tubulin—the key protein building microtubules, which act as cellular "train tracks" for structure and movement. We delve into how microtubules drive mitosis, the process of cell division essential for growth and repair, and discuss tryptophan’s unique biochemical significance, including its single codon (UGG) and contributions to DNA methylation.We connect these cellular mechanisms to Autism, examining how microtubule disruptions may affect neuron proliferation and migration during prenatal development, potentially leading to sensory processing issues and altered connectivity. The episode highlights the intricate dance of cells in neural tube formation and emphasizes the need for deeper research into these upstream processes to uncover Autism’s developmental roots.YT video of tryptophan and microtubules https://youtu.be/AY6GmS_AePk?si=K_ZTy5RjLGkm1hGdInner Cell Life video https://youtu.be/RrS2uROUjK4?si=DCHs927yteOZ00dWSee Stuart Hameroff, Martin Picard, Michael Levin, Jack Kruseuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139use "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 Daylight Computer Company, use "autism" for $25 discount04:22 tryptophan, aromatic amino acid, microtubules, mitosis; human biology, autism04:44 tryptophan, UGG codon, methionine, SAM, MTHFR, folate, DNA methylation; upstream biology, RNA, DNA06:04 microtubules, train tracks, mitosis, cell division, spindle, DNA separation; skin repair06:55 tryptophan, tubulin, microtubules, mitosis, intracellular transport, cell shape; Autism research, upstream processes9:25 Chroma Light Devices- Lights Designed for Humans, use "autism" for 10% discount12:27 tryptophan fluorescence, mitosis, prophase, prometaphase, metaphase, anaphase, telophase, cytokinesis; microtubules, chromosome movement, cell division, tissue repair15:58 mitosis, neural tube, embryonic development, neuron proliferation, migration; Autism, brain size, connectivity20:33 sensory processing, hyperconnectivity, synaptic pruning, microtubules; Autism, sensory sensitivities, cortical connections25:06 excitation-inhibition imbalance, microtubules, environmental toxins, light exposure, fertilization, blastocyst; Autism, prenatal development, cell polarity31:09 microtubules, neural tube, gastrulation, neurogenesis, synaptogenesis, ectoderm, mesoderm, endoderm; Autism, cell migration,37:18 outro, reviewsX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: [email protected]

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• (Re-Release) The Roles of Oxytocin & Vasopressin in the Autistic Phenotype

  In this episode, we explore Oxytocin and Vasopressin's vast roles in Human Biology. We time travel to cover the evolution of the two molecules and learn about their functions with developing and socializing. Oxytocin and Vasopressin are dynamic molecules whereby they are Peptides and Hormones. In addition, we cover previously discussed brain regions and how the molecules work alongside key Neuromodulators like Serotonin and Dopamine.Social Reward https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214365/Social Reward Requires Oxytocin and Serotonin in Nucleus Accumbens (Parvo Path) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091761/Magnocellular and Parvocellular social Information Processing https://www.cell.com/neuron/fulltext/S0896-6273(20)30770-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320307704%3Fshowall%3DtrueMagnocellular and Parvocellular https://onlinelibrary.wiley.com/doi/10.1111/jne.12284Meta-Analysis of Intranasal https://pubmed.ncbi.nlm.nih.gov/?term=intranasal+oxytocin+autism&sort=pubdate&filter=pubt.meta-analysishttps://pubmed.ncbi.nlm.nih.gov/33400920/Intranasal Review https://pubmed.ncbi.nlm.nih.gov/38579916/(0:00) Intro; Oxytocin and Vasopressin; Episode Objectives(2:46) Oxytocin and Vasopressin; 700 million year time travel (Phylogeny)(4:12) Peptides and Hormones; Modes of Transmission- Endocrine, Paracrine, Synaptic(6:35) Proteins and Peptides; Amino Acids and Aromatic Amino Acids and Light(8:58) Magnocellular and Parvocellular(12:33) Roles of Oxytocin and Vasopressin and connections to various Brain Regions(22:20) Scientific Literatures(27:12) Oxytocin and Serotonin; 1) Reward Processing, 2) Fear Response, 3) Social-Emotional Processing(30:07) Oxytocin and Dopamine(31:08) Dopamine Receptors(31:37) GABA(33:57) Intranasal Oxytocin(36:08) Take aways from Intranasal Literature(37:24) Biggest Take Away (Magnocellular versus Parvocellular and Intranasal Administration)email: [email protected]

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  39:16
• Autism, Circadian Rhythms & Protocols

  In this episode, we navigate the fascinating world of circadian rhythms and their profound impact on our health. We cover essential biology and protocols for human health, Autism or not. We will discuss how these natural cycles of light and dark regulate our biology, from hormone production to mood and cellular function, and why disruptions—particularly from artificial light—are a growing concern in modern society. Highlighting the role of melanopsin, a blue light-absorbing protein discovered as recently as 1998, we explore how exposure to LED and tech light can throw off our internal clocks, a challenge especially relevant for those with autism who often struggle with circadian rhythm issues.Modern life has two problems: 1) removing ourselves from the full sun spectrum and 2) extending the day with artificial light at night. This, in large part, explains the origins of Autism: 1) a lack of biological energy (energy from the full sun spectrum during development- remember the episodes on neurulation, embryo and womb) and 2) improper clock-timing in our biology (in large part, this is why the gastrointestinal comorbid problem is heavily involved with Autism).We also introduce actionable protocols to reset and maintain a healthy circadian rhythm, whether you're autistic or not, emphasizing the critical role of sunlight at different times of day—morning, midday, and evening. We will discuss innovative solutions like the Daylight Computer, a blue light-free, flicker-free device designed with sensory-sensitive users in mind, and Chroma light devices that harness specific wavelengths to enhance well-being. Alongside these insights, we touch on historical and environmental factors, including a thought-provoking comparison to the Amish lifestyle, to underscore how our modern world might be influencing Autism rates and overall health.use "autism" for $25 off athttps://daylightcomputer.com?sca_ref=8231379.3e0N25Wg3wuse "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 Circadian rhythms introduced; blue light’s impact via melanopsin and Daylight Computer’s benefits.00:42 Daylight Computer Company5:00 Blue light’s harm, autism energy deficits, and artificial vs. natural light comparison.08:01 Melanopsin’s role, modern light’s disruption, and historical autism link to artificial light.12:01 Amish lifestyle comparison and modern environments’ effect on autism rates.16:01 Morning sunlight protocol for circadian reset via SCN and melatonin timing.20:01 Morning sun primacy; Non-Negotiable 21:23 Chroma light devices for health24:33 Midday sun / UV light for longevity, evening sun’s role, and ranking sunlight importance.28:01 Nighttime light management: avoid overhead lights, prefer candles/red lights, ensure dark sleep.32:01 Maternal health benefits, reviews/ratings, and social media/podcast engagementX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: [email protected]

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  33:33
• Dr. Richard Frye, MD, PhD: All about Leucovorin & Benefits for the Autistic Phenotype

  For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters.Dr. Frye shares many figures during the conversation so the listener can follow along.Dr. Richard Frye https://drfryemdphd.comRossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenterNeurological Health Foundation https://neurologicalhealth.orgHealthy Child Guide https://neurologicalhealth.org/the-guide-5/Daylight Computer Company https://daylightcomputer.com?sca_ref=8231379.3e0N25Wg3wuse "autism" in the discount code for $25 coupon.This is the future of tech.Chroma Light Therapy https://getchroma.co/?ref=autismuse "autism" for a 10% discount,0:00 Dr. Richard Frye0:58 Daylight Computer Company5:17 Chroma Light Devices8:27 History of Leucovorin; low risk, high reward; Folate Receptor Alpha (FRa)10:25 Blood Brain Barrier; Folate; CSF (cerebral spinal fluid)14:04 DNA, RNA; MTHFR (Methylenetetrahydrofolate reductase)17:34 Cerebral Folate deficiency; BH4, Placenta & Womb23:35 Folate deficiency & Autism26:21 Clinical Studies & Data29:28 Folate & Mitochondria; Cerebral Folate Antibodies; White Matter Findings (!)34:45 Cerebral Folate deficiency & Ranges; Autistic Phenotypes: Language, Communication, & Behaviors40:45 Language & Communication; Self-Injurious Behaviors; Hyperactivity, Agitation; Treatment duration42:53 Folate Autoantibodies & Maternal Health & Markers45:30 Studies & Behavioral outcomes; inflammation & thyroid findings46:58 Neural development; Language connections, white matter tracts & distal connections48:53 Leucovorin for different severity/levels of Autism; Spinal Bifida51:08 Preparing for pregnancy53:50 Transgenerational aspects of Folate Autoantibodies Research; Prenatal Care & Awareness59:32 Guidance & SupportX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: [email protected]

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• Nicole Rincon, PA-C: Various Biomarkers including Gastrointestinal Issues & Autism

  Nicole Rincon https://www.nicolerincon.comNicole's X https://x.com/NicoleRinconPARossignol Clinic https://rossignolmedicalcenter.comTACA Info: https://tacanow.org/wp-content/uploads/2019/10/F-H-2-Nicole-Rincon-Beginning-Biomed.pdfTACA Talks: https://www.nicolerincon.com/videosPublications https://rossignolmedicalcenter.com/articles-publications/#published-2024-2-articlesNicole Episode 1 https://www.youtube.com/watch?v=BBkdgwVfcZINicole Episode 2 https://www.youtube.com/watch?v=auLReV0DHkQDaylight Computer Company https://daylightcomputer.comuse "autism" in the discount code for $25 coupon.This is the future of tech.Chroma Light Therapy https://getchroma.couse "autism" for a 10% discount,***THIS IS NOT MEDICAL ADVICE***0:00 Nicole Rincon1:10 Daylight Computer Company; DC-15:33 Pre-pregnancy checks; Vitamin D8:37 MTHFR, Folate; Mitochondria; CPR, ESR, Inflammation11:12 GI; CSA; Bacteria, Fungus, Parasites, Calprotectin; Zonalin; MS & Proteus Mirabilis13:06 Organic Acid Test (OAT); Clostridia15:24 MTHFR; C677, 1298; Folinic Acid19:02 Folate's role in pregnancy and development; Critical info about types and duration22:35 Cholesterol; Maternal & Child; Speech & Communication25:06 Telepathy; Autism Rates26:40 Dysbiosis; PCOS29:30 Cholesterol ranges & symptoms; mood, irritability, cognition, aggression; Cortisol & Hormones37:02 Dysbiosis symptoms; Self-Injurious, Posturing41:08 Identifying symptoms in Non-Verbal; Self-Injurious45:08 Importance of Gut Health & Checks; Vitamin D, Electrical Efficiency & Biological Energy48:17 Autistics and pale skin; too many are pale; supplementing Vitamin D, K2; Brands51:00 Proprietary blends warning; abbreviated doses; Fungal overgrowth, Yeast55:49 "Binders;" Magnesium61:00 Fungal Overgrowth & Autism; OAT, Clostridia, C. diff, aggression, self-injurious; Antibiotics & Probiotics1:05:42 Telepathy Tapes, Autism, Water (Cytochrome C Oxidase), Coherence; Luc Montagier NOT Emilio Del Giudice; Distal Connections via Water and NOT axons; OutroX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: [email protected]

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  1:18:05

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