JHLT: The Podcast

In case you missed it, JHLT: The Podcast is re-releasing a past audience favorite for your listening pleasure. This month, we revisit a conversation regarding a study from the April 2025 issue of JHLT about the efficacy and safety of sotatercept in patients with PAH.
This conversation with Ioana Preston, MD, of the Tufts University School of Medicine in Boston, explores:
What makes sotatercept unique as the first "biologic" in the treatment of PAH
Hypotheses about the mechanism of action in sotatercept
Sotatercept's interaction with mPAP and what it indicates about the drug's action on the pulmonary vasculature
For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.
Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

JHLT: The Podcast returns for July with a paper entitled "Comparing DSA-negative and DSA-positive antibody-mediated rejection in heart transplants: Results from the Trifecta-Heart study," available online now and in the July print issue of JHLT.
Today's guests are first author Katelynn S. Madill-Thomsen, PhD and senior author Philip F. Halloran, MD, PhD, both from the Alberta Transplant Applied Genomics Center in Canada.
In the episode, the authors and editors discuss:
Striking similarities—and key differences—in the DSA-negative and DSA-positive groups
Changes to clinical practice based on the findings, including innovations from the kidney transplant community
Future studies, including tools and therapies that could be explored for improved clinical outcomes
For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.
Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

For the first time, JHLT: The Podcast welcomes a patient onto the podcast. The Digital Media Editors are pleased to welcome heart transplant recipient and patient advocate Payton Herres for a discussion about her recent perspective piece in JHLT.
In this compelling, moving discussion, Payton shares:
Her treatment story—from her congenital diagnoses to her life-changing transplant—and her donor's story
The difference between coverage and access—and how FDA labeling affected her access to an important component of her care
What she wishes clinicians understood about long-term care of transplant patients
For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.
Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On JHLT: The Podcast, we kick off June with a paper entitled "Serial assessment of modified Society for Cardiovascular Angiography and Interventions SHOCK classification in post-cardiotomy patients," which is available online now and in the June issue of JHLT.
Today's guests are first author Ufuk Baldan, MD and senior author Patrick Klein, MD, PhD, both of the Amsterdam University Medical Center in the Netherlands.
We discuss:
The heterogeneous nature of post-cardiotomy shock and challenges to treat
Should serial assessments become standardized post-cardiac surgery?
Does SCAI staging overestimate risk—and how do we interpret the stages we observe immediately post-op?
What's next for this line of research?
For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.
Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

On this special episode of JHLT: The Podcast, the Digital Media Editors take a look back at the exciting science that was on display at ISHLT2026, the ISHLT 46th Annual Meeting & Scientific Sessions.
Topics include:
Artificial intelligence and machine learning in transplantation, especially in assessing donor lungs and EVLP
Cardiogenic Shock science at ISHLT2026, including a well-attended, all-new Academy
The re-launch of the ISHLT International Thoracic Organ Transplant Registry, and the recent report in JHLT
For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.
Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.