Talk Python To Me

• #521: Red Teaming LLMs and GenAI with PyRIT

  English is now an API. Our apps read untrusted text; they follow instructions hidden in plain sight, and sometimes they turn that text into action. If you connect a model to tools or let it read documents from the wild, you have created a brand new attack surface. In this episode, we will make that concrete. We will talk about the attacks teams are seeing in 2025, the defenses that actually work, and how to test those defenses the same way we test code. Our guides are Tori Westerhoff and Roman Lutz from Microsoft. They help lead AI red teaming and build PyRIT, a Python framework the Microsoft AI Red Team uses to pressure test real products. By the end of this hour you will know where the biggest risks live, what you can ship this quarter to reduce them, and how PyRIT can turn security from a one time audit into an everyday engineering practice. Episode sponsors Sentry AI Monitoring, Code TALKPYTHON Agntcy Talk Python Courses Links from the show Tori Westerhoff: linkedin.com Roman Lutz: linkedin.com PyRIT: aka.ms/pyrit Microsoft AI Red Team page: learn.microsoft.com 2025 Top 10 Risk & Mitigations for LLMs and Gen AI Apps: genai.owasp.org AI Red Teaming Agent: learn.microsoft.com 3 takeaways from red teaming 100 generative AI products: microsoft.com MIT report: 95% of generative AI pilots at companies are failing: fortune.com A couple of "Little Bobby AI" cartoons Give me candy: talkpython.fm Tell me a joke: talkpython.fm Watch this episode on YouTube: youtube.com Episode #521 deep-dive: talkpython.fm/521 Episode transcripts: talkpython.fm Theme Song: Developer Rap Served in a Flask: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com Bluesky: @talkpython.fm Mastodon: talkpython X.com: talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: mkennedy Michael on X.com: mkennedy

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• #520: pyx - the other side of the uv coin (announcing pyx)

  A couple years ago, Charlie Marsh lit a fire under Python tooling with Ruff and then uv. Today he’s back with something on the other side of that coin: pyx. Pyx isn’t a PyPI replacement. Think server, not just index. It mirrors PyPI, plays fine with pip or uv, and aims to make installs fast and predictable by letting a smart client talk to a smart server. When the client and server understand each other, you get new fast paths, fewer edge cases, and the kind of reliability teams beg for. If Python packaging has felt like friction, this conversation is traction. Let’s get into it. Episode sponsors Six Feet Up Talk Python Courses Links from the show Charlie Marsh on Twitter: @charliermarsh Charlie Marsh on Mastodon: @charliermarsh Astral Homepage: astral.sh Pyx Project: astral.sh Introducing Pyx Blog Post: astral.sh uv Package on GitHub: github.com UV Star History Chart: star-history.com Watch this episode on YouTube: youtube.com Episode #520 deep-dive: talkpython.fm/520 Episode transcripts: talkpython.fm Theme Song: Developer Rap Served in a Flask: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com Bluesky: @talkpython.fm Mastodon: talkpython X.com: talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: mkennedy Michael on X.com: mkennedy

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• #519: Data Science Cloud Lessons at Scale

  Today on Talk Python: What really happens when your data work outgrows your laptop. Matthew Rocklin, creator of Dask and cofounder of Coiled, and Nat Tabris a staff software engineer at Coiled join me to unpack the messy truth of cloud-scale Python. During the episode we actually spin up a 1,000 core cluster from a notebook, twice! We also discuss picking between pandas and Polars, when GPUs help, and how to avoid surprise bills. Real lessons, real tradeoffs, shared by people who have built this stuff. Stick around. Episode sponsors Seer: AI Debugging, Code TALKPYTHON Talk Python Courses Links from the show Matthew Rocklin: @mrocklin Nat Tabris: tabris.us Dask: dask.org Coiled: coiled.io Watch this episode on YouTube: youtube.com Episode #519 deep-dive: talkpython.fm/519 Episode transcripts: talkpython.fm Theme Song: Developer Rap Served in a Flask: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com Bluesky: @talkpython.fm Mastodon: talkpython X.com: talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: mkennedy Michael on X.com: mkennedy

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• #518: Celebrating Django's 20th Birthday With Its Creators

  Twenty years after a scrappy newsroom team hacked together a framework to ship stories fast, Django remains the Python web framework that ships real apps, responsibly. In this anniversary roundtable with its creators and long-time stewards: Simon Willison, Adrian Holovaty, Will Vincent, Jeff Triplett, and Thibaud Colas, we trace the path from the Lawrence Journal-World to 1.0, DjangoCon, and the DSF; unpack how a BSD license and a culture of docs, tests, and mentorship grew a global community; and revisit lessons from deployments like Instagram. We talk modern Django too: ASGI and async, HTMX-friendly patterns, building APIs with DRF and Django Ninja, and how Django pairs with React and serverless without losing its batteries-included soul. You’ll hear about Django Girls, Djangonauts, and the Django Fellowship that keep momentum going, plus where Django fits in today’s AI stacks. Finally, we look ahead at the next decade of speed, security, and sustainability. Episode sponsors Seer: AI Debugging, Code TALKPYTHON Sentry AI Monitoring, Code TALKPYTHON Talk Python Courses Links from the show Guests Simon Willison: simonwillison.net Adrian Holovaty: holovaty.com Will Vincent: wsvincent.com Jeff Triplett: jefftriplett.com Thibaud Colas: thib.me Show Links Django's 20th Birthday Reflections (Simon Willison): simonwillison.net Happy 20th Birthday, Django! (Django Weblog): djangoproject.com Django 2024 Annual Impact Report: djangoproject.com Welcome Our New Fellow: Jacob Tyler Walls: djangoproject.com Soundslice Music Learning Platform: soundslice.com Djangonaut Space Mentorship for Django Contributors: djangonaut.space Wagtail CMS for Django: wagtail.org Django REST Framework: django-rest-framework.org Django Ninja API Framework for Django: django-ninja.dev Lawrence Journal-World: ljworld.com Watch this episode on YouTube: youtube.com Episode #518 deep-dive: talkpython.fm/518 Episode transcripts: talkpython.fm Theme Song: Developer Rap Served in a Flask: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com Bluesky: @talkpython.fm Mastodon: talkpython X.com: talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: mkennedy Michael on X.com: mkennedy

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• #517: Agentic Al Programming with Python

  Agentic AI programming is what happens when coding assistants stop acting like autocomplete and start collaborating on real work. In this episode, we cut through the hype and incentives to define “agentic,” then get hands-on with how tools like Cursor, Claude Code, and LangChain actually behave inside an established codebase. Our guest, Matt Makai, now VP of Developer Relations at DigitalOcean, creator of Full Stack Python and Plushcap, shares hard-won tactics. We unpack what breaks, from brittle “generate a bunch of tests” requests to agents amplifying technical debt and uneven design patterns. Plus, we also discuss a sane git workflow for AI-sized diffs. You’ll hear practical Claude tips, why developers write more bugs when typing less, and where open source agents are headed. Hint: The destination is humans as editors of systems, not just typists of code. Episode sponsors Posit Talk Python Courses Links from the show Matt Makai: linkedin.com Plushcap Developer Content Analytics: plushcap.com DigitalOcean Gradient AI Platform: digitalocean.com DigitalOcean YouTube Channel: youtube.com Why Generative AI Coding Tools and Agents Do Not Work for Me: blog.miguelgrinberg.com AI Changes Everything: lucumr.pocoo.org Claude Code - 47 Pro Tips in 9 Minutes: youtube.com Cursor AI Code Editor: cursor.com JetBrains Junie: jetbrains.com Claude Code by Anthropic: anthropic.com Full Stack Python: fullstackpython.com Watch this episode on YouTube: youtube.com Episode #517 deep-dive: talkpython.fm/517 Episode transcripts: talkpython.fm Theme Song: Developer Rap Served in a Flask: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com Bluesky: @talkpython.fm Mastodon: talkpython X.com: talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: mkennedy Michael on X.com: mkennedy

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