BIOACTIVE

Riley D. Kirk, Ph.D.
BIOACTIVE
Latest episode

81 episodes

  • BIOACTIVE

    Beyond Caffeine: The Hidden Chemistry of Coffee with Dr. Steven Helschien (Dr. Coffee)

    2026/03/06 | 1h 9 mins.
    There are all sorts of misconceptions about coffee — that it dehydrates you, that it’s bad for your heart, or that caffeine is the only thing happening in the cup.

    Dr. Riley Kirk welcomes coffee scientist Dr. Steven Helschien, widely known as “Dr. Coffee,” for a fascinating conversation exploring the chemistry, health effects, and cultural significance of one of the world’s most widely consumed psychoactive plants: coffee. With a background in chemistry and extensive experience in coffee education and research, Dr. Helschien breaks down the complex science behind coffee in a way that is both practical and accessible.

    They discuss coffee as a psychoactive plant medicine, examining not only caffeine but also the wide range of entourage compounds that influence its physiological and cognitive effects.

    Dr. Helschien and Dr. Kirk explore coffee’s relationship with inflammation, liver health, and cardiovascular markers, unpacking what current research suggests about coffee consumption and long-term wellness. They also explore the importance of coffee quality, including concerns about mold contamination, sourcing practices, and what consumers should look for when choosing high-quality beans. The conversation touches on brewing techniques and the science of extraction, the chemistry behind decaffeination methods, and why caffeine affects the body the way it does.
    The episode also expands into broader discussions about coffee as plant medicine, the cultural role of caffeine, and the fine line between daily ritual and dependence.
    Dr. Helschien shares insights into mold-free coffee sourcing, considerations around caffeine and breastfeeding, and practical strategies like caffeine cycling to maintain sensitivity to its effects.

    This is a conversation for anyone who loves coffee but wants to understand what’s really happening in the cup. Whether you're curious about caffeine’s effects, confused by common coffee myths, exploring brewing methods, or simply trying to get more out of your daily ritual, this episode offers science-backed insight in an accessible way. From the chemistry of flavor and roasting to the physiology of caffeine and the cultural habits surrounding coffee, Dr. Helschien helps demystify one of the world’s most widely consumed beverages.

    Episode Chapters:
    01:02 Meet Dr Coffee
    02:08 Psychoactive Plant
    03:04 Entourage Compounds
    06:04 Inflammation And Liver
    08:19 Quality And Mold
    10:13 Brain Heart Plaque
    23:43 Brewing And Decaf
    35:43 Decaf Methods Explained
    36:49 Why Caffeine Works
    38:36 Coffee as Plant Medicine
    39:39 Coffee Addiction and Culture
    43:12 Mold Free Coffee Buying
    45:49 Breastfeeding and Caffeine
    47:20 Caffeine Cycling Hack
    59:15 Community Q&A and Wrap Up

    Get Free Coffee Science Resource from Dr. Helschien:
    [email protected]

    Connect with Dr. Helschien:
    LinkedIn - Dr. Steven Helschien

    Want Exclusive Content and Ad-Free Episodes?
    Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.
    www.Patreon.com/Cannabichem

    🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, pharmacology, and plant-based medicine!

    Sign Up for Emails
    www.AppliedPharmacognosy.org

    Keep Up with Dr. Riley Kirk
    https://www.bioactivepodcast.com/
    https://www.youtube.com/@cannabichem
    https://instagram.com/cannabichem
    https://www.appliedpharmacognosy.org/
    Learn more about your ad choices. Visit megaphone.fm/adchoices
  • BIOACTIVE

    How Fast-Acting Products Actually Work with Harold Han, PhD

    2026/02/20 | 57 mins.
    Dr. Riley Kirk welcomes Dr. Harold Han, Chief Science Officer and Co-Founder of Vertosa to explore the fascinating world of the science powering modern cannabis beverages and infused products. Known in
    the industry as “The Happy Chemist,” Dr. Han explains how emulsion technology solves the classic oil-and-water problem that makes cannabinoids difficult to incorporate into drinks. The conversation breaks down how water-compatible cannabinoids are created, why droplet size and consistency matter for potency and onset, and how stability challenges differ between beverages and gummies.

    They explore oxidation rates of major cannabinoids, packaging risks like
    “scalping” from can liners, and new patented approaches to preserving potencyin infused drinks.

    They also examine the full beverage development pipeline, from cannabinoids and infusion technology to formulation, manufacturing,
    testing, and distribution, highlighting the many points where potency and
    quality can be affected. Dr. Han clarifies the difference between nano and
    micro emulsions, why most commercial cannabis drinks use nano systems, and how natural emulsifiers influence formulation choices. The discussion further explores how the human body processes emulsified cannabinoids, why food (especially fat) changes edible effects, and how fast-acting beverages work at a physiological level. They discuss new human research initiatives, patient applications such as consistent dosing without sugar or smoke, and how standardized emulsions could transform both clinical research and at-home use.

    Looking ahead, Dr. Han shares insights on full-plant formulations, the future of cannabis as a precise delivery system for medicine, and the role of science-driven innovation in making cannabinoids more accessible, consistent, and scalable across recreational, wellness, and medical markets.

    Chapters

    00:00 Welcome + Meet Dr. Harold Hahn (“Happy Chemist”) & What Vert Does

    00:52 From Cannabis Stigma to Conscious Living: Harold’s Personal Journey

    02:18 The Oil-and-Water Problem: Emulsifiers Explained for Cannabis Drinks

    04:13 Vert’s Water-Compatible Cannabinoids: Droplet Size, Consistency & Effects

    09:48 Stability Deep Dive: Physical Separation, Oxidation Rates & Gummies vs Beverages

    16:05 Packaging Pitfalls: Can Liners, “Scalping,” FTIR Testing & a New Patent Fix

    22:49 Beverage R&D Checklist: The 7-Step Supply Chain + Taste/Mouthfeel Priorities

    27:16 Flavor Wars: Tasteless THC vs “Tastes Like the Plant”

    28:37 Nano vs Micro Emulsions Explained (It’s Not Just Size)

    31:40 Why Most Cannabis Drinks Use Nano: Natural Emulsifiers
    & Custom Control

    34:38 Fast-Acting vs Slow-Acting: What Your Gut Does With
    Emulsions

    37:41 Food Effects + The New UCSF Cannabis Beverage PK Lab

    40:32 Patient Benefits: Consistent Dosing, No Sugar, Full-Plant Medicine

    44:23 Research, DIY Possibilities & Big-Picture Wrap-Up

     

    Connect with Dr. Harold Han

    LinkedIn: Harold Han Ph.D. (The Happy Chemist)

    Company: Vertosa — https://vertosa.com/

     

    Want Exclusive Content and Ad-Free Episodes?

    Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.
    www.Patreon.com/Cannabichem

    🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, pharmacology, and industry innovation!

     

    Sign Up for Emails

    www.AppliedPharmacognosy.org

     

    Keep Up with Dr. Riley Kirk

    https://www.bioactivepodcast.com/
    https://www.youtube.com/@cannabichem
    https://instagram.com/cannabichem
    https://www.appliedpharmacognosy.org/
    Learn more about your ad choices. Visit megaphone.fm/adchoices
  • BIOACTIVE

    Schedule 3, Hemp Bans, and Cannabis Law with Thomas Howard

    2026/02/06 | 1h 4 mins.
    In this episode of the Bioactive Podcast, Dr. Riley Kirk welcomes cannabis attorney and legalization advocate Tom Howard to unpack the complexities of cannabis law and regulation in the United States. Drawing on more than 15 years of experience, Tom shares how he helps clients navigate licensing and application processes for dispensaries and cannabis businesses across multiple states. Together, they explore how state-by-state regulatory systems function, the challenges of securing permits, and the financial barriers facing cannabis entrepreneurs, particularly social equity applicants.

    The conversation also examines the federal effort to move cannabis from Schedule I to Schedule III, discussing what rescheduling could mean for taxation, scientific research, and cannabis operations nationwide.
    Additional topics include the recent hemp ban and its impact on THCA products, seed sales, and interstate commerce, ongoing banking challenges in the cannabis industry, advocacy organizations pushing for reform, and legal strategies for remaining compliant in a shifting regulatory environment. Tom also offers insight into his work with Cannabis Legalization News before the episode closes with a forward-looking discussion on the future of legalization and cannabis policy.

    Chapters:

    00:00 Introduction to the Bioactive Podcast

    00:36 Tom Howard's Journey in Cannabis Law

    01:17 Navigating State Regulations and Applications

    03:46 Challenges and Legal Complexities

    06:24 Financial Hurdles in the Cannabis Industry

    15:13 The Impact of Federal Law and Rescheduling

    30:27 Advocacy and Future of Cannabis Legislation

    34:17 THCA and Synthetic Cannabinoids Ban

    34:41 Congressional Actions and Implications

    37:14 Banking Challenges for Cannabis Businesses

    38:53 Project 2025 and Political Climate

    40:22 Hemp Industry Loopholes and Regulations

    51:33 Cannabis Legalization News and Podcast

    55:17 Future of Cannabis Legislation

     

    Watch Cannabis Legalization News
    www.youtube.com/@CannabisLegalizationNews

    Learn more about Thomas Howard
    https://cannabisindustrylawyer.com

    Visit Collateral Base
    https://collateralbase.com

    Connect with Tom

    www.linkedin.com/in/thomas-howard-attorney

     

    Want Exclusive Content and ad-free episodes?

    Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one. www.Patreon.com/Cannabichem

    Be sure to like, subscribe, and turn on notifications for more expert conversations on cannabis science, federal policy updates, and industry trends.

    Sign Up for Emails! 

    www.AppliedPharmacognosy.org

      

    Keep up with Dr. Riley Kirk:

    https://www.bioactivepodcast.com/

    https://www.youtube.com/@cannabichem

    https://instagram.com/cannabichem

    https://www.appliedpharmacognosy.org/
    Learn more about your ad choices. Visit megaphone.fm/adchoices
  • BIOACTIVE

    The Untapped World of Acidic Cannabinoids with Dr. Bid

    2026/01/23 | 1h 12 mins.
    In this episode of the Bioactive Podcast, Dr. Hemant Bid joins Dr. Riley Kirk discussing the often-overlooked world of acidic cannabinoids aka Raw or Unactivated cannabinoids, such as CBGA, THCA, and CBDA. He shares his extensive background in cannabis research and education, emphasizing the therapeutic potential of these compounds, which are non-psychoactive and interact with various non-cannabinoid targets in the body. The conversation also delves into extraction techniques for preserving these cannabinoids, their role in plant defense, and the future of research in this area. Dr. Bid highlights the importance of personalized medicine and the need for more education and understanding in the field of medical cannabis.

    Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠
    🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more!

    Follow Dr. Bid on LinkedIn
    https://www.linkedin.com/in/hemant-kumar-bid-bs-ms-phd-ms-pharmacology-60aabb15/
    Sign Up for Emails! 
    ⁠www.AppliedPharmacognosy.org⁠ 
    Keep up with Dr. Riley Kirk:
    ⁠⁠⁠⁠⁠https://www.bioactivepodcast.com/⁠⁠⁠⁠⁠
    ⁠⁠⁠⁠⁠https://www.youtube.com/@cannabichem⁠⁠⁠⁠⁠
    ⁠⁠⁠⁠⁠https://instagram.com/cannabichem⁠⁠⁠⁠⁠
    ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠⁠⁠
    Learn more about your ad choices. Visit megaphone.fm/adchoices
  • BIOACTIVE

    Cannabis Question and Answer Sesh!

    2025/12/12 | 53 mins.
    In this episode of the Bioactive Podcast, Dr. Riley Kirk shares a 2025 year-in-review and announces exciting news about teaching a cannabis chemistry and pharmacology course at Vermont State University next Spring. Riley then dives into a Q&A packed with highly requested cannabis education topics, answering real listener questions about nanoemulsification safety, whether CBN truly helps with sleep, and the pros and cons of dabbing concentrates.

    She also breaks down how to talk to family about cannabis use, the science behind THC:CBD ratios, why “indica vs. sativa” is largely a myth, and how different strain chemistries influence effects. Riley explains the difference between live resin vs. live rosin vape cartridges, how nano cannabis products work in the body, and whether already-vaped cannabis is still edible or effective.

    If you are curious about cannabis science, consumption methods, harm reduction, or understanding how cannabinoids and terpenes really work, this episode is packed with practical insights. Riley closes with a warm holiday message and a look ahead at what’s coming in 2026.

    Topics covered: cannabis chemistry, nano THC safety, CBN for sleep, dabbing benefits, THC/CBD ratios, terpene science, talking about cannabis with family, live resin vs. live rosin, cannabis education, pharmacology, cannabis myths, and more.

    Chapters

    00:00 Reflecting on the Year and Future Plans

    02:47 Q&A: Exploring Cannabis and Pharmacology

    05:56 Creating Custom Cannabis Experiences

    08:27 Understanding CBN and Its Effects

    10:37 Dabbing: Benefits and Drawbacks

    26:37 Understanding Dabs: Pros and Cons

    29:03 Coming Out of the Green Closet

    32:36 Engaging with the Cannabis Science Community

    35:11 Balancing THC with CBD

    38:47 THC and Seizure Treatment

    41:16 Debunking the Indica vs. Sativa Myth

    46:12 Vape Cartridges: Live Resin vs. Live Rosin

    52:03 Using Vaped Cannabis for Edibles

    VTSU Course Information:

    For non-matriculated students (those not fully enrolled in VTSU), form:

    https://connect.vermontstate.edu/register/NonMatricStudents

    Section and Number: HUM-2710-S01, Course 1 title: Cannabis as Medicine

    Join the Bioactive Patreon community for as little as $1/month to ask guests your burning questions, access exclusive content, and connect with Dr. Kirk one-on-one.⁠⁠⁠⁠⁠⁠⁠⁠⁠ www.Patreon.com/Cannabichem⁠⁠⁠⁠⁠⁠⁠⁠⁠

    🔔 Don’t forget to like, subscribe, and hit the notification bell for more expert insights into cannabis science, plant biology, and more!

    Sign Up for Emails! 

    www.AppliedPharmacognosy.org 

    Keep up with Dr. Riley Kirk:

    ⁠⁠⁠⁠https://www.bioactivepodcast.com/⁠⁠⁠⁠

    ⁠⁠⁠⁠https://www.youtube.com/@cannabichem⁠⁠⁠⁠

    ⁠⁠⁠⁠https://instagram.com/cannabichem⁠⁠⁠⁠

    ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.appliedpharmacognosy.org/⁠⁠⁠⁠

    Learn more about your ad choices. Visit megaphone.fm/adchoices

More Science podcasts

About BIOACTIVE

Dr. Riley Kirk is a cannabis research scientist and educator. She obtained her Ph.D. in pharmaceutical sciences, specializing in natural product chemistry, studying the traditional and contemporary uses of hundreds of medicinal plants. She is currently an assistant associate professor at the University of Rhode Island, has worked as an immunology scientist in the biotech industry, and works in the cannabis industry studying the chemical complexity of cannabis smoke. Riley is also the co-founder of the cannabis research and education non-profit organization called the Network of Applied Pharmacognosy (NAP). Through NAP and on her podcast, Riley uses science as advocacy to research and communicate findings that highlight the unique power of natural products. The goal of Riley’s work is to unite people in the Cannabis industry, academia, and consumers to further the reach of Cannabis education and reduce harm. Riley is passionate about making Cannabis science accessible through social media channels and alternative media which lead to Bioactive; an educational podcast which disseminates the chemistry and pharmacology of natural products. On this bi-weekly podcast, she covers current news and research surrounding cannabis, psychedelics, toxins, pharmaceuticals & other bioactive substances. Listen for special guests highlighting community stories.
Podcast website

Listen to BIOACTIVE, The Infinite Monkey Cage and many other podcasts from around the world with the radio.net app

Get the free radio.net app

  • Stations and podcasts to bookmark
  • Stream via Wi-Fi or Bluetooth
  • Supports Carplay & Android Auto
  • Many other app features
Social
v8.7.2 | © 2007-2026 radio.de GmbH
Generated: 3/13/2026 - 12:40:47 PM