PodcastsTechnologyY Combinator Startup Podcast

Y Combinator Startup Podcast

Y Combinator
Y Combinator Startup Podcast
Latest episode

318 episodes

  • Y Combinator Startup Podcast

    Why Domain Experts Are Winning In The Age Of AI

    2026/06/19 | 42 mins.
    Bryant Chou co-founded Webflow, which today powers around 1% of all websites on the internet. Now he's back in the current YC batch with Ploy, an AI-powered website and marketing platform that doesn't just build your site — it connects to your analytics, CRM, and search console to optimize your marketing while you sleep. In this episode of the Lightcone he explains how he built Ploy to be “anti slop,” how building today compares to his first startup, and why founders with domain expertise are making a comeback.Chapters:00:00 — What Experience Gives You in the Age of AI00:38 — Meet Bryant Chou, Co-Founder of Webflow01:22 — His New Startup Ploy02:47 — Rebuilding the Posterous website From 200803:27 — Rebuilding the Scribd website From 200705:04 — Rebuilding the Auctomatic website From 200706:19 — Rebuilding the Escher Reality website From 201707:11 — 12% of the YC Batch Uses Ploy08:26 — The D&D Theory of Founder Skills10:05 — Democratizing Marketing and Growth10:50 — Live Demo: The Design Slurper13:21 — Your Website Should Work for You While You Sleep14:26 — Integrations, Analytics, and the Marketing Brain17:27 — Ploy's Anti-Slop Engine: 3,500 Curated Design Prompts20:05 — The Andy Warhol Theory of AI22:35 — Webflow Origin Story24:26 — Building in a Competitive Market Then vs. Now26:01 — First Three Months: Webflow 2013 vs. Ploy 202527:17 — What Experience Teaches You That Models Can't28:51 — Will Better Models Kill Products Like Ploy?30:32 — The Competitive Moat of Purpose-Built AI33:01 — Agents as Customers: CLI, MCP, and AEO35:02 — Young Founders vs. Experienced Founders36:36 — The Idea Maze and Cloning Yourself With AI42:37 — The Magnifying Glass MomentApply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs
  • Y Combinator Startup Podcast

    How To Pick A Startup Idea

    2026/06/17 | 11 mins.
    Many founders get stuck trying to find the perfect startup idea before they commit. But the perfect idea doesn't exist in the abstract. The only way to find what works is to pick one, go deep, and get feedback from real customers.

    In this episode of Startup School, YC's Jon Xu breaks down how to choose what to build, "burn the other boats," and go deep enough to practically run your customer's business— and why that depth is what surfaces the better idea underneath.
  • Y Combinator Startup Podcast

    "The CEO Must Be the Chief AI Officer"

    2026/06/10 | 54 mins.
    Brex co-founder and CEO Pedro Franceschi believes most people still underestimate how much AI will change the way companies are built. AI isn't just another tool, it's a new foundation for building products, teams, and companies.In this episode of Lightcone, Pedro shares why he thinks we're only months into a platform shift as significant as the invention of electricity, how AI has changed the way he works, and why every founder should be "token maxing" to understand the limits of the technology firsthand.He explains why the CEO needs to be the chief AI officer, how Brex is rebuilding itself around AI, and why founders should rethink what's possible when intelligence is available on demand.
  • Y Combinator Startup Podcast

    How to Build an AI-Native Services Company

    2026/06/03 | 11 mins.
    Some of the biggest companies of the next decade won't be software businesses, they'll be services companies like insurance carriers, law firms, and tax practices rebuilt from scratch with AI doing most of the work. In this episode of Startup School, YC Visiting Partner Charlie Warren walks through the playbook for building AI native services companies, covering how to pick a market with the right traits, why variance kills these businesses faster than anything else, and the P&L math that’ll transform your business model.Chapters:00:00 — Intro to AI Services Companies01:01 — Picking the Right Market02:55 — Markets YC Likes Right Now03:43 — The Sam Altman Test04:35 — The Right Founding Team05:28 — Building the Product06:19 — Variance Is the Existential Problem07:08 — The Early Demand Trap07:53 — How to Price AI Services08:41 — The P&L Walkthrough09:33 — AI Operating Leverage10:27 — Don't Buy Your Way InApply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs
  • Y Combinator Startup Podcast

    How To Build Superintelligence Inside Your Company

    2026/05/27 | 46 mins.
    Building superintelligence inside a company isn't about adding AI as a feature. It's about making it the operating system the whole organization runs on. In this episode of the Lightcone, we sat down with YC's Pete Koomen to talk for the first time about how he led the effort to build YC's internal agent infrastructure from the ground up. We cover how giving agents unrestricted access to one database changed everything, the self-improving skill loops that get smarter overnight and why he thinks we've arrived at the personal computer moment for AI.Chapters:00:00 — Intro00:39 — YC's AI Stack02:15 — The Finance Team Problem That Started It All05:07 — SQL Access Changes Everything07:20 — One Database to Rule Them All09:14 — Jevons Paradox 10:07 — Denormalizing for Agents (G-Brain)12:15 — The Single-Player Era of Agents14:16 — 350 Tools and a Shared Registry16:24 — Skillify, DRY, and MECE Resolvers18:23 — The Self-Improving Dream Cycle20:26 — The Two-Sentence Pitch Skill23:06 — How Super Intelligence Compounds25:10 — Recording Everything as a Building Layer27:10 — The Shared Organizational Brain29:18 — Trust-Default Culture as a Requirement30:44 — Raising the Floor for New Employees32:35 — Horseless Carriages Essay Explained34:24 — Why Chat Is the Best Interface for Agents36:10 — Garry's List → G-Brain Rewrite38:50 — Just-in-Time Software40:49 — Centralizing vs. Decentralizing AI43:32 — The Personal AI RevolutionApply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs
More Technology podcasts
About Y Combinator Startup Podcast
We help founders make something people want. The Y Combinator Podcast is where builders talk about building. From the earliest days of an idea to scaling a company that changes the world, YC partners and founders share real stories, lessons, and tactics from the frontlines.
Podcast website

Listen to Y Combinator Startup Podcast, The Interface and many other podcasts from around the world with the radio.net app

Get the free radio.net app

  • Stations and podcasts to bookmark
  • Stream via Wi-Fi or Bluetooth
  • Supports Carplay & Android Auto
  • Many other app features
Y Combinator Startup Podcast: Podcasts in Family