The Immunology Podcast

Guest:

Dr. Alfred Singer is a Senior Investigator at the National Cancer Institute Center for Cancer Research. He discusses his pioneering work on thymus development and T cell differentiation, including how T cells are selected to become CD4 helper or CD8 cytotoxic cells through MHC-restricted signaling. He shares the evolution of key concepts in the field, such as the “kinetic signaling” model of lineage commitment, and offers insights into T cell receptor signaling, regulatory T cell development, and the complexities of immune cell fate decisions.

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The Immunology Science Round Up

CEACAM6 Enables Viral Entry – Bat alphacoronavirus enters human cells via CEACAM6, revealing potential for zoonotic transmission.

Cross-Dressing Drives T Cell Priming – mRNA vaccines activate CD8+ T cells through redundant dendritic cell pathways and cross-dressing mechanisms.

Unlocking NK Antitumor Responses – Removing tumor Tregs unleashes NK cell responses to control cancers, including MHC I–deficient tumors.

RUNX1 Controls Immune Aging – A single-cell immune aging clock identifies RUNX1 as a key regulator of T cell senescence and rejuvenation.

Image courtesy of Dr. Alfred Singer









































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In April 2026, we attended IMMUNOLOGY2026, the annual meeting of the American Association of Immunologists, in Boston. We spoke with delegates about their research and impressions of the meeting, including why they attended, the most memorable science they encountered, and their experiences in Boston.

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Guest:

This special episode was recorded in front of a live audience at IMMUNOLOGY2026 in Boston. Brenda and Jason sit down with Dr. Charles Sentman, Director of the Center for Synthetic Immunity at Dartmouth College, and Dr. Giulia Escobar, Director of Pre-Clinical Research at Massachusetts General Hospital, to explore new strategies aimed at overcoming the unique challenges of treating solid tumors. They focus on real-world challenges in CAR T and NK cell therapies, including barriers to treating solid tumors, manufacturing and accessibility hurdles, and emerging applications beyond oncology, such as autoimmunity and neurodegenerative disease.

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Stay up-to-date with the latest in human immunology news.

Download a free wallchart on the production of CAR T cells.

Image courtesy of [Drs. Charles Sentman and Giulia Escobar]









































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Guest:

In April 2026, we attended IMMUNOLOGY2026, the annual meeting of the American Association of Immunologists in Boston, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the last of five special episodes from the meeting. Jason and Brenda discuss highlights from sessions on advances in translational immunology, including immune-targeting strategies for autoimmune disease, as well as new insights into emerging technologies to map T cell receptor specificity.

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Make the most of your experience by downloading STEMCELL’s collection of tools to help you prepare for your next conference.









































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Guest:

In April 2026, we attended IMMUNOLOGY2026, the annual meeting of the American Association of Immunologists in Boston, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the fourth of five special episodes from the meeting. Jason and Brenda discuss highlights from talks about immunometabolic dysfunction in disease and neuroimmune interactions in inflammation and allergy.

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